Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice
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Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new- world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-associated diseases, have not been available. Recently the development of severely immunodeficient mouse strains enabled production of humanized mice in which human immune system components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author’s group addressing reproduction of EBV infection and pathogenesis in humanized mice.
Abstract
Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new- world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-associated diseases, have not been available. Recently the development of severely immunodeficient mouse strains enabled production of humanized mice in which human immune system components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author’s group addressing reproduction of EBV infection and pathogenesis in humanized mice.
참고문헌 (38)
- Longnecker, R. M., "Fields Virology", pp.1898~1959 (2013), Lippincott Williams and Wlikins
- Hislop, A. D., "Cellular responses to viral infection in humans: lessons from Epstein-Barr virus", Annu. Rev. Immunol, 25, pp.587~617 (2007)
- Shope, T., "Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus", Proc. Natl. Acad. Sci. USA, 70, pp.2487~2491 (1973)
- Epstein, M. A., "Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). III. Serological and biochemical findings in an animal with reticuloproliferative disease", Int. J. Cancer, 15, pp.17~22 (1975)
- Johannessen, I., "In vivo models for Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disease (BLPD)", Rev. Med. Virol, 9, pp.263~277 (1999)
- Takashima, K., "A new animal model for primary and persistent Epstein-Barr virus infection: human EBV-infected rabbit characteristics determined using sequential imaging and pathological analysis", J. Med. Virol, 80, pp.455~466 (2008)
- Ito, M., "NOD", SCID, Blood, pp.2002, 100[DOI]
- Traggiai, E., "Development of a human adaptive immune system in cord blood cell-transplanted mice", Science, 304, pp.104~107 (2004)
- Shultz, L. D., "Human lymphoid and myeloid cell development in NOD", LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells, 2005, pp.174, 6477~6489
- Melkus, M. W., "Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1", Nat. Med, 12, pp.1316~1322 (2006)
- Fujiwara, S., "Humanized mouse models of Epstein-Barr virus infection and associated diseases", Pathogens, 2, pp.153~176 (2013)
- Akkina, R, "New generation humanized mice for virus research: comparative aspects and future prospects", Virology, 435, pp.14~28 (2013)
- Hiramatsu, H., "Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD", SCID, Blood, pp.2003, 102[DOI]
- Watanabe, S., "Hematopoietic stem cell-engrafted NOD", SCID, Blood, pp.2007, 109[DOI]
- Watanabe, S., "Humanized NOD", SCID, J. Virol, pp.2007, 81[DOI]
- Yajima, M., "A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses", J. Infect. Dis, 198, pp.673~682 (2008)
- Strowig, T., "Priming of protective T cell responses against virus-induced tumors in mice with human immune system components", J. Exp. Med, 206, pp.1423~1434 (2009)
- Ma, S. D., "A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas", J. Virol, 85, pp.165~177 (2011)
- Ma, S. D., "An Epstein-Barr Virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model", J. Virol, 86, pp.7976~7987 (2012)
- White, R. E., "EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors", J. Clin. Invest, 122, pp.1487~1502 (2012)
- Wahl, A., "A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo", J. Virol, 87, pp.5437~5446 (2013)
- Cocco, M., "CD34+ cord blood cell-transplanted Rag2−", − gamma(c)−, Am. J. Pathol, pp.2008, 173[DOI]
- McInnes, I. B., "The pathogenesis of rheumatoid arthritis", N. Engl. J. Med, 365, pp.2205~2219 (2011)
- Niller, H. H., "Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease", Adv. Exp. Med. Biol, 711, pp.82~102 (2011)
- Toussirot, E, "Pathophysiological links between rheumatoid arthritis and the Epstein-Barr virus: an update", Joint Bone Spine, 74, pp.418~426 (2007)
- Takei, M., "Detection of Epstein-Barr virus-encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients", Int. Immunol, 9, pp.739~743 (1997)
- Kuwana, Y., "Epstein-Barr virus induces erosive arthritis in humanized mice", PLoS One, 6, pp.e26630~ (2011)
- Watanabe, Y., "The analysis of the functions of human B and T cells in humanized NOD", shi- scid, Int. Immunol, pp.2009, 21[DOI]
- Yajima, M., "T cell-mediated control of Epstein-Barr virus infection in humanized mice", J. Infect. Dis, 200, pp.1611~1615 (2009)
- Kikuta, H., "Fatal Epstein-Barr virus-associated hemophagocytic syndrome", Blood, 82, pp.3259~3264 (1993)
- Kawaguchi, H., "Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome", J. Clin. Invest, 92, pp.1444~1450 (1993)
- Kawa-Ha, K., "CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA", J. Clin. Invest, 84, pp.51~55 (1989)
- Jones, J. F., "T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections", N. Engl. J. Med, 318, pp.733~741 (1988)
- Kikuta, H., "Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease", Nature, 333, pp.455~457 (1988)
- Ishihara, S., "Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection", Jpn. J. Cancer Res, 80, pp.99~101 (1989)
- Imadome, K., "Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells", PLoS Pathog, 7, pp.e1002326~ (2011)
- Sato, K., "A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice", Blood, 117, pp.5663~5673 (2011)
- Shultz, L. D., "Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD", SCID, Proc. Natl. Acad. Sci. USA, pp.2010, 107[DOI]
