만성 알코올중독에 대한 사후 에틸글루쿠로나이드와 베타-히드록시부틸레이트 분석의 2증례 보고
Two Cases of the Postmortem Testing of Ethyl Glucuronide and Beta-hydroxybutyrate for Chronic Alcoholism
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To determine chronic alcoholism (or alcohol abuse) in postmortem cases, investigating the evidence in incident (or medical) reports is important, but it may not be certain. The indicator of alcohol abuse over long time periods was analyzed from hair as ethyl glucuronide (EtG). Beta-hydroxybutyrate (BHB) was analyzed from blood as a representative indicator of ketosis. Moreover, the blood was analyzed for ethanol (ethyl alcohol, EtOH) and EtG before death to determine drinking. Case 1 had chronic alcoholism and a history of diabetic disease. EtG concentration was 1,244 pg/mg in hair, and BHB in the blood was 276 mg/L. EtOH was less than 0.010% in the blood, however EtG was 0.38 mg/ L as drinking positive. Case 2 had a habit of drinking well, with EtG in hair of 54 pg/mg, BHB in the blood of 371 mg/L, EtOH of < 0.010%, and EtG of 0.81 mg/L. Although the EtOH was not detected in the blood, it was evaluated that alcohol was consumed before death, due to the EtG detected. In conclusion, forensic information from simultaneous analysis of EtG and BHB in biological samples (hair or blood) could be more cause of death effective assistant in chronic alcoholism (or alcohol abuse).
Abstract
To determine chronic alcoholism (or alcohol abuse) in postmortem cases, investigating the evidence in incident (or medical) reports is important, but it may not be certain. The indicator of alcohol abuse over long time periods was analyzed from hair as ethyl glucuronide (EtG). Beta-hydroxybutyrate (BHB) was analyzed from blood as a representative indicator of ketosis. Moreover, the blood was analyzed for ethanol (ethyl alcohol, EtOH) and EtG before death to determine drinking. Case 1 had chronic alcoholism and a history of diabetic disease. EtG concentration was 1,244 pg/mg in hair, and BHB in the blood was 276 mg/L. EtOH was less than 0.010% in the blood, however EtG was 0.38 mg/ L as drinking positive. Case 2 had a habit of drinking well, with EtG in hair of 54 pg/mg, BHB in the blood of 371 mg/L, EtOH of < 0.010%, and EtG of 0.81 mg/L. Although the EtOH was not detected in the blood, it was evaluated that alcohol was consumed before death, due to the EtG detected. In conclusion, forensic information from simultaneous analysis of EtG and BHB in biological samples (hair or blood) could be more cause of death effective assistant in chronic alcoholism (or alcohol abuse).
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