새로 진단된 제1형 및 제2형 당뇨병 환자에서 말초신경이상
Peripheral Nerve Abnormalities in Patients with Newly Diagnosed Type I and II Diabetes Mellitus
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Background: Early detection of neuropathy may prevent further progression of this complication in the diabetic patients. The purpose of this study was to evaluate the prevalence of early neuropathic complication in patients with newlydiagnosed type 1 and type 2 diabetes. Methods: Nerve conduction studies (median, ulnar, posterior tibial, peroneal, andsural nerves) were performed for 49 type 1 (27 males, mean 14.1±7.5 years) and 40 type 2 (27 males, 42.0±14.1 years)diabetic patients at onset of diabetes. Children with age at onset under 4 years and adults over 55 years were excludedto eliminate the aging effect and the influence of obstructive arteriosclerosis. Neuropathy was defined as abnormal nerveconduction findings in two or more nerves including the sural nerve. Results: Mean HbA1c level was 12.6±3.3% fortype 1 and 10.5±2.9% for type 2 diabetes. The prevalence of neuropathy was 12.2% for type 1, and 35.0% for type2 diabetes, respectively. There were significant trends in the prevalence of neuropathy with increasing age (p<0.05). The effect of the mean level of glycosylated hemoglobin on the prevalence of polyneuropathy at onset of diabetes wasborderline (p=0.0532). Neither sex of the patients nor the type of diabetes affected the neurophysiologic abnormalitiesat the diagnosis. Conclusions: Even in a population with diabetes at the diagnosis, the prevalence of subclinical neuropathywas not low. Neuropathy has been significantly associated with increasing age indicating the possibility of longerduration of undetected diabetes among them, especially in type 2 diabetes. (Korean J Clin Neurophysiol 2014;16:8-14)
Abstract
Background: Early detection of neuropathy may prevent further progression of this complication in the diabetic patients. The purpose of this study was to evaluate the prevalence of early neuropathic complication in patients with newlydiagnosed type 1 and type 2 diabetes. Methods: Nerve conduction studies (median, ulnar, posterior tibial, peroneal, andsural nerves) were performed for 49 type 1 (27 males, mean 14.1±7.5 years) and 40 type 2 (27 males, 42.0±14.1 years)diabetic patients at onset of diabetes. Children with age at onset under 4 years and adults over 55 years were excludedto eliminate the aging effect and the influence of obstructive arteriosclerosis. Neuropathy was defined as abnormal nerveconduction findings in two or more nerves including the sural nerve. Results: Mean HbA1c level was 12.6±3.3% fortype 1 and 10.5±2.9% for type 2 diabetes. The prevalence of neuropathy was 12.2% for type 1, and 35.0% for type2 diabetes, respectively. There were significant trends in the prevalence of neuropathy with increasing age (p<0.05). The effect of the mean level of glycosylated hemoglobin on the prevalence of polyneuropathy at onset of diabetes wasborderline (p=0.0532). Neither sex of the patients nor the type of diabetes affected the neurophysiologic abnormalitiesat the diagnosis. Conclusions: Even in a population with diabetes at the diagnosis, the prevalence of subclinical neuropathywas not low. Neuropathy has been significantly associated with increasing age indicating the possibility of longerduration of undetected diabetes among them, especially in type 2 diabetes. (Korean J Clin Neurophysiol 2014;16:8-14)
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