3-NP에 의해 유발된 신경교세포의 산화적 손상에 대한 南星의 보호효과
The Neuroprotective Effect of Rhizoma Arisaematis on 3-NP-induced Oxidative Injury of C6 Glial Cells
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Abstract
Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced cytotoxicity in rat C6 glial cells. Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability, and morphological change, which was associated with elevation of ROS level, increase in Bax/Bcl2 ratio and HIF-a protein expression.Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax, and increased the activity of Bcl2 in C6 glial cells.Conclusions : RA markedly protects C6 glial cells from 3-NP-induced oxidative injury.
참고문헌 (23)
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