무모생쥐를 이용한 Disk 형태(DTS) 미세침롤러의 피부안정성에 관한 연구
The Stability of the Disk-type Microneedle in Skh-hairless-1 (Albino) Mice
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Background: The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue. Objective: The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and directly compare them with conventional Microneedle Therapy System (MTSⓇ, Clinical Resolution Lab, California,USA). Method: We used 3 sizes of manual and electric Diskmicroneedle Therapy System (DTS; 0.25 mm, 1.0 mm and 1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy System (MTSⓇ). To evaluate the stability, visual inspection and biopsy were conducted. Result: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin. Conclusion: Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully.
Abstract
Background: The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue. Objective: The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and directly compare them with conventional Microneedle Therapy System (MTSⓇ, Clinical Resolution Lab, California,USA). Method: We used 3 sizes of manual and electric Diskmicroneedle Therapy System (DTS; 0.25 mm, 1.0 mm and 1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy System (MTSⓇ). To evaluate the stability, visual inspection and biopsy were conducted. Result: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin. Conclusion: Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully.
참고문헌 (14)
- Higo N, "Recent trend of transdermal drug delivery system development", Yakugaku Zasshi, 127, pp.655~62 (2007)
- Henry S, "McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery", J Pharm Sci, 87, pp.922~25 (1998)
- Vandervoort J, "Microneedles for transdermal drug delivery: a minireview", Front Biosce, 13, pp.1711~5 (2008)
- Yoon J, "Enhancement of optical skin clearing efficacy using a microneedle roller", J Biomed Opt, 13 (2008)
- Sivamani RK, "Microneedles and transdermal applications", Expert Opin Derug Deliv, 4, pp.19~25 (2007)
- Verma DD, "Invasomes-novel topical carriers for enhanced topical delivery: characterization and skin penetration properties", 박사, pp.2002
- Verma DD, "Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study", Eur J Pharm Biopharm, 55, pp.271~7 (2003)
- Vandervoort J, "Microneedles for transdermal drug delivery: a minireview", Front Biosci, 13, pp.1711~5 (2008)
- Prausnitz MR, "Microneedles for transdermal drug delivery", Adv Drug Deliv Rev, 56, pp.581~7 (2004)
- Al-Qallaf B, "Optimizing microneedle arrays to increase skin permeability for transdermal drug delivery", Ann N Y Acad Sci, 1161, pp.83~94 (2009)
- Badran MM, "Skin penetration enhancement by a microneedle device (DermarollerⓇ) in vitro: dependency on needle size and applied formulation", J Eur Pharm Sci, 36, pp.511~3 (2009)
- Wang PM, "Precise microinjection into skin using hollow microneedles", J Invest Dermatol, 126, pp.1080~7 (2006)
- Gardenierss HJGE, "Silicon micromachined hollow microneedles for transdermal liquid transport", J Microelectromech Sys, 12, pp.855~62 (2003)
- Chabri F, "Microfabricated silicon microneedles for nonviral cutaneous gene delivery", Br J Dermatol, 150, pp.869~77 (2004)