본문 바로가기
KERD
논문KCI 등재

국민건강보험 데이터베이스를 이용한 한국의 소아와 성인에서 주의력결핍 과잉행동장애의 진단율 및 약물 사용 추세 연구

The Diagnostic Rate and Drug Use Trend of Attention Deficit Hyperactivity Disorder Among Children and Adults in Korea Using the National Health Insurance Database

1

조회

0

다운로드

12

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objectives Attention deficit/hyperactivity disorder (ADHD) is a condition characterized by inattention or hyperactivity and impulsivity that hinders function and development. The purpose of this study was twofold, that is, to check the diagnostic rate of ADHD, which is first diagnosed in adulthood as well as in childhood, and to compare drugs prescribed to children and adult patients. Methods This study utilized Health Insurance Review & Assessment Service data from 1 January 2009 to 31 December 2018. Only first entered International Classification of Diseases diagnostic codes were collected. We set the first year as a clearance period, checked changes in drug prescriptions over the years, and investigated differences found between pediatric and adult patients. Results The overall diagnostic rate of ADHD decreased from 71.9 to 69.7 per 100000 people between 2009 and 2012. This reducing trend was noticeable from 2012 and decreased to 43.7 by 2015, and then rose again to 65.4 in 2018. Extended-release formulation of the methylphenidate (ER-MPH) was found to be the most frequently used first drug. Conclusion Overall diagnostic rate decreased from 2009 to 2018, and the incidence of adult ADHD showed a steady increase. For children, ER-MPH was the most prescribed drug at all ages, while osmotic-release oral system formulation of the methylphenidate was most prescribed for adults.

Abstract

Objectives Attention deficit/hyperactivity disorder (ADHD) is a condition characterized by inattention or hyperactivity and impulsivity that hinders function and development. The purpose of this study was twofold, that is, to check the diagnostic rate of ADHD, which is first diagnosed in adulthood as well as in childhood, and to compare drugs prescribed to children and adult patients. Methods This study utilized Health Insurance Review & Assessment Service data from 1 January 2009 to 31 December 2018. Only first entered International Classification of Diseases diagnostic codes were collected. We set the first year as a clearance period, checked changes in drug prescriptions over the years, and investigated differences found between pediatric and adult patients. Results The overall diagnostic rate of ADHD decreased from 71.9 to 69.7 per 100000 people between 2009 and 2012. This reducing trend was noticeable from 2012 and decreased to 43.7 by 2015, and then rose again to 65.4 in 2018. Extended-release formulation of the methylphenidate (ER-MPH) was found to be the most frequently used first drug. Conclusion Overall diagnostic rate decreased from 2009 to 2018, and the incidence of adult ADHD showed a steady increase. For children, ER-MPH was the most prescribed drug at all ages, while osmotic-release oral system formulation of the methylphenidate was most prescribed for adults.

참고문헌 (27)

  1. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders: DSM-5", pp.59~65 (2013), American Psychiatric Association
  2. Polyzoi M, "Estimated prevalence and incidence of diagnosed ADHD and health care utilization in adults in Sweden - a longitudinal population-based register study", Neuropsychiatr Dis Treat, 14, pp.1149~1161 (2018)
  3. Kessler RC, "Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys", Br J Psychiatry, 197, pp.378~385 (2010)
  4. Agnew-Blais JC, "Evaluation of the persistence, remission, and emergence of attention-deficit", hyperactivity disorder in young adulthood, 2016, pp.73, 713~720
  5. Moffitt TE, "Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study", Am J Psychiatry, 172, pp.967~977 (2015)
  6. Caye A, "Attention-deficit", hyperactivity disorder trajectories from childhood to young adulthood : evidence from a birth cohort supporting a late-onset syndrome, 2016, pp.73, 705~712
  7. Barkley RA, "The persistence of attention-deficit", hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder, 2002, pp.111, 279~289
  8. Biederman J, "A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders", Arch Gen Psychiatry, 53, pp.437~446 (1996)
  9. Goldstein S, "Clinicians’ guide to adult ADHD: assessment and intervention", pp.25~46 (2002), Academic Press
  10. Lara C, "Childhood predictors of adult attention-deficit", hyperactivity disorder : results from the World Health Organization World Mental Health Survey Initiative, 2009, pp.65, 46~54
  11. Biederman J, "Age-dependent decline of symptoms of attention deficit hyperactivity disorder : impact of remission definition and symptom type", Am J Psychiatry, 157, pp.816~818 (2000)
  12. Barkley RA, "The nature of executive function(EF)deficits in daily life activities in adults with ADHD and their relationship to performance on EF tests", J Psychopathol Behav Assess, 33, pp.137~158 (2011)
  13. 이재욱, "국내 성인 ADHD 연구 동향 분석", 발달장애연구, 23(3), pp.1~23 (2019), 한국발달장애학회[DOI]
  14. Hong M, "Nationwide rate of attention-deficit hyperactivity disorder diagnosis and pharmacotherapy in Korea in 2008-2011", Asia Pac Psychiatry, 6, pp.379~385 (2014)
  15. Kim KM, "and characteristic factors in adults with remaining childhood attention-deficit hyperactivity symptoms", Int J Psychiatry Clin Pract, 21, pp.236~241 (2017)
  16. Kessler RC, "The prevalence and correlates of adult ADHD in the United States : results from the National Comorbidity Survey Replication", Am J Psychiatry, 163, pp.716~723 (2006)
  17. Hankin CS, "ADHD and its impact on the family", Drug Benefit Trends, 13, pp.15~16 (2001)
  18. Biederman J, "Attention-deficit", hyperactivity disorder : a life-span perspective, 1998, pp.59(Suppl 7), 4~16
  19. Biederman J, "Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up study", Pediatrics, 124, pp.71~78 (2009)
  20. Sobanski E, "Subtype differences in adults with attention-deficit", hyperactivity disorder (ADHD) with regard to ADHD-symptoms, psychiatric comorbidity and psychosocial adjustment, 2008, pp.23, 142~149
  21. Halmøy A, "Occupational outcome in adult ADHD: impact of symptom profile, comorbid psychiatric problems, and treatment: a cross-sectional study of 414 clinically diagnosed adult ADHD patients", J Atten Disord, 13, pp.175~187 (2009)
  22. Nigg JT, "Executive functions and ADHD in adults : evidence for selective effects on ADHD symptom domains", J Abnorm Psychol, 114, pp.706~717 (2005)
  23. Asghari S, "Optimal strategy to identify incidence of diagnostic of diabetes using administrative data", BMC Med Res Methodol, 9, pp.62~ (2009)
  24. Huang CL, "Trends in incidence rates of diagnosed attention-deficit", hyperactivity disorder(ADHD)over 12 years in Taiwan : a nationwide population-based study, 2020, pp.284, 112792~
  25. Holden SE, "The prevalence and incidence, resource use and financial costs of treating people with attention deficit", hyperactivity disorder (ADHD) in the United Kingdom (1998 to 2010), 2013, pp.7, 34~
  26. Chung W, "Trends in the prevalence and incidence of attentiondeficit", hyperactivity disorder among adults and children of different racial and ethnic groups, 2019, pp.2, e1914344~
  27. The survey of mental disorders in Korea, "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2007)

관련 논문AI추천

Prescribing patterns for attention deficit hyperactivity disorder medications among children and adolescents in Korea, 2007-2011송인명, 신주영한국역학회 · Epidemiology and Health2016 · 제38권 Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder Among Adults and Children/Adolescents in Korea박원명, 심세훈, 전덕인, Hyung Mo Sung, Jeong-Cheol Seo, Jeong Seok Seo, Jeongwan Hong, Sung‐Yong Park, Young Sup Woo대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제1호국내 주의력결핍 과잉행동 장애 아동 및 청소년의 약물요법 패턴 및 지속성이경은, 제남경한국임상약학회 · 한국임상약학회지2018 · 제28권 제3호Factors that Affect the Adherence to ADHD Medications during a Treatment Continuation Period in Children and Adolescents: A Nationwide Retrospective Cohort Study Using Korean Health Insurance Data from 2007 to 2011곽영숙, 김봉석, 반건호, 방수영, 손석한, 양재원, 오인환, 이소영, 이연정, 정운선, 정유숙, 최형윤, 홍민하, 황준원대한신경정신의학회 · PSYCHIATRY INVESTIGATION2017 · 제14권 제2호ADHD 및 성인 ADHD에 대한 개념적 고찰 (1): ADHD 진단의 변천-DSM을 중심으로강웅구, 송유진, 안유석대한신경정신의학회 · 신경정신의학2022 · 제61권 제1호주의력결핍 과잉행동장애의 의료적 진단에 대한 고찰이상훈한국정서행동장애학회 · 정서·행동장애연구2018 · 제34권 제4호

이 간행물의 다른 논문 (16건)