Risk Factors of Clonorchis sinensis Human Infections in Endemic Areas, Haman-Gun, Republic of Korea: A Case-Control Study
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Clonorchis sinensis is the most common fish-borne intestinal parasite in Korea. The aim of the present investi- gation was to survey the status of C. sinensis infection and analyze associated risk factors in residents of Haman-gun, Gyeongsangnam-do. A total of 5,114 residents from 10 administrative towns/villages voluntarily agreed to participate in the study, which comprised fecal examination, a questionnaire survey for risk factors, ultrasonography, and enzyme- linked immunosorbent assay for cancer biomarker detection in the blood. We detected C. sinensis eggs in 5.3% of the subjects. By region, Gunbuk-myeon had the highest number of residents with C. sinensis eggs. The infection rate and in- tensity were higher in male than in female residents. Based on the risk factor questionnaire, infection was highly associat- ed with drinking, a history of C. sinensis infection, and the practice of eating of raw freshwater fish. Extension of the bile duct, infection intensity, and cancer biomarker detection significantly correlated with the presence of eggs in the study population. In conclusion, the development of feasible, long-term control policies and strategies for the elimination of C. sinensis in Korea is still required.
Abstract
Clonorchis sinensis is the most common fish-borne intestinal parasite in Korea. The aim of the present investi- gation was to survey the status of C. sinensis infection and analyze associated risk factors in residents of Haman-gun, Gyeongsangnam-do. A total of 5,114 residents from 10 administrative towns/villages voluntarily agreed to participate in the study, which comprised fecal examination, a questionnaire survey for risk factors, ultrasonography, and enzyme- linked immunosorbent assay for cancer biomarker detection in the blood. We detected C. sinensis eggs in 5.3% of the subjects. By region, Gunbuk-myeon had the highest number of residents with C. sinensis eggs. The infection rate and in- tensity were higher in male than in female residents. Based on the risk factor questionnaire, infection was highly associat- ed with drinking, a history of C. sinensis infection, and the practice of eating of raw freshwater fish. Extension of the bile duct, infection intensity, and cancer biomarker detection significantly correlated with the presence of eggs in the study population. In conclusion, the development of feasible, long-term control policies and strategies for the elimination of C. sinensis in Korea is still required.
참고문헌 (16)
- National survey of the prevalence of Intestinal Parasitic Infections in Korea, "Korea Centers for Disease Control and Prevention", Korea Center for Disease Control and Prevention, ~ (2013)
- Qian MB, "Clonorchiasis", Lancet, 387, pp.800~810 (2016)[DOI]
- Annual Report of Cancer Statistics in Korea in 2016, "Korea Central Cancer Registry, National Cancer Center", Ministry of Health and Welfare, ~ (2018)
- Choi MS, "Correlation between sonographic findings and infection intensity in clonorchiasis", Am J Trop Med Hyg, 73, pp.1139~1144 (2005)
- Malaguarnera G, "Serum markers of intrahepatic cholangiocarcinoma", Dis Markers, 34, pp.219~228 (2013)[DOI]
- Banales JM, "Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma, and primary sclerosing cholangitis", Hepatology, 70, pp.547~562 (2019)[DOI]
- June KJ, "Prevalence and risk factors of clonorchiasis among the populations served by primary healthcare posts along five major rivers in South Korea", Osong Public Health Res Perspect, 4, pp.21~26 (2013)[DOI]
- Shin HE, "Epidemiological and clinical parameters features of patients with clonorchiasis in the Geum river basin, Republic of Korea", Interdiscip Perspect Infect Dis, 2017, pp.7415301~ (2017)[DOI]
- Vinh HQ, "Risk factors for Clonorchis sinensis infection transmission in humans in northern Vietnam : a descriptive and social network analysis study", Parasitol Int, 66, pp.74~82 (2017)[DOI]
- 박도순, "Prevalence and risk factors of clonorchiasis among residents of riverside areas in Muju-gun, Jeollabuk-do, Korea", Parasites, Hosts and Diseases, 52(4), pp.391~397 (2014), 대한기생충학ㆍ열대의학회[DOI]
- The International Agency for Research on Cancer, "Opisthorchis viverrini and Clonorchis sinensis. IARC, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 100B, A Review of Human Carcinogens: Biological Agents", pp.341~370 (2012), IARC
- Bouvard V, "A review of human carcinogens--Part B : biological agents", Lancet Oncol, 10, pp.321~322 (2009)[DOI]
- 정병석, "Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis", Parasites, Hosts and Diseases, 47(2), pp.145~151 (2009), 대한기생충학ㆍ열대의학회
- 최동일, "Imaging diagnosis of clonorchiasis", Parasites, Hosts and Diseases, 45(2), pp.77~85 (2007), 대한기생충학ㆍ열대의학회
- Wongkham S, "State of Serum Markers for Detection of Cholangiocarcinoma", Asian Pac J Cancer Prev, 13, pp.17~27 (2012)
- Wang B, "Potential diagnostic biomarkers for cholangiocarcinoma in serum and bile", Biomark Med, 10, pp.613~619 (2016)[DOI]