Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-α and Interferon-γ in Sedentary Men
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Physical activity could be considered one of the factors thataffect the immune system status and function. To find the relationbetween exercise and cytokines, we examined the possibleeffects of an 8-week endurance training program on theserum levels of cytokines, including tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in sedentarymen. A total of 30 healthy young male volunteers wererandomly divided into an endurance training group and a controlgroup. The training group followed a specific exerciseprotocol (running on a treadmill for 15∼30 min at 50∼70%maximal heart rate) for 8 weeks and the control group did notparticipate in any exercise program. Venous blood sampleswere collected from both the groups 24 h before and 24 hand 48 h after the exercise. Repeated ANOVA was used forstatistical purposes. The serum levels of TNF-α and IFN-γwere determined by ELISA. Significant (p＜0.05) andnon-significant (p＞0.05) decreases were observed in theserum levels of IFN-γ and TNF-α, respectively, after the8-week endurance training program. Our findings indicatedthat an 8-week endurance exercise may affect the serum levelsof some inflammatory cytokines, suggesting the beneficialrole of this training protocol in elderly population andpeople with certain conditions (inflammation of the vertebraeor other inflammatory diseases).
Abstract
Physical activity could be considered one of the factors thataffect the immune system status and function. To find the relationbetween exercise and cytokines, we examined the possibleeffects of an 8-week endurance training program on theserum levels of cytokines, including tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in sedentarymen. A total of 30 healthy young male volunteers wererandomly divided into an endurance training group and a controlgroup. The training group followed a specific exerciseprotocol (running on a treadmill for 15∼30 min at 50∼70%maximal heart rate) for 8 weeks and the control group did notparticipate in any exercise program. Venous blood sampleswere collected from both the groups 24 h before and 24 hand 48 h after the exercise. Repeated ANOVA was used forstatistical purposes. The serum levels of TNF-α and IFN-γwere determined by ELISA. Significant (p＜0.05) andnon-significant (p＞0.05) decreases were observed in theserum levels of IFN-γ and TNF-α, respectively, after the8-week endurance training program. Our findings indicatedthat an 8-week endurance exercise may affect the serum levelsof some inflammatory cytokines, suggesting the beneficialrole of this training protocol in elderly population andpeople with certain conditions (inflammation of the vertebraeor other inflammatory diseases).
참고문헌 (22)
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