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조현병 환자에서의 지연성 운동이상 발생과 세로토닌 1A 수용체유전자 rs6295 다형성과의 연관성

Association Study between Serotonin 1A Receptor Gene rs6295 Polymorphism and Tardive Dyskinesia in Patients with Schizophrenia

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참고문헌

주제분류정신과학

초록

OBJECTIVES Tardive dyskinesia (TD) is a movement disorder that is characterized by hyperkinetic movements. Previous studies have suggested that the serotonergic systems are correlated with TD vulnerability. In this study, the association between a single-nucleotide polymorphism (SNP) of the serotonin 1A receptor gene (HTR1A) rs6295 and TD was investigated. METHODS We investigated whether HTR1A rs6295 SNP is associated with antipsychotic-induced TD in 280 Korean patients with schizophrenia. Patients with schizophrenia having TD (n=105) and those without TD (n=175) were matched for their antipsychotic exposures and other relevant variables. The HTR1A rs6295 SNP was analyzed using polymerase chain reaction (PCR)-based methods. RESULTS There was no significant difference in the distribution of genotypic (χ2=2.70, p=0.26) and allelic (χ2=1.87, p=0.17) frequencies between the patient groups with TD and without TD. There was no significant difference in total abnormal involuntary movement scale score (F=0.39, p=0.68) among the genotype group either. CONCLUSION Although there were no differences in genotypic and allelic frequency between patient groups with and without TD, further studies on association of TD with other SNPs of HTRA1 are needed to understand the pathophysiological mechanism of TD.

Abstract

OBJECTIVES Tardive dyskinesia (TD) is a movement disorder that is characterized by hyperkinetic movements. Previous studies have suggested that the serotonergic systems are correlated with TD vulnerability. In this study, the association between a single-nucleotide polymorphism (SNP) of the serotonin 1A receptor gene (HTR1A) rs6295 and TD was investigated. METHODS We investigated whether HTR1A rs6295 SNP is associated with antipsychotic-induced TD in 280 Korean patients with schizophrenia. Patients with schizophrenia having TD (n=105) and those without TD (n=175) were matched for their antipsychotic exposures and other relevant variables. The HTR1A rs6295 SNP was analyzed using polymerase chain reaction (PCR)-based methods. RESULTS There was no significant difference in the distribution of genotypic (χ2=2.70, p=0.26) and allelic (χ2=1.87, p=0.17) frequencies between the patient groups with TD and without TD. There was no significant difference in total abnormal involuntary movement scale score (F=0.39, p=0.68) among the genotype group either. CONCLUSION Although there were no differences in genotypic and allelic frequency between patient groups with and without TD, further studies on association of TD with other SNPs of HTRA1 are needed to understand the pathophysiological mechanism of TD.

참고문헌 (53)

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관련 논문AI추천

No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients김린, 강승걸, 김승현, 김용구, 박영민, 박지영, 이헌정, Jung-Eun Choi대한신경정신의학회 · PSYCHIATRY INVESTIGATION2011 · 제8권 제1호No Association between Dopamine D3 Receptor Gene Ser9Gly Polymorphism and Tardive Dyskinesia in Schizophrenia김린, 강승걸, 박영민, 이헌정, 임세원, Jung-Eun Choi대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2008 · 제6권 제2호Tryptophan Hydroxylase 2 유전자다형성과 항정신병약물로 유발된 지연성운동장애의 연관성김린, 강승걸, 김석주, 박영민, 이종훈, 이헌정대한조현병학회 · 대한조현병학회지2012 · 제15권 제1호The Association between Tardive Dyskinesia Induced by Haloperidol and Polymorphismsin the Serotonin Transporter Gene and Catecholamine-O- Methyltransferase Gene in KoreanSchizophrenic PatientsBaik-Seok Kee, Chul Na, Doug-Hyun Han, Jong-Hun Lee, Kyung Joon Min, Young-Sik Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2005 · 제3권 제1호정신분열병환자에서 만발성 운동장애와 5-HT6 수용체 유전자 다형성(267C/T)과의 관계김동현, 전용호, 한상우대한생물정신의학회 · 생물정신의학2004 · 제11권 제1호한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구김정란, 김태성, 왕성근, 이영호, 지익성, 차승민, 최혜인대한생물정신의학회 · 생물정신의학2012 · 제19권 제1호

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