혈액투석을 받는 만성신부전 환자의 수면장애의 특성 및 임상변인과의 상관관계
Characteristics of Sleep Disturbances Correlated with Clinical Parameters in Hemodialysis Patients with Chronic Renal Failure
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Abstract
Objectives:Sleep disturbances are very common in hemodialysis (HD) patients with chronic renal failure (CRF). This study aimed to examine the characteristics of sleep disturbances, and to illustrate the relationship of sleep parameters with clinical parameters reflecting metabolic dysfunction in HD patients with CRF. Methods:The Epworth Sleepiness Scale (ESS) and Sleep Disorders Questionnaire (SDQ) were administered in 26 HD patients with CRF. For fifteen patients with the risk of sleep disorder, nocturnal polysomnographic study (NPSG) and blood sampling were done. Results:Among 15 patients, 14 patients (93%) were diagnosed as sleep disorders, sleep breathing disorder or periodic limb movements in sleep. Uric acid (UA) was positively correlated with sleep efficiency (r=0.571), and negatively correlated with waking after sleep onset, the amount of stage 1 sleep, and respiratory disturbance index (r=-0.515, -0.564, -0.646). Interleukin- 6 was positively correlated with obstructive apnea index (r=0.661). Conclusion:In our study, the difficulty in maintaining sleep was found in HD patients with CRF. It also showed that increased UA was associated with improved sleep maintenance and decreased breathing disturbance during sleep. This might be related with antioxidant effect of UA in CRF. Further studies on total CRF patients including those without the risk of sleep disorder are necessary.
참고문헌 (47)
- "Sleep complaints are common in adialysis unit", 26, pp.751~756 (1995)
- "Obstructive sleep apnea and the kidney", 4, pp.1111~1121
- "Periodic K-alphasleep EEG activity and periodic limb movements during sleep:comparisonsof clinical features and sleep parameters", 19, pp.200~204 (1996)
- "A comparison of sleep-disordered respirationin ESRD patients receiving hemodialysis and peritoneal dialysis", 8, pp.195~198 (1992)
- "Theoccurrence of sleep-disordered breathing among middle-aged adults", 328, pp.1230~1235 (1993)
- "Clinical comparison of hemodialysis and sleepapnea patients with excessive daytime sleepiness", 24, pp.663~665 (1997)
- "Potential novelpredictors of mortality in end-stage renal disease patients with sleepdisorders", 35, pp.1052~1060 (2000)
- "Changes in depressive symptoms after continuouspositive airway pressure treatment for obstructive sleep apnea", 7, pp.31~42 (2003)
- "A preliminarystudy of the effects of correction of anemia with recombinant humanerythropoietin therapy on sleep,sleep disorders,and daytime sleepinessin hemodialysis patients", 34, pp.1089~1095 (1999)
- "Sleep apnea incidence inmaintenance hemodialysis patients:influence of dialysate buffer", 71, pp.138~142 (1995)
- "Comparison of sleep-disorderedrespiration in ESRD patients receiving hemodialysis and peritonealdialysis", 8, pp.195~198 (1992)
- "Electrophysiological andneurobehavioral responses to therapy:The National Cooperative DialysisStudy", 13, pp.58~65 (1983)
- "In vivo intracellular cytokine production by leukocytes duringhaemodialysis", 12, pp.506~517 (2000)
- "Harrison’s principles of internal medicine", pp.1551~1567 (2001), The McGraw-Hill Companies
- "Sleep qualityand clinical correlates in patients on maintenance dialysis", 59, pp.280~288
- "Andreucci.Insomnia in maintenance haemodialysis patients", 17, pp.852~856 (2002)
- "혈액투석요법 환자의 우울,불안 및 수면장애에 대한 연구", 38, pp.997~1005 (1999)
- "혈액투석 중인 만성 신부전증 환자에서의 불면증에 대한 연구", 6, pp.126~132 (1999)
- "Beck depressionInventory의 한국판 표준화 연구-정상집단을 중심으로(1)", 25, pp.487~502 (1986)
- "Reliablility and factor analysis of the Epworth SleepinessScale", 15, pp.376~381 (1992)
- "The Sleep Disorders Questionnaire I:Creation andmultivariate structure of SDQ", 17, pp.160~167 (1994)
- "A new for measuring daytime sleepiness:The EpworthSleepiness Scale", 14, pp.540~545 (1991)
- "정상인과 수면장애 환자군 간의 주간졸림증 비교 및 임상적 의미 분석", 9, pp.106~114 (2002)
- "Sleep and reported daytime sleepiness in normalsubjects:the Sleep Heart Health Study", 27, pp.293~298 (2004)
- "Sleep Disturbance inPatients on Hemodialysis Versus Medically Managed Patients withSevere Chronic Kidney Disease", 27 (2004)
- "A manual of standardized terminology and scoring system of sleep stages of human subjects" (1968)
- "Principles andPractices of Sleep Medicine", pp.15~24 (1994)
- "Are periodic leg movements associated with clinicalsleep disturbance", 19, pp.219~223 (1996)
- "Sleep apnoea syndrome inchronic renal disease", 86, pp.308~314 (1989)
- "Changes in urinary uric acid excretion in obstructivesleep apnea before and after therapy with nasal continuous positiveairway pressure", 113, pp.1604~1608 (1998)
- "Uric acid excretion:Quantitative assessment from spot,midmorning serum and urine samples", 91, pp.44~47 (1979)
- "Nocturnal increase of urinary uric acid A biochemical correlate of sleep-associated hypoxaemia", pp.534~538
- "3-diphosphoglycerate inpatients with obstructive sleep apnea", pp.8~13
- "Creatinineratio for detection of sleep hypoxaemia Validation study in chronicobstructive pulmonary disease and obstructive sleep apnea beforeand after treatment with nasal continuous positive airway pressure", pp.173~178
- "Oxidative stress and inflammation in hemodialysis patients", 38, pp.1408~1413 (2001)
- "Correlation studies of plasma paraoxonase activity anduric acid concentration with AAPH-induced erythrocyte hemolysis inhemodialysis patients", 28, pp.259~264 (2004)
- "Antioxidantcapacity in obstructive sleep apnea patients", 4, pp.225~228 (2003)
- "Uric acid providesantioxidant defense in humans against oxidant-and radical-caused agingand cancer:A hypothesis", 78, pp.6858~6862 (1981)
- "A new role of uric acid as an antioxidant inhuman plasma", 37, pp.1020~1207 (1989)
- "Normalization ofoxidative stress parameters after kidney transplant is secondary to fullrecovery of renal function", 62, pp.131~137 (2004)
- "Restless legs syndrome in hemodialysis patients in India:A case controlledstudy", 4, pp.143~146 (2003)
- "Ferritin protects endothelial cells from oxidized low density lipoproteinin vitro", 147, pp.782~789 (1995)
- "Obstructive sleep apnea,inflammation,and cardiopulmonary disease", 9, pp.2892~2900 (2004)
- "Increased prevalence of oxidant stress andinflammation in patients with moderate to severe chronic kidney disease", 65, pp.1009~1016 (2004)
- "Association between circulating inflammatory markers and residualrenal function in CRF patients", 41, pp.1212~1218 (2003)
- "Restlesslegs syndrome in patients on chronic hemodialysis in a Braziliancity:Frequency,biochemical findings and comorbidities", 61, pp.723~727 (2003)
- "Prevalenceof sleep disturbances in chinese patients with end-stage renalfailure on continuous ambulatory peritoneal dialysis", 36, pp.783~788 (2000)
