본문 바로가기
KERD
논문KCI 등재

The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

1

조회

0

다운로드

3

인용

0

참고문헌

키워드

주제분류정형외과학

초록

Titanium (Ti) particles and ions have been investigated in recent years as important fac- tors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various da- tabases to determine the current position of Ti particles and ions role in the pathogene- sis of peri-implantitis. There are several in vitro, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implan- titis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri- implantitis with respect to foreign body reaction, cellular response, epigenetic mecha- nisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methyla- tion, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.

Abstract

Titanium (Ti) particles and ions have been investigated in recent years as important fac- tors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various da- tabases to determine the current position of Ti particles and ions role in the pathogene- sis of peri-implantitis. There are several in vitro, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implan- titis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri- implantitis with respect to foreign body reaction, cellular response, epigenetic mecha- nisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methyla- tion, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.

참고문헌 (55)

  1. Albrektsson T, "Osseointegrated dental implants", Dent Clin North Am, 30, pp.151~174 (1986)
  2. Bosshardt DD, "Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions", Periodontol 2000, 73, pp.22~40 (2017)[DOI]
  3. Goo CL, "Beyond osseointegration : Dealing with late dental implant complications", J Oral Implantol, 46, pp.602~611 (2020)[DOI]
  4. Ramanauskaite A, "The efficacy of supportive peri-implant therapies in preventing peri-implantitis and implant loss : A systematic review of the literature", J Oral Maxillofac Res, 7, pp.e12~ (2016)[DOI]
  5. Renvert S, "Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations", J Clin Periodontol, 45(Suppl 20), pp.S278~S285 (2018)[DOI]
  6. Lang NP, "Periimplant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology", J Clin Periodontol, 38(Suppl 11), pp.178~181 (2011)[DOI]
  7. Canullo L, "International brainstorming meeting on etiologic and risk factors of peri-implantitis, montegrotto (Padua, Italy), August 2014", Int J Oral Maxillofac Implants, 30, pp.1093~1104 (2015)[DOI]
  8. Fretwurst T, "Is metal particle release associated with peri-implant bone destruction? An emerging concept", J Dent Res, 97, pp.259~265 (2018)[DOI]
  9. Albrektsson T, "“Peri-Implantitis”: A complication of a foreign body or a man-made “Disease”. Facts and fiction", Clin Implant Dent Relat Res, 18, pp.840~849 (2016)[DOI]
  10. Bressan E, "Metal nanoparticles released from dental implant surfaces: Potential contribution to chronic inflammation and peri-implant bone loss", Materials(Basel), 12, pp.2036~ (2019)[DOI]
  11. Nelson K, "Distribution and chemical speciation of exogenous micro-and nanoparticles in inflamed soft tissue adjacent to titanium and ceramic dental implants", Anal Chem, 92, pp.14432~14443 (2020)[DOI]
  12. Mombelli A, "What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review", Clin Oral Implants Res, 29(Suppl 18), pp.37~53 (2018)[DOI]
  13. Romanos GE, "Titanium wear of dental implants from placement, under loading and maintenance protocols", Int J Mol Sci, 22, pp.1067~ (2021)[DOI]
  14. Silva GAF, "Effect of macrogeometry and bone type on insertion torque, primary stability, surface topography damage and titanium release of dental implants during surgical insertion into artificial bone", J Mech Behav Biomed Mater, 119, pp.104515~ (2021)[DOI]
  15. Kunrath MF, "Innovative surfaces and alloys for dental implants : What about biointerface-safety concerns?", Dent Mater, 37, pp.1447~1462 (2021)[DOI]
  16. Soler MD, "Titanium corrosion in peri-implantitis", Materials(Basel), 13, pp.5488~ (2020)[DOI]
  17. Schwarz F, "Combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination : a 7-year follow-up observation", J Clin Periodontol, 44, pp.337~342 (2017)[DOI]
  18. Heitz-Mayfield LJ, "The therapy of peri-implantitis : a systematic review", Int J Oral Maxillofac Implants, 29(Suppl), pp.325~345 (2014)[DOI]
  19. Noronha Oliveira M, "Can degradation products released from dental implants affect peri-implant tissues?", J Periodontal Res, 53, pp.1~11 (2018)[DOI]
  20. Wang X, "Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model", J Periodontal Res, 54, pp.329~338 (2019)[DOI]
  21. Asa’ad F, "Role of epigenetics in alveolar bone resorption and regeneration around periodontal and peri-implant tissues", Eur J Oral Sci, 127, pp.477~493 (2019)[DOI]
  22. Suárez-López Del Amo F, "Dental implants-associated release of titanium particles : A systematic review", Clin Oral Implants Res, 29, pp.1085~1100 (2018)[DOI]
  23. Ramanauskaite A, "Surgical non-regenerative treatments for peri-implantitis : A systematic review", J Oral Maxillofac Res, 7, pp.e14~ (2016)[DOI]
  24. Renvert S, "Clinical approaches to treat peri-implant mucositis and peri-implantitis", Periodontol 2000, 68, pp.369~404 (2015)[DOI]
  25. Farronato D, "Decontamination of customized laser-microtextured titanium abutments : A comparative in vitro study of different cleaning procedures", Int J Periodontics Restorative Dent, 38, pp.e87~e95 (2018)[DOI]
  26. Barrak FN, "Particle release from implantoplasty of dental implants and impact on cells", Int J Implant Dent, 6, pp.50~ (2020)[DOI]
  27. Wu X, "Characteristics of particles and debris released after implantoplasty: A comparative study", Materials (Basel), 15, pp.602~ (2022)[DOI]
  28. Albrektsson T, "Crestal bone loss and oral implants", Clin Implant Dent Relat Res, 14, pp.783~791 (2012)[DOI]
  29. Toledano-Serrabona J, "Ion release and local effects of titanium metal particles from dental implants : An experimental study in rats", J Periodontol (2022)[DOI]
  30. Rakic M, "Study on the immunopathological effect of titanium particles in peri-implantitis granulation tissue : A case-control study", Clin Oral Implants Res, 33, pp.656~666 (2022)[DOI]
  31. Berryman Z, "Titanium particles : An emerging risk factor for peri-implant bone loss", Saudi Dent J, 32, pp.283~292 (2020)[DOI]
  32. Barrak F, "Particle release from dental implants immediately after placement-An ex vivo comparison of different implant systems", Dent Mater, 38, pp.1004~1014 (2022)[DOI]
  33. Suárez-López Del Amo F, "Titanium activates the DNA damage response pathway in oral epithelial cells : A pilot study", Int J Oral Maxillofac Implants, 32, pp.1413~1420 (2017)[DOI]
  34. Kumazawa R, "Effects of Ti ions and particles on neutrophil function and morphology", Biomaterials, 23, pp.3757~3764 (2002)[DOI]
  35. Wachi T, "Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption", Toxicology, 327, pp.1~9 (2015)[DOI]
  36. Pettersson M, "Titanium ions form particles that activate and execute interleukin-1β release from lipopolysaccharide-primed macrophages", J Periodontal Res, 52, pp.21~32 (2017)[DOI]
  37. Eger M, "Scaling of titanium implants entrains inflammation-induced osteolysis", Sci Rep, 7, pp.39612~ (2017)[DOI]
  38. Kunrath MF, "Osteoblastic cell behavior and early bacterial adhesion on macro-, micro-, and nanostructured titanium surfaces for biomedical implant applications", Int J Oral Maxillofac Implants, 35, pp.773~781 (2020)[DOI]
  39. Kunrath MF, "Influence of saliva interaction on surface properties manufactured for rapid osseointegration in dental implants", Biofouling, 37, pp.757~766 (2021)[DOI]
  40. Revathi A, "Degradation mechanisms and future challenges of titanium and its alloys for dental implant applications in oral environment", Mater Sci Eng C Mater Biol Appl, 76, pp.1354~1368 (2017)[DOI]
  41. Kunrath MF, "Superhydrophilic nanotextured surfaces for dental implants: Influence of early saliva contamination and wet storage", Nanomaterials(Basel), 12, pp.2603~ (2022)[DOI]
  42. Schwarz F, "Surgical therapy of advanced ligature-induced peri-implantitis defects : cone-beam computed tomographic and histological analysis", J Clin Periodontol, 38, pp.939~949 (2011)[DOI]
  43. Olmedo DG, "Exfoliative cytology and titanium dental implants : a pilot study", J Periodontol, 84, pp.78~83 (2013)[DOI]
  44. Fretwurst T, "Metal elements in tissue with dental peri-implantitis : a pilot study", Clin Oral Implants Res, 27, pp.1178~1186 (2016)[DOI]
  45. Wilson TG, "Foreign bodies associated with peri-implantitis human biopsies", J Periodontol, 86, pp.9~15 (2015)[DOI]
  46. Kunrath MF, "Metallic-nanoparticle release systems for biomedical implant surfaces : effectiveness and safety", Nanotoxicology, 15, pp.721~739 (2021)[DOI]
  47. Bird A, "DNA methylation patterns and epigenetic memory", Genes Dev, 16, pp.6~21 (2002)[DOI]
  48. Adcock IM, "Epigenetic regulation of airway inflammation", Curr Opin Immunol, 19, pp.694~700 (2007)[DOI]
  49. Lod S, "The influence of epigenetics in relation to oral health", Int J Dent Hyg, 12, pp.48~54 (2014)[DOI]
  50. Daubert DM, "Association of global DNA methylation to titanium and peri-implantitis : A case-control study", JDR Clin Trans Res, 4, pp.284~291 (2019)[DOI]
  51. Khouly I, "Global DNA methylation in dental implant failure due to peri-implantitis : An exploratory clinical pilot study", Int J Environ Res Public Health, 19, pp.1020~ (2022)[DOI]
  52. Ichioka Y, "Epigenetic changes of osteoblasts in response to titanium surface characteristics", J Biomed Mater Res A, 109, pp.170~180 (2021)[DOI]
  53. Lindhe J, "Peri-implant diseases : Consensus report of the sixth European workshop on periodontology", J Clin Periodontol, 35, pp.282~285 (2008)[DOI]
  54. Souza JGS, "Titanium particles and ions favor dysbiosis in oral biofilms", J Periodontal Res, 55, pp.258~266 (2020)[DOI]
  55. Daubert D, "Titanium as a modifier of the peri-implant microbiome structure", Clin Implant Dent Relat Res, 20, pp.945~953 (2018)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (6건)