본문 바로가기
KERD
논문

홍삼의 장기 투여가 흰쥐 간 대사효소 유도에 미치는 영향

*Modulation of Cytochrome P-450 Induction by Long-Term Supplementation with Korean Red Ginseng to Rats.

임흥빈
한국약용작물학회|2007.12|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제6호|pp. 437-443

0

조회

0

다운로드

1

인용

0

참고문헌

초록

Abstract

ABSTRACTS : This study was carried out to investigate the effect of dietary supplementation with red ginseng waterextracts on the induction of microsomal cytochrome P-450 in rats. Phenobarbital (PB) and 3-methylcholanthrene (3-MC), P-450 inducers, were administered to 3- or 12-month old rats received red ginseng extracts (25 mg/kg) from 6 weeks to 12 months for 3 days. PB and 3-MC increased levels of P-450, P-450 reductase, ethoxycoumarin O-deethylase, benzphetamine N-demethylase and glutathione-S-transferase in the liver of rats. However, chronic administration of red ginseng significantly reduced these increase of enzyme levels induced by P-450 inducers. Chronic administration of red ginseng did not affect the induction of cytochrome b5 and NADH cytochrome b5 reductase by P-450 inducers. It is suggested that the induction of cytochrome P-450 system in the liver in relation to xenobiotics toxicity can be modulated by long-term supplementation with Korean red ginseng to rats.

참고문헌 (23)

  1. "In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP 1A2, and CYP 1B1", 30(4), pp.378~384 (2002)
  2. "The metabolism ofmethylated aminoazo dyes. V. Evidence for induction ofenzyme synthesis in the rat by 3-methylcholanthrene. CancerRes. 16", pp.450~459 (1956)
  3. "An improved assay of 7-ethoxycoumarine O-deethylase activity. Induction of hepaticenzyme activity in C57BL", 6J and DBA, pp.1978[DOI]
  4. "Glutathione-Stransferase.The first enzymatic step in mercapturic acidformation. J. Biol. Chem. 249", pp.7130~7139 (1974)
  5. "Complex reactions catalyzed by cytochrome P450 enzymes", 1770(3), pp.314~329 (2007)
  6. "Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5", 19(10), pp.1366~1373 (2006)
  7. "In vivo effects of Panax ginseng extracts on the cytochrome P450-dependnet monooxygenase system in the liver of 2,3,7,8-tetrachlorodibebzo-p-dioxin-exposed guinea pig", 71(7), pp.759~769 (2002)
  8. "The effect of water-extract of Epimedium koreanum Nakai on age-related changes of the xenobiotic metabolizing enzyme system in the liver of rats", 10(1), pp.29~36 (2002)
  9. "CYP induction-mediated drug interactions : in vitro assessment and clinical implications", 23(6), pp.1089~1116 (2006)
  10. "The effect of Korean red ginseng water extract on aging-related changes in the xenobiotic metabolizing enzyme system in the liver of rats", 14(6), pp.329~335 (2006)
  11. "Long-term supplementation of Epimedium koreanum Nakai in rats and its effect on in vitro antioxidant status with age", 16(3), pp.404~408 (2007)
  12. "Physiological changes with age by the chronic administration of Korean red ginseng in spraque-dawley rats", 13(5), pp.242~248 (2005)
  13. "Influence of ginsenoside Rh1 and F1 on human cytochrome P450 enzymes", 72(2), pp.126~131 (2006)
  14. "Protein measurement with the Folin-phenol reagent. J. Biol.Chem. 193", pp.265~275 (1951)
  15. "Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha, 4-dihydroxy derivatives", 18(10), pp.1611~1618 (2005)
  16. "The carbon monoxide-binding pigmentof liver microsomes. I. Evidence for its hemoprotein nature. J.Biol. Chem. 239", pp.2370~2378 (1964)
  17. "Separation and characterization of highly purified forms of livermicrosomal cytochrome P-450 from rats treated with polychlorinated biphenyls", pp.1365~1374 (1979)
  18. "Phase I and phase II enzyme polymorphi는 and childhood cancer", 54(6), pp.303~320 (2006)
  19. "Multiple forms of rat liver cytochrome P-450.Immunochemical evidence with antibody against cytochrome P-448. J. Biol. Chem. 251", pp.1385~1395 (1976)
  20. "Microsomal triphosphopyridinenucleotide- cytochrome C reductase of liver. J. Biol. Chem.237", pp.587~595 (1962)
  21. "Induction of phase I, II and III drug metabolism", transport by xenobiotics, 2005, pp.28, 249~268
  22. "Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutional aspect, relation to tumorigenesis, and mechanism", 7(4), pp.397~409 (2006)
  23. "Xenobiotic-metabolizing enzymes in human lung", 7(8), pp.939~948 (2006)

관련 논문AI추천

홍삼의 물추출물이 노화에 따른 흰쥐 간의 이물질대사 효소계에 미치는 영향임흥빈한국약용작물학회 · 한국약용작물학회지2006 · 제14권 제6호인삼, 한국 및 중국산 산양삼의 간 보호 효능에 관한 실험적 연구권기록, 김영진, 김호현, 박희수대한약침학회 · Journal of Pharmacopuncture2007 · 제10권 제1호Physiological Changes with Age by the ChronicAdministration of Korean Red Ginseng in Spraque-Dawley Rats임흥빈, Dong Wook Lee, Hyung Ok Sohn한국약용작물학회 · 한국약용작물학회지2005 · 제13권 제5호음양곽의 추출물이 노화에 따른 흰쥐 간의 이물질대사 효소계에 미치는 영향손형옥, 이동욱, 이영구, 임흥빈한국약용작물학회 · 한국약용작물학회지2002 · 제10권 제1호CCl4로 급성 간손상을 유도한 백서에서 人蔘葉과 莖抽出物의 간기능 개선과 항산화 작용김기영, 박성혜, 서의석, 이민경한의병리학회 · 동의생리병리학회지2004 · 제18권 제5호한약의 약물상호작용 기전과 연구방향- 독성학적인 측면을 중심으로 -김명동, 박영철, 이선동대한예방한의학회 · 대한예방한의학회지2011 · 제15권 제1호

이 간행물의 다른 논문 (11건)

토양수분함량이 묘삼의 광합성 및 근 수량에 미치는 영향김태수, 박춘근, 현동윤, 차선우, 연병열, 김충국, 이성우pp. 367-370약용식물 전시포에 발생하는 곤충의 종류와 발생시기박정규, 이동운, 추호렬pp. 371-390구기자 품종과 교배종의 부위별 심혈관관련 질환 예방 기능성 및 항산화 활성비교박원종pp. 391-397초고압 공정에 의한 복분자의 면역조절효능 비교권민철pp. 398-404고로쇠와 우산고로쇠 나무의 부위별 항암 및 면역조절능 비교Syed Abdul Qadirpp. 405-410
원문 보기