Remedy effects of dandelion and milk thistle on fatty liver hemorrhagic syndrome in laying hens
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Fatty liver hemorrhagic syndrome (FLHS) is a metabolic disorder found in caged layer hens and causes reduced egg production and sudden death. Dandelion (Taraxacum coreanum , TC) and milk thistle (Cirsium japonicum var. ussuriense , CJ) are well known wild herbs inhabiting Korean penin-sula and presenting antioxidative effects. This study investigated alleviate effects of these herbal mix-ture (6:4, w/w) composed of dried powder of TC and CJ against fatty liver in laying hens. The herbs mixture 5.0, 10.0, 20.0 or 40.0 g/kg feed was provided via feed admixture for 3 weeks to laying hens having FLHS. FLHS was induced by intramuscular injection of β-estradiol (2 mg/kg bw) 2 times per week for 3 weeks and supply with high caloric feed. Egg production rate was reduced from 76.2% at pre-treatment to 49.4% at 1 week and further decreased according to β-estradiol treatment. Incre-ment of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (T-Chol) and total bilirubin (T-Bil) and decrement of serum superoxide dismutase (SOD) and gluta-thione peroxidase (GPX) with fatty liver were found by the treatment of β-estradiol. Supplementation of TC and CJ mixture via feed admixture recovered the reduction of egg production and attenuated serological changes and gross and pathological lesions of fatty liver with the best amelioration effects at 5 and 10 g TC and CJ mixture per kg feed. In conclusion, TC and CJ mixture attenuates FLHS by means of antioxidative effects. Further mechanistic study is required to explain TC and CJ’s ameliora-tion effects against FLHS in laying hens.
Abstract
Fatty liver hemorrhagic syndrome (FLHS) is a metabolic disorder found in caged layer hens and causes reduced egg production and sudden death. Dandelion (Taraxacum coreanum , TC) and milk thistle (Cirsium japonicum var. ussuriense , CJ) are well known wild herbs inhabiting Korean penin-sula and presenting antioxidative effects. This study investigated alleviate effects of these herbal mix-ture (6:4, w/w) composed of dried powder of TC and CJ against fatty liver in laying hens. The herbs mixture 5.0, 10.0, 20.0 or 40.0 g/kg feed was provided via feed admixture for 3 weeks to laying hens having FLHS. FLHS was induced by intramuscular injection of β-estradiol (2 mg/kg bw) 2 times per week for 3 weeks and supply with high caloric feed. Egg production rate was reduced from 76.2% at pre-treatment to 49.4% at 1 week and further decreased according to β-estradiol treatment. Incre-ment of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (T-Chol) and total bilirubin (T-Bil) and decrement of serum superoxide dismutase (SOD) and gluta-thione peroxidase (GPX) with fatty liver were found by the treatment of β-estradiol. Supplementation of TC and CJ mixture via feed admixture recovered the reduction of egg production and attenuated serological changes and gross and pathological lesions of fatty liver with the best amelioration effects at 5 and 10 g TC and CJ mixture per kg feed. In conclusion, TC and CJ mixture attenuates FLHS by means of antioxidative effects. Further mechanistic study is required to explain TC and CJ’s ameliora-tion effects against FLHS in laying hens.
참고문헌 (38)
- Banerjee D, "Biosynthesis of high-density lipoprotein by chicken liver : conjugation of nascent lipids with apoprotein A1", J Cell Biol, 99, pp.1917~1926 (1984)
- Belous AR, "Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation", Cancer Res, 67, pp.812~817 (2007)
- Butler EJ, "Fatty liver diseases in the domestic fowl-A review", Avian Pathol, 5, pp.1~14 (1976)
- 정민주, "흰민들레(Taraxacum coreanum) 추출물이 급성 수은 중독된 생쥐의 간에 미치는 효과", Applied Microscopy, 38(1), pp.1~10 (2008), 한국현미경학회
- 최지명, "흰민들레(Taraxacum coreanum) 활성획분인 Ethylacetate Fraction의 Peroxynitrite에 대한 산화적 스트레스 개선 효과", 대한암예방학회지, 17(3), pp.251~256 (2012), 대한암예방학회
- "Fatty liver hemorrhagic syndrome in poultry. MSD veterinary manual" (2019)[URL]
- Haghighi-Rad F, "The relationship of plasma estradiol and progesterone levels to the fatty liver hemorrhagic syndrome in laying hens", Poultry Sci, 60, pp.2278~2283 (1981)
- Han CK, "Effect of dietary lipids on liver, serum and egg yolk cholesterol contents of laying hens", Asian J Appl Sci, 6, pp.243~248 (1993)
- Hermier D, "Lipoprotein metabolism and fattening in poultry", J Nutr, 127, pp.805S~808S (1997)[DOI]
- "Management guide: Hy-Line brown commercial layers-Australia" (2018)[URL]
- Kang MJ, "Current trends of research and biological activities of dandelion", Food Ind Nutr, 6, pp.60~67 (2001)
- "Portal for information of food safety" (2016)[URL]
- Kurtoglu V, "Effect of probiotic supplementation on laying hen diets on yield performance and serum and egg yolk cholesterol", Food Addit Contam, 21, pp.817~623 (2004)
- Lee BK, "Changes in hepatic lipid parameters and hepatic messenger ribonucleic acid expression following estradiol administration in laying hens (Gallus domesticus)", Poultry Sci, 89, pp.2660~2667 (2010)
- 이희경, "엉겅퀴 추출물의 항상화성, 항돌연변이원성 및 항암활성 효과", 한국약용작물학회지, 11(1), pp.58~61 (2003), 한국약용작물학회
- Leeson S, "Poultry Metabolic Disorders and Mycotoxins", pp.55~68 (1995), University Books
- McGill MR, "The past and present of serum aminotrasferases and the future of liver injury biomarkers", Excli J, 15, pp.817~828 (2016)
- Meijering A, "Fatty liver syndrome in laying hens-An attempt to review", World’s Poult Sci J, 35, pp.79~94 (1979)
- 목지예, "엉겅퀴(Cirsium japonicum var. ussuriense) 부위별 추출물의 항산화 및 항염증 효과", 대한본초학회지, 26(4), pp.39~47 (2011), 대한본초학회
- "The fatty liver hemorrhagic syndrome (FLHS). South Dakota Poultry Field Day Proceedings and Research Reports Paper 3" (1975)[URL]
- Nilsen J, "Estradiol and neurodegenerative oxidative stress", Front Neuroendocrinol, 29, pp.463~475 (2008)
- Packard CJ, "Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects", J Clin Invest, 74, pp.2178~2192 (1984)
- Park JC, "Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats", Phytother Res, 18, pp.19~24 (2004)
- 박지영, "D-Galactosamine으로 유발된 간손상에 대한 민들레 열수추출물의 예방효과", 한국식품영양과학회지, 37(2), pp.177~183 (2008), 한국식품영양과학회
- Phaniendra A, "Free radicals : properties, sources, targets, and their implication in various diseases", Indian J Clin Biochem, 30, pp.11~26 (2015)
- Polin D, "Role of estrogen as a cause of fatty liver hemorrhagic syndrome", J Nutr, 107, pp.873~886 (1977)
- Roland DA, "Calcium and its relationship to excess feed consumption, body weight, egg size, fat deposition, shell quality, and fatty liver hemorrhage syndrome", Poultry Sci, 64, pp.2341~2350 (1985)
- Sato K, "Changes in peroxisome proliferator activated receptor gamma gene expression of chicken abdominal adipose tissue with different age, sex and genotype", Anim Sci J, 80, pp.322~327 (2009)
- Schütz K, "Taraxacum－A review on its phytochemical and pharmacological profile", J Ethnopharmacol, 107, pp.313~323 (2006)
- Occurrence and control of fatty liver haemorrhagic syndrome(FLHS)in caged hens, "Shini S", AECL, ~, pp.AECL Publication No UQ-105A (2009)
- Silva PRL, "Blood serum components and serum protein test of hybro-PG broilers of different ages", Brazilian J Poultry Sci, 9, pp.229~232 (2007)
- Simonsen HB, "Battery cages as the cause of environmental and behavioural dependent diseases", Nord Vet Med, 30, pp.241~252 (1978)
- Squires EJ, "Aetiology of fatty liver syndrome in laying hens", Br Vet J, 144, pp.602~609 (1988)
- Walsh BW, "Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins", N Engl J Med, 325, pp.1196~1204 (1991)
- Walzem RL, "Fatty liver hemorrhagic syndrome in hens overfed a purified diet. Selected enzyme activities and liver histology in relation to liver hemorrhage and reproductive performance", Poultry Sci, 72, pp.1479~1491 (1993)
- Whitehead CC, "Nutritional and metabolic aspects of fatty liver disease in poultry", Tijdschr Diergeneeskd, 104, pp.S150~S157 (1979)
- Williams CA, "Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale", Phytochem, 42, pp.121~127 (1996)
- X.T. Zou, "Effects of Dietary Dihydropyridine Supplementation on Laying Performance and Fat Metabolism of Laying Hens", Animal Bioscience, 20(10), pp.1606~1611 (2007), 아세아·태평양축산학회