Aquatic Exercise at Thermoneutral Water Temperature Enhances Antitumor Immune Responses
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초록
Despite the broad rehabilitative potential of aquatic exercises, the relationship between aquatic exercise and the immune system has not been fully elucidated to date. In particular, there are few specific and delicate immunological approaches to the effect of water temperature on immunity. Thus, we examined the effect of water temperature on immunity during aquatic exercise. The animal tumor model was adopted to examine the impact of aquatic exercise at thermoneutral temperature (TT; 29°C) on immunity compared with aquatic exercise at body temperature (BT; 36°C). Tumor-bearing mice were made to swim in TT water or in BT water for 3 wk and immune cells and their functional activity were analyzed using FACS. Tumor growth was significantly suppressed in mice that exercised in TT than in BT water. The tumor control correlated with the increased number of NK (2-fold), γδT cells (2.5-fold), NKT (2.5-fold), and cytotoxic CD8+ T cells (1.6-fold), which play a critical role in anti-tumor immune responses. Furthermore, the functional activity was dramatically improved in the TT group, showing enhanced production of IFNγ in CD8+ T cells compared with the BT group. This study demonstrates that aquatic exercise in TT water may improve protective immune responses more effectively than in BT water. Although the effects of water temperature on immune function need further verification in humans, this study suggests that water temperature in human hydrotherapy may be important for improving immune function.
Abstract
Despite the broad rehabilitative potential of aquatic exercises, the relationship between aquatic exercise and the immune system has not been fully elucidated to date. In particular, there are few specific and delicate immunological approaches to the effect of water temperature on immunity. Thus, we examined the effect of water temperature on immunity during aquatic exercise. The animal tumor model was adopted to examine the impact of aquatic exercise at thermoneutral temperature (TT; 29°C) on immunity compared with aquatic exercise at body temperature (BT; 36°C). Tumor-bearing mice were made to swim in TT water or in BT water for 3 wk and immune cells and their functional activity were analyzed using FACS. Tumor growth was significantly suppressed in mice that exercised in TT than in BT water. The tumor control correlated with the increased number of NK (2-fold), γδT cells (2.5-fold), NKT (2.5-fold), and cytotoxic CD8+ T cells (1.6-fold), which play a critical role in anti-tumor immune responses. Furthermore, the functional activity was dramatically improved in the TT group, showing enhanced production of IFNγ in CD8+ T cells compared with the BT group. This study demonstrates that aquatic exercise in TT water may improve protective immune responses more effectively than in BT water. Although the effects of water temperature on immune function need further verification in humans, this study suggests that water temperature in human hydrotherapy may be important for improving immune function.
참고문헌 (33)
- Pöyhönen T, "Effects of aquatic resistance training on neuromuscular performance in healthy women", Med Sci Sports Exerc, 34, pp.2103~2109 (2002)
- Batterham SI, "Systematic review and meta-analysis comparing land and aquatic exercise for people with hip or knee arthritis on function, mobility and other health outcomes", BMC Musculoskelet Disord, 12, pp.123~ (2011)
- Becker BE, "Aquatic therapy: scientific foundations and clinical rehabilitation applications", PM R, 1, pp.859~872 (2009)
- Holloszy JO, "Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory", J Appl Physiol, 61, pp.1656~1660 (1986)
- Brenner IK, "Immune changes in humans during cold exposure: effects of prior heating and exercise", J Appl Physiol, 87, pp.699~710 (1999)
- Cheng GJ, "Immunosuppression in mice induced by cold water stress", Brain Behav Immun, 4, pp.278~291 (1990)
- Janský L, "Immune system of cold-exposed and cold-adapted humans", Eur J Appl Physiol Occup Physiol, 72, pp.445~450 (1996)
- Kokolus KM, "Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature", Proc Natl Acad Sci U S A, 110, pp.20176~20181 (2013)
- Sundaresan G, "Certain immunological parameters in subacute cold stress", Indian J Physiol Pharmacol, 34, pp.57~60 (1990)
- Terrien J, "Behavioral thermoregulation in mammals: a review", Front Biosci (Landmark Ed), 16, pp.1428~1444 (2011)
- Karp CL, "Unstressing intemperate models: how cold stress undermines mouse modeling", J Exp Med, 209, pp.1069~1074 (2012)
- Cannon B, "Brown adipose tissue: function and physiological significance", Physiol Rev, 84, pp.277~359 (2004)
- Shephard RJ, "Cold exposure and immune function", Can J Physiol Pharmacol, 76, pp.828~836 (1998)
- Won SJ, "Thermal stresses reduce natural killer cell cytotoxicity", J Appl Physiol, 79, pp.732~737 (1995)
- Aviles H, "Effects of cold stress on spleen cell proliferation and cytokine production during chronic Toxoplasma gondii infection", Neuroimmunomodulation, 11, pp.93~102 (2004)
- Banerjee SK, "Cold stress-induced modulation of cell immunity during acute Toxoplasma gondii infection in mice", J Parasitol, 85, pp.442~447 (1999)
- Shu J, "Modulation of cellular immune responses by cold water swim stress in the rat", Dev Comp Immunol, 17, pp.357~371 (1993)
- Lee B, "Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice", Int J Chron Obstruct Pulmon Dis, 12, pp.817~827 (2017)
- Kim G, "Soluble γc receptor attenuates anti-tumor responses of CD8+ T cells in T cell immunotherapy", Int J Cancer, 143, pp.1212~1223 (2018)
- Fridman WH, "The immune contexture in human tumours: impact on clinical outcome", Nat Rev Cancer, 12, pp.298~306 (2012)
- Gober HJ, "Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells", J Exp Med, 197, pp.163~168 (2003)
- Hong C, "CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection", J Immunol, 177, pp.6747~6757 (2006)
- Hong C, "Regulation of secondary antigen-specific CD8+ T-cell responses by natural killer T cells", Cancer Res, 69, pp.4301~4308 (2009)
- Yang Q, "Antitumor activity of NK cells", Immunol Res, 36, pp.13~25 (2006)
- Nguyen KD, "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis", Nature, 480, pp.104~108 (2011)
- Padgett DA, "How stress influences the immune response", Trends Immunol, 24, pp.444~448 (2003)
- Davis MS, "Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air", Am J Vet Res, 68, pp.185~189 (2007)
- Aarstad HJ, "Stress causes reduced natural killer activity in mice", Scand J Immunol, 18, pp.461~464 (1983)
- Goundasheva D, "Changes in some parameters of the immune response in rats after cold stress", Zentralbl Veterinarmed B, 41, pp.670~674 (1994)
- Shimizu I, "Enhanced thermal avoidance in mice lacking the ATP receptor P2X3", Pain, 116, pp.96~108 (2005)
- Lee YJ, "Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells", Nat Immunol, 14, pp.1146~1154 (2013)
- Rolot M, "Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection", Nat Commun, 9, pp.4516~ (2018)
- 박희정, "Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues", Immune Network, 16(2), pp.126~133 (2016), 대한면역학회[DOI]