The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living.
Abstract
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living.
참고문헌 (9)
- Kim JY, "Effects of polydeoxyribonucleotide in the treatment of pressure ulcers", J Korean Med Sci, 29(Suppl 3), pp.S222~S227 (2014)[DOI]
- Lee DW, "The effect of polydeoxyribonucleotide on ischemic rat skin flap survival", Ann Plast Surg, 75, pp.84~90 (2015)[DOI]
- Bitto A, "Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease", J Vasc Surg, 48, pp.1292~1300 (2008)[DOI]
- Altavilla D, "Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers", Cardiovasc Hematol Agents Med Chem, 7, pp.313~321 (2009)[DOI]
- Pang C, "An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing", Int Wound J, 14, pp.450~459 (2017)[DOI]
- Saltmarche AE, "Low level laser therapy for healing acute and chronic wounds: the extendicare experience", Int Wound J, 5, pp.351~360 (2008)[DOI]
- Sen CK, "Human skin wounds: a major and snowballing threat to public health and the economy", Wound Repair Regen, 17, pp.763~771 (2009)[DOI]
- Menke NB, "Impaired wound healing", Clin Dermatol, 25, pp.19~25 (2007)[DOI]
- Insausti CL, "Amniotic membrane induces epithelialization in massive posttraumatic wounds", Wound Repair Regen, 18, pp.368~377 (2010)[DOI]