Nocturnal Sleep Related with Metabolic Markers in End-Stage Renal Disease Patients Receiving Hemodialysis
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Objective: It has been suggested that oxidative stress and inflammation are associated with the pathophysiology of sleep disorders in end-stage renal disease (ESRD) patients. We examined the relationship of the sleep variables reflecting sleep breathing disorder and limb movements during sleep with the clinical variables reflecting the metabolic abnormalities in ESRD patients receiving hemodialysis. Methods: Nocturnal polysomnography was conducted in 30 ESRD patients (21 men, 9 women), who were receiving hemodialysis. Blood was sampled before hemodialysis for each patient in order to measure uric acid (UA), C-reactive protein (CRP), and interleukin -6 (IL-6). Results: UA was correlated positively with the total sleep time (TST)(r=0.407) and negatively with the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI)(r=-0.377, -405). Conclusion: CRP was positively correlated with the limb movement index (LMI)(r=0.401). Our study showed that increased UA was related to decreased respiratory disturbance during sleep in ESRD patients receiving hemodialysis.
Abstract
Objective: It has been suggested that oxidative stress and inflammation are associated with the pathophysiology of sleep disorders in end-stage renal disease (ESRD) patients. We examined the relationship of the sleep variables reflecting sleep breathing disorder and limb movements during sleep with the clinical variables reflecting the metabolic abnormalities in ESRD patients receiving hemodialysis. Methods: Nocturnal polysomnography was conducted in 30 ESRD patients (21 men, 9 women), who were receiving hemodialysis. Blood was sampled before hemodialysis for each patient in order to measure uric acid (UA), C-reactive protein (CRP), and interleukin -6 (IL-6). Results: UA was correlated positively with the total sleep time (TST)(r=0.407) and negatively with the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI)(r=-0.377, -405). Conclusion: CRP was positively correlated with the limb movement index (LMI)(r=0.401). Our study showed that increased UA was related to decreased respiratory disturbance during sleep in ESRD patients receiving hemodialysis.
참고문헌 (27)
- Walker S, "Sleep complaints are common in a dialysis unit", Am J Kidney Dis, 26, pp.751~756 (1995)
- Parker KP, "Daytime sleepiness in stable hemodialysis patients", Am J Kidney Dis, 41, pp.394~402 (2003)
- Kimmel PL, "Sleep apnea syndrome in chronic renal disease", Am J Med, 86, pp.308~314 (1989)
- Benz RL, "Potential novel predictors of mortality in end-stage renal disease patients with sleep disorders", Am J Kidney Dis, 35, pp.1052~1060 (2000)
- Parker KP, "Sleep disturbances in dialysis patients", Sleep Med Rev, 7, pp.131~143 (2003)
- Spittle MA, "Oxidative stress and inflammation in hemodialysis patients", Am J Kidney Dis, 38, pp.1408~1413 (2001)
- Kokturk O, "Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome", Int Heart J, 46, pp.801~809 (2005)
- Söreide E, "Branched-chain amino acid in chronic renal failure patients: respiratory and sleep effects", Kidney Int, 40, pp.539~543 (1991)
- Hasegawa T, "A new role of uric acid as an antioxidant in human plasma", Rinsho Byori, 37, pp.1020~1027 (1989)
- "NKF-K", DOQI Clinical Practice Guidelines for Hemodialysis Adequacy:update 2000, 2001, pp.37, S7~S64
- Johns MW, "Reliability and factor analysis of the Epworth Sleepiness Scale", Sleep, 15, pp.376~381 (1992)
- Douglass AB, "The Sleep Disorders Questionnaire. I: Creation and multivariate structure of SDQ", Sleep, 17, pp.160~167 (1994)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental disorders. in: Text revision", pp.345~428 (2000), American Psychiatric Association
- Rechtschaffen A, "A manual of standardized terminology, technique, and scoring system of sleep stages of human subjects", pp.1968, BIS
- American Academy of Sleep Medicine, "International classification of sleep disorders, revised.: diagnostic and coding manual" (1997), American Sleep Disorders Association
- Rijsman RM, "Periodic limb movement disorder and restless legs syndrome in dialysis patients", Nephrology, 9, pp.353~361 (2004)
- Sahebajani H, "Changes in urinary uric acid excretion in obstructive sleep apnea before and after therapy with nasal continuous positive airway pressure", Chest, 113, pp.1604~1608 (1998)
- Dimitroula HV, "The role of uric acid in stroke: the issue remains unresolved", Neurologist, 14, pp.238~242 (2008)
- Sautin YY, "Uric acid: the oxidant-antioxidant paradox", Nucleosides Nucleotides Nucleic Acids, 27, pp.608~619 (2008)
- Verhulst SL, "Sleep-disordered breathing and uric acid in overweight and obese children and adolescents", Chest, 132, pp.76~80 (2007)
- Hsu SP, "Serum uric acid levels show a ‘J-shaped’ association with all-cause mortality in haemodialysis patients", Nephrol Dial Transplant, 19, pp.457~462 (2004)
- Christou K, "Gourgoulianis KI. Antioxidant capacity in obstructive sleep apnea patients", Sleep Med, 4, pp.225~228 (2003)
- Jung HH, "Sleep apnea, coronary artery disease, and antioxidant status in hemodialysis patients", Am J Kidney Dis, 45, pp.875~882 (2005)
- Halliwell B, "Albumin-an important extracellular antioxidant?", Biochem Pharmacol, 37, pp.569~571 (1988)
- Rousseau Y, "In vivo intracellular cytokine production by leukocytes during hemodialysis", Cytokine, 12, pp.506~517 (2000)
- Hoeger S, "Dopamine treatment in brain-dead rats mediates anti-inflammatory effects:the role of hemodynamic stabilization and D-receptor stimulation", Transpl Int, 20, pp.790~799 (2007)
- Earley CJ, "Clinical practice. Restless legs syndrome", N Engl J Med, 348, pp.2103~2109 (2003)