Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
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Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.
Abstract
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.
참고문헌 (28)
- Cohen JI, "Epstein-Barr virus infection", N Engl J Med, 343, pp.481~ (2000)
- Pittaluga S, "Hematopathology", pp.547~607 (2016), Elsevier Heealth Science
- Swerdlow SH, "The 2016 revision of the World Health Organization classification of lymphoid neoplasms", Blood, 127, pp.2375~2390 (2016)
- Chaganti S, "Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence", Blood, 113, pp.6372~6381 (2009)
- Vouloumanou EK, "Current diagnosis and management of infectious mononucleosis", Curr Opin Hematol, 19, pp.14~20 (2012)
- Fletcher C, "Diagnostic histopathology of tumors", pp.2007, Churchill Livingstone
- Lekstrom-Himes JA, "Periodic illness associated with Epstein-Barr virus infection", Clin Infect Dis, 22, pp.22~27 (1996)
- 조은윤, "The Spectrum of Epstein-Barr Virus-Associated Lymphoproliferative Disease in Korea: Incidence of Disease Entities by Age Groups", Journal of Korean Medical Science, 23(2), pp.185~192 (2008), 대한의학회
- Cohen JI, "Characterization and treatment of chronic active Epstein-Barr virus disease : a 28-year experience in the United States", Blood, 117, pp.5835~5849 (2011)
- Swerdlow SH, "WHO classification of tumors of hematopoietic and lymphoid tissues" (2008), IARC Press
- Nicolae A, "EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment", Blood, 126, pp.863~872 (2015)
- Dojcinov SD, "EBV positive mucocutaneous ulcer--a study of 26 cases associated with various sources of immunosuppression", Am J Surg Pathol, 34, pp.405~417 (2010)
- Hongyo T, "Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma", Cancer Res, 58, pp.1105~1107 (1998)
- Katzenstein AL, "Lymphomatoid granulomatosis : a clinicopathologic study of 152 cases", Cancer, 43, pp.360~373 (1979)
- Song JY, "Lymphomatoid granulomatosis : a single institute experience : pathologic findings and clinical correlations", Am J Surg Pathol, 39, pp.141~156 (2015)
- Kimura H, "EBV-associated T", NK-cell lymphoproliferative diseases in nonimmunocompromised hosts : prospective analysis of 108 cases, 2012, pp.119, 673~686
- Toga A, "Clinical significance of cloned expansion and CD5 down-regulation in Epstein-Barr Virus(EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis", J Infect Dis, 201, pp.1923~1932 (2010)
- Ohshima K, "Proposed categorization of pathological states of EBV-associated T", natural killer-cell lymphoproliferative disorder(LPD)in children and young adults : overlap with chronic active EBV infection and infantile fulminant EBV TLPD, 2008, pp.58, 209~217
- Ko YH, "EBV-associated T and NK cell lymphoproliferative disorders: consensus report of the 4th Asian Hematopathology Workshop", J Hematopathol, 5, pp.319~324 (2012)
- Cohen JI, "Epstein-Barr virusassociated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008", Ann Oncol, 20, pp.1472~1482 (2009)
- Park S, "Epstein-Barr virus-associated T", natural killer-cell lymphoproliferative disorders, 2014, pp.41, 29~39
- Miyake T, "Survival rates and prognostic factors of Epstein-Barr virus-associated hydroa vacciniforme and hypersensitivity to mosquito bites", BrJ Dermatol, 172, pp.56~63 (2015)
- Cho KH, "Epstein-Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions", Clin Exp Dermatol, 26, pp.242~247 (2001)
- Quintanilla-MartinezL, "FulminantEBV(+)T-cell lymphoproliferative disorder following acute", chronic EBV infection: a distinct clinicopathologic syndrome, 2000, pp.96, 443~451
- Hong M, "Nasal-type NK", T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior, 2016, pp.29, 430~443
- Chan JK, "Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm", Blood, 89, pp.4501~ (1997)
- Kato S, "T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): a clinicopathologic study of 39 cases", Am J Surg Pathol, 39, pp.462~471 (2015)
- JeonYK, "Epstein-Barr virus-positive nodal T", NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features, 2015, pp.46, 981~990