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Combination treatments employing CO2 fractional lasers with polydeoxyribonucleotide injections for chronic atrophic scar in Republic of Korea: a case report

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초록

The use of ablative lasers for chronic atrophic scars poses a significant challenge, requiring extended downtime and leading to side effects, such as irregular dyspigmentation and post-laser erythema. This case report presents the synergistic treatment a chronic atrophic scar using a CO2 fractional laser alongside intradermal polydeoxyribonucleotide (PDRN) injections. A 25-year-old female received six sessions of a CO2 fractional laser treatment at 4-week intervals, coupled with intradermal PDRN injections. The scar exhibited remarkable improvement after treatment, and the patient was satisfied with the outcome. Combining a CO2 fractional laser with a PDRN injection can enhance wound healing, reduce downtime, and improve the clinical outcomes.

Abstract

The use of ablative lasers for chronic atrophic scars poses a significant challenge, requiring extended downtime and leading to side effects, such as irregular dyspigmentation and post-laser erythema. This case report presents the synergistic treatment a chronic atrophic scar using a CO2 fractional laser alongside intradermal polydeoxyribonucleotide (PDRN) injections. A 25-year-old female received six sessions of a CO2 fractional laser treatment at 4-week intervals, coupled with intradermal PDRN injections. The scar exhibited remarkable improvement after treatment, and the patient was satisfied with the outcome. Combining a CO2 fractional laser with a PDRN injection can enhance wound healing, reduce downtime, and improve the clinical outcomes.

참고문헌 (7)

  1. Nobari NN, "A systematic review of the comparison between needling(RF-needling, meso-needling, and microneedling)and ablative fractional lasers(CO2, erbium YAG)in the treatment of atrophic and hypertrophic scars", Lasers Med Sci, 38, pp.67~ (2023)
  2. Gawdat HI, "Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars", Dermatol Surg, 40, pp.601~ (2014)
  3. Galeano M, "Polydeoxyribonucleotide : a promising biological platform to accelerate impaired skin wound healing", Pharmaceuticals(Basel), 14, pp.1103~ (2021)
  4. Jeong W, "Scar prevention and enhanced wound healing induced by polydeoxyribonucleotide in a rat incisional wound-healing model", Int J Mol Sci, 18, pp.1698~ (2017)
  5. Yu M, "Polydeoxyribonucleotide improves wound healing of fractional laser resurfacing in rat model", J Cosmet Laser Ther, 19, pp.43~48 (2017)
  6. Keun Jae Ahn, "Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients", Medical Lasers, 10(2), pp.90~95 (2021), 대한의학레이저학회[DOI]
  7. Beltraminelli H, "Fractional transepidermal delivery : a histological analysis", Dermatology, 223, pp.321~324 (2011)

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