바다송사리, Oryzias dancena와 자바송사리, O. javanicus 간 잡종에 대한 비스페놀 A의 효과
Effects of Bisphenol A to interspecific hybrids between marine medaka Oryzias dancena and javanese medaka O. javanicus
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Bisphenol A (BPA) is mainly used in the production of epoxy resins and polycarbonate plastics, which is a known endocrine disruptor and acutely toxic to aquatic organisms. In this study, estrogenic effect of BPA was investigated on hybrid between Oryzias dancena and O. javanicus (ODJ). ODJ were exposed to BPA of various concentrations (eg. 2.5 mg/L, 5.0 mg/L and 10.0 mg/L) for 56 days. The growth rate, abnormality and the ratio of female and male were observed in test group and control group. As a result, the growth was 14.7 ± 2.0 mm in total length (TL) in 2.5 mg/L, 13.7 ± 2.5 mm in 5.0 mg/L, 12.8 ± 2.5 mm in 10.0 mg/L in test group while it was 18.0 ± 1.2 mm in TL in control group which was not treated with bisphenol A. The result showed that the growth decreased as the concentration of BPA increased. The abnormality rate was 13.6% in control group, 65.4% in 2.5 mg/L, 81.3% in 5.0 mg/L and 98.1% in 10.0 mg/L which showed increase in abnormality as an increase of BPA concentration. As a result of analyzing ratio of sex in the test group and control group, 6.0% was examined to be interspecific in controls, 76.9% in 2.5 mg/L and 100.0% in 5.0 mg/L and 10.0 mg/L. In conclusion, these results suggest that BPA has estrogenic effect on ODJ.
Abstract
Bisphenol A (BPA) is mainly used in the production of epoxy resins and polycarbonate plastics, which is a known endocrine disruptor and acutely toxic to aquatic organisms. In this study, estrogenic effect of BPA was investigated on hybrid between Oryzias dancena and O. javanicus (ODJ). ODJ were exposed to BPA of various concentrations (eg. 2.5 mg/L, 5.0 mg/L and 10.0 mg/L) for 56 days. The growth rate, abnormality and the ratio of female and male were observed in test group and control group. As a result, the growth was 14.7 ± 2.0 mm in total length (TL) in 2.5 mg/L, 13.7 ± 2.5 mm in 5.0 mg/L, 12.8 ± 2.5 mm in 10.0 mg/L in test group while it was 18.0 ± 1.2 mm in TL in control group which was not treated with bisphenol A. The result showed that the growth decreased as the concentration of BPA increased. The abnormality rate was 13.6% in control group, 65.4% in 2.5 mg/L, 81.3% in 5.0 mg/L and 98.1% in 10.0 mg/L which showed increase in abnormality as an increase of BPA concentration. As a result of analyzing ratio of sex in the test group and control group, 6.0% was examined to be interspecific in controls, 76.9% in 2.5 mg/L and 100.0% in 5.0 mg/L and 10.0 mg/L. In conclusion, these results suggest that BPA has estrogenic effect on ODJ.
참고문헌 (28)
- Alo, R, "Effects of the xenoestrogen bispheno A in diencephalic regions of the teleost fish Coris julis occur preferentially via distinct somatostatin receptor subtypes", Brain Res. Bull, 65, pp.267~273 (2005)
- Arukwe, A, "Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar)", Aquat. Toxicol, 49, pp.159~170 (2000)
- Brotons, J.A, "Xenoestrogens released from lacquer coatings in food cans, Environ", Health Perspectives, 103, pp.608~612 (1995)
- Estlander, T, "Occupational contact allergy to bisphenol", A. Contact Dermatitis, 40, pp.52~53 (1999)
- Gray, M.A, "Factors affecting the development of testis-ova in medaka, Oryzias latipes, exposed to octylphenol", Environmental Toxicology and Chemistry, 18, pp.1835~1842 (1999)
- Haubruge, E, "Reduced sperm counts in guppies (Poecilia reticulata) following exposure to low levels of tributyltin and bisphenol", A. Proc. R. Soc. Lond. B, 267, pp.2333~2337 (2000)
- Inoue, K, "Asian medaka fishes offer new models for studying mechanisms of seawater adaptation", Comp. Biochem. Physiol. B, 136, pp.635~645 (2003)
- Ishibashi, H, "Toxicity to early life stages and an estrogenic effect of a bisphenol A metabolite, 4-methyl-2,4-bis (4-hydroxyphenyl) pent-1-ene on the medaka (Oryzias latipes)", Life Sciences, 77, pp.2643~2655 (2005)
- Kang, I.J, "Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes)", Environ. Toxicol. Chem, 21, pp.2394~2400 (2002)
- Kim, D.S, "Gonadal sex differentiation in Misgurnus mizolepis", Korean J. Ichthyol, 2, pp.95~105 (1990)
- Kishida, M, "Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio)", Comp. Biochem. Physiol, 129, pp.261~268 (2001)
- Kwak, H.J, "Effects of nonylphenol, bisphenol A, and their mixture on the vivipaours swordtail fish (Xiphophorus helleri)", Environ. Toxicol. Chem, 20, pp.787~795 (2001)
- Labadie, P, "Alteration of steroid hormone balance in juvenile turbot (Psetta maxaxa) exposed to nonylphenol, bisphenol A, tetrabromodiphenyl ether 47, diallylphthalate, oil, and oil spiked with alkylphenols", Arch. Environ. Contam. Toxicol, 50, pp.552~561 (2006)
- Lahnsteiner, F, "Effect of bisphenol A on maturation and quality of semen and eggs in the brown trout, Salmo trutta f. fario", Aquat. Toxicol, 75, pp.213~224 (2005)
- Lindholst, C, "Estrogenics response of bisphenol A in rainbow trout (Oncorhynchus mykiss)", Aquatic Toxicol, 48, pp.87~94 (2000)
- Milligan, S.R, "Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma", General and Comparative Endocrinology, 112, pp.89~95 (1998)
- Nimrod, A.C, "Reproduction and development of Japanese medaka following an early life stage exposure to xenoestrogens", Aquatic. Toxicol, 44, pp.141~156 (1998)
- Robert, T.R, "Systematic observations on tropical Asian medakas or ricefishes of the genus Oryzias, with descriptions of four new species", Ichthyol. Res, 45, pp.213~224 (1998)
- Seki, M, "Effect of ethinylestradiol on the reproduction and induction of vitellogenin and testis-ova in medaka (Oryzias latipes)", Environmental Toxicology and Chemistry, 21, pp.1692~1698 (2002)
- Sohoni, P, "Reproductive effects of long-term exposure to bisphenol A in the fathead minnow (Pimephales promelas)", Environ. Sci. Technol, 35, pp.2917~2925 (2001)
- 송하연, "바다송사리 Oryzias dancena와 자바송사리 Oryzias javanicus 간 잡종 유도", 한국수산과학회지, 43(5), pp.462~473 (2010), 한국수산과학회
- Tabata, A, "The effect of bisphenol A and chlorinated derivatives of bisphenol A on the level of serum vitellogenin in Japanese medaka (Oryzias latipes)", Water Sci. Technol, 50, pp.125~132 (2004)
- Tabata, A, "The effect of chlorination of estrogenic chemicals on the level of serum vitellogenin of Japanese medaka (Oryzias latipes)", Water Science and Technology, 47, pp.51~57 (2003)
- TemaNord, "Chemicals with Estrogen-Like Effects", pp.35~51 (1996), Nordic Council of Ministers, Copenhagen
- Van den Belt, "Comparison of vitellogenin responses in zebrafish and rainbow trout following exposure to environmental estrogens", Ecotoxicol. Environ. Safety, 56, pp.271~281 (2003)
- Yamamoto, T, "Artificially induced sex-reversal in genotypic males of the medaka, Oryzias latipes", J. Exp. Zool, 123, pp.571~594 (1953)
- Yokota, H, "Effect of bisphenol A on the early life stage in Japanese medaka (Oryzias latipes)", Environ. Toxicol. Chem, 19, pp.1925~1930 (2000)
- Zha, J, "Acute and early life stage toxicity of industrial effulent on Japanese medaka (Oryzias latipes)", Sci. Total Environ, 357, pp.112~119 (2006)