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Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea

김영훈|안혜진|김동재|남호우|김화선
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2022.08|Parasites, Hosts and Diseases|제60권 제4호|pp. 261-271|DOI 10.3347/kjp.2022.60.4.261

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참고문헌

키워드

clusterClonorchiasisHIRAspatiotemporal analysischolangiocarcinomaSaTScan
주제분류예방의학/직업환경의학

초록

This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR=4.55, Likelihood Ratio; LLR=9,131.115) joint cluster and Seoul (RR=2.29, LLR=7,602.472), respectively. The MLC for clonorchiasis was in the southeastern part of Korea, while that for CCA was in the southern part. Clonorchiasis showed a decreasing trend in the southeastern districts, while increased in the southwestern districts. Cities in the central region had a decreasing trend, while the western districts had an increasing trend. In most adults (30-59), infection rate of clonorchiasis showed a significant decrease until 2018, while thereafter increased, although not significant. CCA showed a sharply decreasing tendency. The incidence of clonorchiasis and CCA were positively correlated. In general, the correlation was weak (r=0.39, P<0.001), but it was strongly positive around the 4 river basins (r=0.74, P<0.001). This study might provide an analytic basis for developing an effective system against clonorchiasis and CCA.

Abstract

This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR=4.55, Likelihood Ratio; LLR=9,131.115) joint cluster and Seoul (RR=2.29, LLR=7,602.472), respectively. The MLC for clonorchiasis was in the southeastern part of Korea, while that for CCA was in the southern part. Clonorchiasis showed a decreasing trend in the southeastern districts, while increased in the southwestern districts. Cities in the central region had a decreasing trend, while the western districts had an increasing trend. In most adults (30-59), infection rate of clonorchiasis showed a significant decrease until 2018, while thereafter increased, although not significant. CCA showed a sharply decreasing tendency. The incidence of clonorchiasis and CCA were positively correlated. In general, the correlation was weak (r=0.39, P<0.001), but it was strongly positive around the 4 river basins (r=0.74, P<0.001). This study might provide an analytic basis for developing an effective system against clonorchiasis and CCA.

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관련 논문AI추천

Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review김동수, 김종보, 박영일, 박장호생화학분자생물학회 · BMB Reports2016 · 제49권 제11호Risk Factors of Clonorchis sinensis Human Infections in Endemic Areas, Haman-Gun, Republic of Korea: A Case-Control Study김양희, 이명노, 이상은, 조신형, 주정원, Hee-Eun Shin대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2020 · 제58권 제6호Prevalence of Clonorchis sinensis Infection among Residents along 5 Major Rivers in the Republic of Korea김정연, 박미연, 전형일, 조신형, 주정원, Hee-Eun Shin, Sang-Eun Lee, Young-Il Jeong대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2016 · 제54권 제2호Prevalence of Clonorchis sinensis Metacercariae in Freshwater Fish from Three Latitudinal Regions of the Korean Peninsula공윤, 김동수, 나병국, 석원석, 손운목, 엄기선, 조신형, Taejoon Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2011 · 제49권 제4호Prevalence of Clonorchiasis in Southern Endemic Areas of Korea in 2006김동수, 손운목, 이기연, 이병철, 전형일, 조신형, 조표연, 홍성태대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2008 · 제46권 제3호Update on the risk factors for opisthorchiasis and cholangiocarcinoma in ThailandAnthicha Kunjantarachot, Junya Pattaraarchachai, Jutharat Kulsantiwong, Kritiya Butthongkomvong, Montinee Pholhelm, Sattrachai Prasopdee, Siraphatsorn Yusuk, Smarn Tesana, Teva Phanaksri, Thanakrit Sathavornmanee, Thittinan Rojthongpond, Veerachai Thitapakorn, Yanwadee Chitkoolsamphan대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2023 · 제61권 제4호

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