The Application for Forensic Scientific Interpretation of Ketone Bodies Concentration as Ketoacidosis Indicators in Postmortem Blood
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Acetone and BHB should be considered disease indicators for the postmortem determination of alcoholic ketoacidosis or diabetic. The acetone and β-hydroxybutylate (BHB) as ketone bodies were analyzed in postmortem blood of 118 the fatal cases and 16 normal blood in order to diagnose an alcoholic and diabetic ketoacidosis. In the normal control group, the concentration ranged from < 10 μg/mL for acetone and 8.1~ 31.6 μg/mL for BHB. In the autopsy control group, the concentration ranged from < 10~24.6 μg/mL for acetone and 19.1~134.9 μg/mL for BHB. In chronic alcoholic death group (AD), the concentration ranged < 10~405.3 μg/mL for acetone and 20.9~1,466.8 μg/mL for BHB. In diabetic death group (DD), two cases showed high concentrations of both acetone and BHB, but the remaining two cases showed low concentrations of both acetone and BHB. In chronic alcoholic and diabetic death group (ADD), 2 cases showed a high concentration of BHB, but the remaining 2 cases showed a low concentration of BHB. All of the chronic alcoholism and diabetes groups were not shown high concentration of both acetone and BHB. However, if the BHB concentration was very high (> 200 μg/mL), it could be pathologically significant.
Abstract
Acetone and BHB should be considered disease indicators for the postmortem determination of alcoholic ketoacidosis or diabetic. The acetone and β-hydroxybutylate (BHB) as ketone bodies were analyzed in postmortem blood of 118 the fatal cases and 16 normal blood in order to diagnose an alcoholic and diabetic ketoacidosis. In the normal control group, the concentration ranged from < 10 μg/mL for acetone and 8.1~ 31.6 μg/mL for BHB. In the autopsy control group, the concentration ranged from < 10~24.6 μg/mL for acetone and 19.1~134.9 μg/mL for BHB. In chronic alcoholic death group (AD), the concentration ranged < 10~405.3 μg/mL for acetone and 20.9~1,466.8 μg/mL for BHB. In diabetic death group (DD), two cases showed high concentrations of both acetone and BHB, but the remaining two cases showed low concentrations of both acetone and BHB. In chronic alcoholic and diabetic death group (ADD), 2 cases showed a high concentration of BHB, but the remaining 2 cases showed a low concentration of BHB. All of the chronic alcoholism and diabetes groups were not shown high concentration of both acetone and BHB. However, if the BHB concentration was very high (> 200 μg/mL), it could be pathologically significant.
참고문헌 (16)
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