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No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients

박지영|김승현|김린|강승걸|김용구|박영민|이헌정|Jung-Eun Choi
대한신경정신의학회 (Korean Neuropsychiatric Association)|2011.03|PSYCHIATRY INVESTIGATION|제8권 제1호|pp. 49-54

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참고문헌

키워드

SchizophreniaAssociationPolymorphismTardive dyskinesiaDopamine receptor
주제분류정신과학

초록

Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic-induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.

Abstract

Objective Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. Dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of TD and dopamine D2 receptors (DRD2) has been regarded as a candidate gene for TD because the antipsychotics have potent antagonism DRD2. This study was aimed to find the relationship between DRD2 gene and antipsychotic-induced TD. Methods We evaluated whether 5 DRD2 single nucleotide polymorphisms (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) are associated with antipsychotic-induced TD in 263 Korean schizophrenia patients with (n=100) and without TD (n=163) who were matched for antipsychotic drug exposure and other relevant variables. Haplotype analyses were also performed. Results None of 5 polymorphisms were found to be significantly associated with TD and with TD severity as measured by Abnormal Involuntary Movement Scale. Overall haplotype (-141Cins>del/TaqID/NcoI/Ser311Cys/TaqIA) frequency was also not significantly different between TD and non-TD groups, although one rare haplotype (I-D1-T-G-A1) showed significantly different frequency between TD and non-TD groups (2.7% vs. 8.5%, respectively, p=0.031). Conclusion The present study does not support that DRD2 gene may be involved in TD in the Korean population, although further studies are warranted.

참고문헌 (49)

  1. Jeste DV, "Tardive dyskinesia", Schizophr Bull, 19, pp.303~315 (1993)
  2. Kane JM, "Epidemiological aspects of tardive dyskinesia", Encephale, 14, pp.191~194 (1988)
  3. Tarsy D, "Epidemiology of tardive dyskinesia: is risk declining with modern antipsychotics?", Mov Disord, 21, pp.589~598 (2006)
  4. Tamminga CA, "Neuroleptic- induced vacuous chewing movements as an animal model of tardive dyskinesia: a study in three rat strains", Psychopharmacology, 102, pp.474~478 (1990)
  5. Yassa R, "Familial tardive dyskinesia", Am J Psychiatry, 138, pp.1618~1619 (1981)
  6. Tarsy D, "The pathophysiologic basis of tardive dyskinesia", Biol Psychiatry, 12, pp.431~450 (1977)
  7. Hsieh CJ, "Genetic variability in serotonin receptor and transporter genes may influence risk for tardive dyskinesia in chronic schizophrenia", Psychiatry Res (2010)
  8. Casey DE, "gamma-Acetylenic GABA in tardive dyskinesia", Arch Gen Psychiatry, 37, pp.1376~1379 (1980)
  9. Andreassen OA, "Neurotoxicity associated with neuroleptic- induced oral dyskinesias in rats. Implications for tardive dyskinesia", Prog Neurobiol, 61, pp.525~541 (2000)
  10. Thelma B, "Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics", Pharmacogenomics, 9, pp.1285~1306 (2008)
  11. Gunne LM, "Association with persistent neuroleptic- induced dyskinesia of regional changes in brain GABA synthesis", Nature, 309, pp.347~349 (1984)
  12. Burt DR, "Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain", Science, 196, pp.326~328 (1977)
  13. Waddington JL, "Spontaneous orofacial dyskinesia and dopaminergic function in rats after 6 months of neuroleptic treatment", Science, 220, pp.530~532 (1983)
  14. Hall H, "Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain", Neuropsychopharmacology, 11, pp.245~256 (1994)
  15. Clow A, "Changes in dopamine-mediated behaviour during one year’s neuroleptic administration", Eur J Pharmacol, 57, pp.365~375 (1979)
  16. Christensen AV, "On the supersensitivity of dopamine receptors, induced by neuroleptics", Psychopharmacology, 48, pp.1~6 (1976)
  17. Tarsy D, "Pharmacologically induced behavioural supersensitivity to apomorphine", Nat New Biol, 245, pp.262~263 (1973)
  18. Beasley CM, "Randomised double-blind comparison of the incidence of tardive dyskinesia in patients with schizophrenia during longterm treatment with olanzapine or haloperidol", Br J Psychiatry, 174, pp.23~30 (1999)
  19. Jeste DV, "Conventional vs. newer antipsychotics in elderly patients", Am J Geriatr Psychiatry, 7, pp.70~76 (1999)
  20. Kane JM, "Does clozapine cause tardive dyskinesia", J Clin Psychiatry, 54, pp.327~330 (1993)
  21. Chen CH, "Association of TaqI A polymorphism of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia", Biol Psychiatry, 41, pp.827~829 (1997)
  22. Liou YJ, "The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia", Schizophr Res, 86, pp.323~325 (2006)
  23. Zai CC, "Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients", Int J Neuropsychopharmacol, 10, pp.639~651 (2007)
  24. Srivastava V, "Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms", Pharmacogenet Genomics, 16, pp.111~117 (2006)
  25. Basile VS, "Pharmacogenomics in schizophrenia: the quest for individualized therapy", Hum Mol Genet, 11, pp.2517~2530 (2002)
  26. Chong SA, "Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia", Am J Med Genet B Neuropsychiatr Genet, 116B, pp.51~54 (2003)
  27. de Leon J, "Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness", J Clin Psychopharmacol, 25, pp.448~456 (2005)
  28. Lattuada E, "Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment", Int J Neuropsychopharmacol, 7, pp.489~493 (2004)
  29. Kaiser R, "Relationship between adverse effects of antipsychotic treatment and dopamine D(2) receptor polymorphisms in patients with schizophrenia", Mol Psychiatry, 7, pp.695~705 (2002)
  30. Zai CC, "Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients", Mol Psychiatry, 12, pp.794~795 (2007)
  31. Han OS, "Structured Clinical Interview for DSM-IV Axis I Disorder- Korean Version" (2000), Hana Medical Publishing
  32. Guy W, "Abnormal Involuntary Movement Scale (AIMS); ECDEU assessment manual for psychopharmacology", pp.534~537 (1976), U.S. Dept. of Health, Education and Welfare
  33. Schooler NR, "Research diagnoses for tardive dyskinesia", Arch Gen Psychiatry, 39, pp.486~487 (1982)
  34. Kay SR, "The positive and negative syndrome scale (PANSS) for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
  35. Lee HJ, "No association between dopamine D4 receptor gene - 521 C", T polymorphism and tardive dyskinesia in schizophrenia, 200707, pp.55, 47~51
  36. Lee HJ, "No evidence for an association between G protein beta3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia", Hum Psychopharmacol, 22, pp.501~504 (2007)
  37. Kang SG, "No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1545~1548 (2008)
  38. Kang SG, "Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia", NEUROPSYCHOBIOLOGY, 57, pp.22~25
  39. Kang SG, "Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1844~1847 (2008)
  40. Kang SG, "Association study between glutathione S-transferase GST-M1, GST-T1, and GST-P1 polymorphisms and tardive dyskinesia", Hum Psychopharmacol, 24, pp.55~60 (2009)
  41. Dubertret C, "The 3’ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia", Schizophr Res, 67, pp.75~85 (2004)
  42. Kaiser R, "Relationship between adverse effects of antipsychotic treatment and dopamine D(2) receptor polymorphisms in patients with schizophrenia", Mol Psychiatry, 7, pp.695~705 (2002)
  43. Jönsson EG, "Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia", Schizophr Res, 40, pp.31~36 (1999)
  44. Jenkinson CP, "Association of dopamine D2 receptor polymorphisms Ser- 311Cys and Taq1A with obesity or type 2 diabetes mellitus in Pima Indians", Int J Obes Relat Metab Disord, 24, pp.1233~1238 (2000)
  45. Sarkar G, "Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor", Genomics, 11, pp.8~14 (1991)
  46. Erdfelder E, "Buchner. G*POWER: A general power analysis program", Behav Res Meth Instrum Comput, 28, pp.1~11 (1996)
  47. Hori H, "Association between three functional polymorphisms of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia", Am J Med Genet, 105, pp.774~778 (2001)
  48. Wu SN, "Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients", Acta Pharmacol Sin, 27, pp.966~970 (2006)
  49. Han GR, "A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11,D8S1179, D7S820, D13S317 and D5S818", Int J Legal Med, 114, pp.41~44 (2000)

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