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알레르기비염 발생의 위험 인자와 현증 알레르기비염의 폐기능 및 기관지과민성

Risk factors, lung function and bronchial hyperresponsiveness in current dust mite-induced allergic rhinitis

박지원|이소연|최연정|홍수종|박강서|정은초
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2016.01|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제4권 제1호|pp. 49-54|DOI http://dx.doi.org/10.4168/aard.2016.4.1.49

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키워드

ChildAllergic rhinitisRisk factorSpirometryBronchial hyperreactivity
주제분류소아과학

초록

Purpose: We analyzed the pulmonary function and risk factors of allergic rhinitis (AR) in dust mite-sensitized children with current AR and no history of asthma. Methods: In this cross-sectional study, demographic and disease-related information was obtained from 1,792 Korean children aged 9–12 years using a questionnaire, skin-prick testing, spirometric analysis, and methacholine challenge testing. Results: A total of 672 children were analyzed. The control group consisted of 583 children without any allergic diseases who were not sensitized to 16 common allergens. The group with current AR and dust mite sensitization consisted of 89 children. Binary logistic regression analysis showed that helminth infection (adjusted odds ratio [aOR], 2.88; 95% confidence interval [CI], 1.23–6.77) and antibiotic use during infancy (aOR, 1.89; 95% CI, 1.10–3.25) were the risk factors. Pet ownership (aOR, 0.32; 95% CI, 0.15–0.69) and older siblings (aOR, 0.58; 95% CI, 0.35–0.96) were protective factors. Spirometry results did not differ between the control and dust mite-induced AR groups. None of the children showed a bronchodilator response. However, 8.5%, 7.1%, and 2.1% of the control-group children and 28.7%, 23.0%, and 8.0% of the dust mite-induced AR-group children showed methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second) values of ≤25 mg/mL, ≤16 mg/mL, and ≤8 mg/mL, respectively (P<0.01). Conclusion: The prevalence of current dust mite-induced AR may be reduced by controlling environmental factors. Even though the spirometry results seemed to be normal, bronchial hyperresponsiveness occurred more frequently in children with dust mite-induced AR than in normal children.

Abstract

Purpose: We analyzed the pulmonary function and risk factors of allergic rhinitis (AR) in dust mite-sensitized children with current AR and no history of asthma. Methods: In this cross-sectional study, demographic and disease-related information was obtained from 1,792 Korean children aged 9–12 years using a questionnaire, skin-prick testing, spirometric analysis, and methacholine challenge testing. Results: A total of 672 children were analyzed. The control group consisted of 583 children without any allergic diseases who were not sensitized to 16 common allergens. The group with current AR and dust mite sensitization consisted of 89 children. Binary logistic regression analysis showed that helminth infection (adjusted odds ratio [aOR], 2.88; 95% confidence interval [CI], 1.23–6.77) and antibiotic use during infancy (aOR, 1.89; 95% CI, 1.10–3.25) were the risk factors. Pet ownership (aOR, 0.32; 95% CI, 0.15–0.69) and older siblings (aOR, 0.58; 95% CI, 0.35–0.96) were protective factors. Spirometry results did not differ between the control and dust mite-induced AR groups. None of the children showed a bronchodilator response. However, 8.5%, 7.1%, and 2.1% of the control-group children and 28.7%, 23.0%, and 8.0% of the dust mite-induced AR-group children showed methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second) values of ≤25 mg/mL, ≤16 mg/mL, and ≤8 mg/mL, respectively (P<0.01). Conclusion: The prevalence of current dust mite-induced AR may be reduced by controlling environmental factors. Even though the spirometry results seemed to be normal, bronchial hyperresponsiveness occurred more frequently in children with dust mite-induced AR than in normal children.

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한국 초·중·고등학생 알레르기비염의 전국 유병률과 위험 인자에 대한 분석이은, 강희태, 권지원, 김수영, 김수진, 김영호, 김유미, 김환철, 백영욱, 범은애, 사공준, 서주희, 손미아, 양송이, 오경재, 이기재, 이철갑, 임신예, 정해관, 조현주, 하미나, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제4호알레르기비염을 가진 소아의 천식 증상 발생과 관련된 위험 인자권지원, 김효빈, 박유미, 서주희, 이소연, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2020 · 제8권 제4호알레르기비염과 형제자매와의 연관성권지원, 김병주, 김우경, 김은진, 김형영, 김효빈, 서주희, 송대진, 심정연, 이소연, 이주실, 장광천, 정영호, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제1호소아 알레르기비염의 위험 인자와 보호 인자박양, 대한 소아알레르기 호흡기학회 비염 연구회, 김민지, 김현희, 김효빈, 나영호, 박용민, 성명순, 신윤호, 염혜영, 이경석, 이용주, 전윤홍, 지혜미, 최봉석, 최선희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2022 · 제10권 제2호천식 환아에서 집먼지진드기 감작이 기도과민성과 폐기능에 미치는 영향김은옥, 박강서, 진소희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2007 · 제17권 제4호6-8세 소아에서 항원 감작과 기관지 과민성의 관계강희, 유영, 고영률, 김도균, 유진호, 최선희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2005 · 제15권 제4호

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