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저나트륨혈증 발생과 연관되어 증상 악화를 보이는 항LGI-1항체뇌염

Anti-LGI-1 Encephalitis with Worsening Symptoms Associated with Hyponatremia

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초록

Anti-leucine-rich glioma-inactivated 1 (LGI-1) encephalitis is clinically characterized by subacute cognitive decline and frequent seizures including fasciobrachial dystonic seizures. A 67-year-old man visited the emergency department due to the recurrent episodes of seizures of 4 days duration. At the time of the visit, he showed hyponatremia at Na 121 mg/dL. His symptoms were relieved by 3% sodium chloride and water restriction. Here we report a case of anti-LGI-1 encephalitis with worsening symptoms associated with hyponatremia.

Abstract

Anti-leucine-rich glioma-inactivated 1 (LGI-1) encephalitis is clinically characterized by subacute cognitive decline and frequent seizures including fasciobrachial dystonic seizures. A 67-year-old man visited the emergency department due to the recurrent episodes of seizures of 4 days duration. At the time of the visit, he showed hyponatremia at Na 121 mg/dL. His symptoms were relieved by 3% sodium chloride and water restriction. Here we report a case of anti-LGI-1 encephalitis with worsening symptoms associated with hyponatremia.

참고문헌 (6)

  1. Dalmau J, "Antibody-mediated encephalitis", N Engl J Med, 378, pp.840~851 (2018)
  2. van Sonderen A, "Anti-LGI1 encephalitis : clinical syndrome and long-term follow-up", Neurology, 87, pp.1449~1456 (2016)
  3. Ariño H, "Anti-LGI1-associated cognitive impairment : presentation and long-term outcome", Neurology, 87, pp.759~765 (2016)
  4. Irani SR, "Morvan syndrome : clinical and serological observations in 29 cases", Ann Neurol, 72, pp.241~255 (2012)
  5. Whiles E, "Leucine-rich glioma-inactivated protein 1(LGI-1)mediated limbic encephalitis associated with syndrome of inappropriate antidiuretic hormone secretion : a case report", Oxf Med Case Reports, 2020, pp.omz136~ (2020)
  6. 김현진, "안면상완근긴장발작으로 발현한 항LGI1항체 자가면역뇌염", 대한신경과학회지, 32(1), pp.22~25 (2014), 대한신경과학회

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