A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase
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Objective: To investigate the relationship between reduced glutathione (GSH), a key molecule of the antioxidant defense system in the blood, and glutathione reductase (GR), which reduces oxidized glutathione (glutathione disulfide [GSSG]) to GSH and maintains the redox balance, with the prevalence of Alzheimer’s dementia and cognitive decline. Methods: In all, 20 participants with Alzheimer’s dementia who completed the third follow-up clinical evaluation over 6 years were selected, and 20 participants with normal cognition were selected after age and sex matching. The GSH and GR concentrations were the independent variables. Clinical diagnosis and neurocognitive test scores were the dependent variables indicating cognitive status. Results: The higher the level of GR, the greater the possibility of having normal cognition than of developing Alzheimer’s dementia. Additionally, the higher the level of GR, the higher the neurocognitive test scores. However, this association was not significant for GSH. After 6 years, the conversion rate from normal cognition to cognitive impairment was significantly higher in the lower 50th percentile of the GR group than in the upper 50th percentile. Conclusion: The higher the GR, the lower the prevalence of Alzheimer’s dementia and incidence of cognitive impairment and the higher the cognitive test scores. Therefore, GR is a potential protective biomarker against Alzheimer’s dementia and cognitive decline.
Abstract
Objective: To investigate the relationship between reduced glutathione (GSH), a key molecule of the antioxidant defense system in the blood, and glutathione reductase (GR), which reduces oxidized glutathione (glutathione disulfide [GSSG]) to GSH and maintains the redox balance, with the prevalence of Alzheimer’s dementia and cognitive decline. Methods: In all, 20 participants with Alzheimer’s dementia who completed the third follow-up clinical evaluation over 6 years were selected, and 20 participants with normal cognition were selected after age and sex matching. The GSH and GR concentrations were the independent variables. Clinical diagnosis and neurocognitive test scores were the dependent variables indicating cognitive status. Results: The higher the level of GR, the greater the possibility of having normal cognition than of developing Alzheimer’s dementia. Additionally, the higher the level of GR, the higher the neurocognitive test scores. However, this association was not significant for GSH. After 6 years, the conversion rate from normal cognition to cognitive impairment was significantly higher in the lower 50th percentile of the GR group than in the upper 50th percentile. Conclusion: The higher the GR, the lower the prevalence of Alzheimer’s dementia and incidence of cognitive impairment and the higher the cognitive test scores. Therefore, GR is a potential protective biomarker against Alzheimer’s dementia and cognitive decline.
참고문헌 (38)
- Eratne D, "Alzheimer’s disease : Clinical update on epidemiology, pathophysiology and diagnosis", Australas Psychiatry, 26, pp.347~357 (2018)
- Mandal PK, "Cognitive improvement with glutathione supplement in Alzheimer’s disease : A way forward", J Alzheimers Dis, 68, pp.531~535 (2019)
- Nestor PJ, "Advances in the early detection of Alzheimer’s disease", Nat Med, 10(Suppl), pp.S34~S41 (2004)
- Butterfield DA, "Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease", Nat Rev Neurosci, 20, pp.148~160 (2019)
- Martínez de Toda I, "Altered redox state in whole blood cells from patients with mild cognitive impairment and Alzheimer’s disease", J Alzheimers Dis, 71, pp.153~163 (2019)
- Nunomura A, "Oxidative damage is the earliest event in Alzheimer disease", J Neuropathol Exp Neurol, 60, pp.759~767 (2001)
- Cheignon C, "Oxidative stress and the amyloid beta peptide in Alzheimer’s disease", Redox Biol, 14, pp.450~464 (2018)
- Goschorska M, "Influence of acetylcholinesterase inhibitors used in Alzheimer’s disease treatment on the activity of antioxidant enzymes and the concentration of glutathione in THP-1 macrophages under fluoride-induced oxidative stress", Int J Environ Res Public Health, 16, pp.10~ (2018)
- Chen JJ, "Altered central and blood glutathione in Alzheimer’s disease and mild cognitive impairment : A metaanalysis", Alzheimers Res Ther, 14, pp.23~ (2022)
- Charisis S, "Plasma GSH levels and Alzheimer’s disease. A prospective approach. : Results from the HELIAD study", Free Radic Biol Med, 162, pp.274~282 (2021)
- Rani P, "Study on analysis of peripheral biomarkers for Alzheimer’s disease diagnosis", Front Neurol, 8, pp.328~ (2017)
- Yuan L, "Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China", Nutrition, 32, pp.193~198 (2016)
- Aybek H, "Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer’s disease in Denizli, Turkey", Clin Biochem, 40, pp.172~176 (2007)
- Ji Won Han, "Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia", PSYCHIATRY INVESTIGATION, 15(8), pp.767~774 (2018), 대한신경정신의학회[DOI]
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K) : Clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.P47~P53 (2002)
- Bell CC, "DSM-IV : Diagnostic and statistical manual of mental disorders", JAMA, 272, pp.828~829 (1994)
- Byeon G, "Dual Sensory impairment and cognitive impairment in the Korean longitudinal elderly cohort", Neurology, 96, pp.e2284~e2295 (2021)
- Hughes CP, "A new clinical scale for the staging of dementia", Br J Psychiatry, 140, pp.566~572 (1982)
- McKhann G, "Clinical diagnosis of Alzheimer’s disease : Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
- Román GC, "Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop", Neurology, 43, pp.250~260 (1993)
- Petersen RC, "Mild cognitive impairment as a diagnostic entity", J Intern Med, 256, pp.183~194 (2004)
- Miller MD, "Rating chronic medical illness burden in geropsychiatric practice and research : application of the Cumulative Illness Rating Scale", Psychiatry Res, 41, pp.237~248 (1992)
- Tae Hui Kim, "Korean Version of Mini Mental Status Examination for Dementia Screening and Its Short Form", PSYCHIATRY INVESTIGATION, 7(2), pp.102~108 (2010), 대한신경정신의학회
- Lee DY, "A normative study of the CERAD neuropsychological assessment battery in the Korean elderly", J Int Neuropsychol Soc, 10, pp.72~81 (2004)
- Seo EH, "Total scores of the CERAD neuropsychological assessment battery : Validation for mild cognitive impairment and dementia patients with diverse etiologies", Am J Geriatr Psychiatry, 18, pp.801~809 (2010)
- "Glutathione ELISA Kit (OKEH02622)"[URL]
- "ELISA Kit for Glutathione Reductase (GR)"[URL]
- Cenini G, "Oxidative stress in neurodegenerative diseases : From a mitochondrial point of view", Oxid Med Cell Longev, 2019, pp.2105607~ (2019)
- Bermejo P, "Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer’s disease from Mild Cognitive Impairment", Free Radic Res, 42, pp.162~170 (2008)
- Torres LL, "Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer’s disease", J Alzheimers Dis, 26, pp.59~68 (2011)
- Pradier C, "The mini mental state examination at the time of Alzheimer’s disease and related disorders diagnosis, according to age, education, gender and place of residence : A cross-sectional study among the French National Alzheimer database", PLoS One, 9, pp.e103630~ (2014)
- Liu H, "Gender differences in glutathione metabolism in Alzheimer’s disease", J Neurosci Res, 79, pp.861~867 (2005)
- Calamia M, "Scoring higher the second time around : Meta-analyses of practice effects in neuropsychological assessment", Clin Neuropsychol, 26, pp.543~570 (2012)
- Woltjer RL, "Role of glutathione in intracellular amyloid-alpha precursor protein", carboxy-terminal fragment aggregation and associated cytotoxicity, 2005, pp.93, 1047~1056
- Saharan S, "The emerging role of glutathione in Alzheimer’s disease", J Alzheimers Dis, 40, pp.519~529 (2014)
- Jack CR Jr, "Cerebral amyloid PET imaging in Alzheimer’s disease", Acta Neuropathol, 126, pp.643~657 (2013)
- Pocernich CB, "Elevation of glutathione as a therapeutic strategy in Alzheimer disease", Biochim Biophys Acta, 1822, pp.625~630 (2012)
- Shim YS, "Clinicopathologic study of Alzheimer’s disease : Alzheimer mimics", J Alzheimers Dis, 35, pp.799~811 (2013)
