홍삼의 물추출물이 노화에 따른 흰쥐 간의 이물질대사 효소계에 미치는 영향

Abstract

The present study was designed to investigate aging-related effects on the activities of xenobiotic metabolizing enzymes of rat liver by dietary supplementation of Korean red ginseng water-extract. Rat did not show any discernible signs or the rejection symptoms, and blood GOT and GPT levels were not influenced by ginseng water extracts. Cytochrome P-450 levels, and NADPH cytochrome P450 reductase, P-450 dependent ethoxycoumarin O-deethylase, and benzphetamine N-demethylase activities were decreased with aging, however, these phase I system enzymes activities in the ginseng group of 24 months were well maintained compared with normal group. But, Levels of cytochrome b5 and NADH-cytochrome b5 reductase activities were also decreased with aging and were not found a clear difference between two groups. Glutathione- S-transferase activity, phase II enzyme system, in liver cytosols was also decreased in old ages, but the degree of decrease was higher in normal group than in giuseng supplemented group. These results indicate that long-term supplementation of red ginseng water extracts from weaning to 24 months do not show any side effects to rats, and retard age-related deteriorations of xenobiotic metabolizing enzymes activities in old ages.