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Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review

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Parasitic diseases remain an unarguable public health problem worldwide. Liver fluke Clonorchis sinensis is a high risk pathogenic parasitic helminth which is endemic predominantly in Asian countries, including Korea, China, Taiwan, Vietnam, and the far eastern parts of Russia, and is still actively transmitted. According to the earlier 8th National Survey on the Prevalence of Intestinal Parasitic Infections in 2012, C. sinensis was revealed as the parasite with highest prevalence of 1.86% in general population among all parasite species surveyed in Korea. This fluke is now classified under one of the definite Group 1 human biological agents (carcinogens) by International Agency of Research on Cancer (IARC) along with two other parasites, Opisthorchis viverrini and Schistosoma haematobium. C. sinensis infestation is mainly linked to liver and biliary disorders, especially cholangiocarcinoma (CCA). For the purposes of this mini-review, we will only focus on C. sinensis and review pathogenesis and carcinogenesis of clonorchiasis, disease condition by C. sinensis infestation, and association between C. sinensis infestation and CCA. In this presentation, we briefly consider the current scientific status for progression of CCA by heavy C. sinensis infestation from the food-borne trematode and development of CCA.

Abstract

Parasitic diseases remain an unarguable public health problem worldwide. Liver fluke Clonorchis sinensis is a high risk pathogenic parasitic helminth which is endemic predominantly in Asian countries, including Korea, China, Taiwan, Vietnam, and the far eastern parts of Russia, and is still actively transmitted. According to the earlier 8th National Survey on the Prevalence of Intestinal Parasitic Infections in 2012, C. sinensis was revealed as the parasite with highest prevalence of 1.86% in general population among all parasite species surveyed in Korea. This fluke is now classified under one of the definite Group 1 human biological agents (carcinogens) by International Agency of Research on Cancer (IARC) along with two other parasites, Opisthorchis viverrini and Schistosoma haematobium. C. sinensis infestation is mainly linked to liver and biliary disorders, especially cholangiocarcinoma (CCA). For the purposes of this mini-review, we will only focus on C. sinensis and review pathogenesis and carcinogenesis of clonorchiasis, disease condition by C. sinensis infestation, and association between C. sinensis infestation and CCA. In this presentation, we briefly consider the current scientific status for progression of CCA by heavy C. sinensis infestation from the food-borne trematode and development of CCA.

참고문헌 (80)

  1. Histological typing of tumors of the liver biliary tract and pancreas, "Gibson JB", World Health Organization, ~ (1978)
  2. Blechacz B, "Cholangiocarcinoma : Advances on pathogenesis, diagnosis, and treatment", Hepatol, 48, pp.308~321 (2008)
  3. Bouvard V, "A review of human carcinogens-Part", Lancet Oncol, 10, pp.321~322 (2009)
  4. Sripa B, "Liver fluke induces cholangiocarcinoma", PLoS Med, 4, pp.e201~ (2007)
  5. Oh J-K, "Infection and cancer:Global distribution and burden of diseases", Ann Glob Health, 80, pp.384~392 (2014)
  6. Choi D, "Cholangiocarcinoma and Clonorchis sinensis infection: A care-control study in Korea", J Hepatol, 44, pp.1066~1073 (2006)
  7. Lim MK, "Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea", Am J Trop Med Hyg, 75, pp.93~96 (2006)
  8. Honjo S, "Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand", Int J Cancer, 117, pp.854~860 (2005)
  9. Monographs on the evaluation of carcinogenic risks to humans. A review of carcinogen - Part B: Biological Agents, "International Agency for Research on Cancer", ~ (2011)
  10. 신해림, "Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea", Journal of Korean Medical Science, 25(7), pp.1011~1016 (2010), 대한의학회
  11. Viranuvatti V, "Retention cyst of liver caused by opisthorchiasis associated with carcinoma; Case report", Am J Gastroenterol, 23, pp.442~446 (1955)
  12. Hou PC, "Relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis", J Pathol Bacteriol, 72, pp.239~246 (1956)
  13. Huang S-Y, "Genomics and molecular genetics of Clonorchis sinensis: Current status and perspectives", Parasitol Int, 61, pp.71~76 (2012)
  14. Vennervald BJ, "Helminths and malignancy", Parasite Immunol, 31, pp.686~696 (2009)
  15. Lim MK, "Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea", Am J Trop Med Hyg, 75, pp.93~96 (2006)
  16. Sripa B, "The tumorigenic liver fluke Opisthorchis viverrini – Multiple pathways to cancer", Trends Parasitol, 28, pp.395~407 (2012)
  17. Chai JY, "Fish-borne parasitic zoonoses: Status and issues", Inter J Parasitol, 35, pp.1233~1254 (2005)
  18. Hong S-T, "Clonorchis sinensis and clonorchiasis, an update", Parasitol Int, 61, pp.17~24 (2012)
  19. Qian M-B, "Clonorchiasis", Lancet, 387, pp.800~810 (2016)
  20. Kim JH, "Correlation between discharged worms and fecal egg counts in human clonorchiasis", PLoS Negl Trop Dis, 5, pp.e1339~ (2011)
  21. Qiao T, "Cholecystollithiasis is associated with Clonorchis sinensis infection", PLoS One, 7, pp.e42471~ (2012)
  22. Wills-Karp M, "The germless theory of allergic disease: Revisiting the hygiene hypothesis", Nat Rev Immunol, 1, pp.69~75 (2001)
  23. Okada H, "The ‘hygiene hypothesis’ for autoimmune and allergic", An update. Clin Exper Immunol, 160, pp.1~9 (2010)
  24. Fallon PG, "Suppression of TH2-type allergic reactions by helminth infection", Nat Rev Immunol, 7, pp.220~230 (2007)
  25. Jeong Y-I, "Clonorchis sinensisderived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions", Biochem Biophys Res Comm, 407, pp.793~800 (2011)
  26. Jeong Y-I, "Identification of anti-allergic effect of Clonorchis-derived protein venom allergen-like proteins(CsVAL)", Biochem Biophys Res Comm, 445, pp.549~555 (2014)
  27. Dunne DW, "A worm’s eye view of the immune system: Consequences for evolution of human autoimmune diseases", Nat Rev Immunol, 5, pp.420~426 (2005)
  28. Rim HJ, "Clinical evaluation of the therapeutic efficacy of paraziquantel (Embay 8440)against Clonorchis sinensis infection in man", Ann Trop Med Parasitol, 75, pp.27~33 (1981)
  29. Ambroise-Thomas P, "Parasitological examinations and immunodiagnostic advances in fluke infection", Arzneimittelforschung, 34, pp.1129~1132 (1984)
  30. Kang J-M, "Mapping the putative epitope domain of Clonorchis sinensis paramyosin(CsPmy)recognized by CsPmy-specific immunoglobulin G in sera of human clonorchiasis", Mol Biochem Parasitol, 201, pp.66~71 (2015)
  31. 김태임, "Functional Genes and Proteins of Clonorchis sinensis", The Korean Journal of Parasitology, 47, pp.59~68 (2009), 대한기생충학ㆍ열대의학회
  32. Park GM, "Genetic comparison of liver flukes, Clonorchis sinensis and Opisthorchis viverrini based on rDNA and mtDNA gene sequences", Parasitol Res, 100, pp.351~357 (2007)
  33. Lim JH, "Radiologic findings of clonorchiasis", Am J Roentgenol, 155, pp.1001~1008 (1990)
  34. Xiao SH, "Tribendimidine : A promising, safe and broad-spectrum anthelmintic agent from China", Acta Trop, 94, pp.1~14 (2005)
  35. Echaubard P, "The role of evolutionary biology in research and control of liver flukes in southeast Asia", Infect Genet Evol (2016)
  36. Prevalence of intestinal parasitic infections in Korea - The 8th report, "Korean National Research Institute of Health, Centers for Disease Control & Prevention", ~ (2013)
  37. Prevalence of intestinal parasitic infection in Korea - The 7th report, "Ministry of Health and Welfare, Korea Association of Health Promotion", ~ (2004)
  38. Young-Il Jeong, "Prevalence of Clonorchis sinensis Infection among Residents along 5 Major Rivers in the Republic of Korea", The Korean Journal of Parasitology, 54(2), pp.215~219 (2016), 대한기생충학ㆍ열대의학회
  39. Li T, "Major trends in human parasitic diseases in China", Trends Parasitol, 26, pp.264~270 (2010)
  40. Hong ST, "Changes of histopathological and serological findings of the liver after treatment in rabbit clonorchiasis", Seoul J Med, 31, pp.117~127 (1990)
  41. Min HK, "Clonorchis sinensis: Pathogenesis and clinical features of infection", Arzneimittelforschung, 34, pp.1151~1153 (1984)
  42. Kim YJ, "Proliferative effects of excretory", secretory products from Clonorchis sinensis on the human epithelial cell line HEK293 via regulation of the transcription factor E2F1, 2008, pp.102, 411~417
  43. Kim YJ, "Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis", Parasitol Res, 104, pp.1011~1016 (2009)
  44. Yoo WG, "Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis", PLoS Neg Trop Dis, 5, pp.e1208~ (2011)
  45. Fava G, "Molecular pathogenesis of cholangiocarcinoma", Int J Hepatol Article, 2012, pp.630543~ (2012)
  46. Kawanishi S, "Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation", Antioxid Redox Signal, 8, pp.1047~1058 (2006)
  47. Maeng A, "Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection", Int J Parasitol, 46, pp.195~204 (2016)
  48. Kawai T, "Toll-like receptors and their crosstalk with other innate receptors in infection and immunity", Immunity, 34, pp.637~650 (2011)
  49. Yan C, "Expression of Toll-like receptor(TLR)2 and TLR4 in the livers of mice infected by Clonorchis sinensis", J Infect Dev Ctries, 9, pp.1147~1155 (2015)
  50. Liu Q, "The molecular mechanisms of TLR-signaling cooperation in cytokine regulation", Immunol Cell Biol (2016)
  51. Choi YK, "Cytokine responses in mice infected with Clonorchis sinensis", Parasitol Res, 91, pp.87~93 (2003)
  52. Kim EM, "Cyst formation, increased anti-inflammatory cytokines and expression of chemokines support for Clonorchis sinensis infection in FVB mice", Parasitol Int, 61, pp.124~129 (2012)
  53. Bhamarapravati N, "Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini", Am J Trop Med Hyg, 38, pp.356~362 (1978)
  54. Choi BI, "Clonorchiasis and cholangiocarcinoma: Etiologic relationship and imaging diagnosis", Clin Microbiol Rev, 17, pp.540~552 (2004)
  55. 최민호, "Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA", The Korean Journal of Parasitology, 41(1), pp.35~39 (2003), 대한기생충학ㆍ열대의학회
  56. Pak JH, "Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products", Parasitol Res, 104, pp.1011~1016 (2009)
  57. Kim D-W, "Transcriptional induction of minichromosome maintenance protein 7(Mcm7)in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products", Mol Biochem Parasitol, 173, pp.10~16 (2010)
  58. Pak JH, "Proteomic analysis of differentially expressed proteins in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products", J Cell Biochem, 108, pp.1376~1388 (2009)
  59. Pak JH, "Induction of cancer-related microRNA expression profiling using excretory-secretory products of Clonorchis sinensis", Parasitol Res, 113, pp.4447~4455 (2014)
  60. Ju JW, "Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms", Proteomics, 9, pp.3066~3078 (2009)
  61. Khurana S, "Association of parasitic infections and cancers", Indian J Med Microbiol, 23, pp.74~79 (2005)
  62. Oshima H, "Increased nitrosamine and nitrate biosynthesis mediated by nitric oxide synthase induced in hamsters infected with liver fluke(Opisthorchis viverrini)", Carcinogenesis, 15, pp.271~275 (1994)
  63. Qing-Li Yang, "Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis", The Korean Journal of Parasitology, 53(6), pp.777~783 (2015), 대한기생충학ㆍ열대의학회
  64. Pinlaor S, "Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2’-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase", Carcinogenesis, 25, pp.1535~1542 (2004)
  65. Nam J-H, "Free radicals enzymatically triggered by Clonorchis sinensis excretorysecretory products cause NF-κB-mediated inflammation in human cholangiocarcinoma cells", Int J Parasitol, 42, pp.103~113 (2012)
  66. Esquela-Kerscher A, "Oncomirs –MicroRNAs with a role in cancer", Nat Rev, 6, pp.259~269 (2006)
  67. Namwat N, "Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma", Asian Pac J Cancer Prev, 13, pp.65~69 (2012)
  68. Braconi C, "MicroRNAdependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocyte", Hepathol, 51, pp.881~890 (2010)
  69. Oshima H, "Chronic infectious and inflammation processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis", Mutat Res, 305, pp.253~264 (1994)
  70. Weitzman SA, "Inflammation and cancer: Role of phagocyte-generated oxidants in carcinogenesis", Blood, 76, pp.655~663 (1990)
  71. Apte RN, "Interleukin-1 – A major pleiotropic cytokine in tumor host interactions", Cancer Biol, 12, pp.277~290 (2002)
  72. Ishimura N, "Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth", Gastrointest Liver Physiol, 287, pp.G88~G95 (2004)
  73. Lowenstein CJ, "iNOS(NOS2)at a glance", J Cell Sci, 117, pp.2865~2867 (2004)
  74. Bartsch H, "Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer:Role of lipid peroxidation, DNA damage and Repair", Langenbeck’s Arch Surg, 391, pp.499~510 (2006)
  75. Reuter S, "Oxidative stress, inflammation and cancer: How are they linked?", Free Radical Biol Med, 49, pp.1603~1616 (2010)
  76. Fitzpatrick FA, "Inflammation, carcinogenesis and cancer", Int Immunopharmacol, 1, pp.1651~1667 (2001)
  77. Furstenberger G, "What are cyclooxygenases and lipoxygenases doing in the driver’s seat of carcinogenesis?", Int J Cancer, 119, pp.2247~2254 (2006)
  78. Brown JR, "COX-2 : A molecular target for colorectal cancer prevention", J Clin Oncol, 23, pp.2840~2855 (2005)
  79. 김은민, "Effects of Excretory", Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells, 2008, pp.46(3), 127~132[DOI]
  80. Uddin MH, "Involvement of PSMD10, CDK4 and tumor suppressors in development of intrahepatic cholangiocarcinoma of Syrian golden hamsters induced by Clonorchis sinensis and N-Nnitrosodimethylamine", PLoS Negl Trop Dis, 9, pp.e0004008~ (2015)

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