국내 주의력결핍 과잉행동 장애 아동 및 청소년의 약물요법 패턴 및 지속성
Patterns and Persistence of Pharmacotherapy for Children and Adolescents with Attention Deficit Hyperactivity Disorder in South Korea
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Objective: This study aimed to assess treatment persistence in Korean children and adolescents with attention deficit hyperactivitydisorder (ADHD) and the factors influencing their adherence to ADHD pharmacotherapy. Methods: The study included patientsbetween 6 and 18 years of age with ADHD who were taking various formulations of methylphenidate and atomoxetine on June 1,2014. Patients were dichotomized as “persistent” or “non-persistent”, depending on whether they continued ADHD therapy for 6months (therapy persistence). We also investigated if the patients were taking the same medication(s) as before and also classifiedthe patients as “medication persistent” or “non-persistent”. Patient’ characteristics were correlated with therapy persistence andmedication persistence. Multiple logistic regression analyses were performed to assess potential risk factors for treatmentpersistence. Results: Overall, 3,317 patients were included in the analysis. A majority of patients were taking stimulants (82.0%),16.2% were taking non-stimulants and 1.8% were taking a combination therapy of stimulants and non-stimulants. After 6 months,2,290 patients (69.0%) continued to take medication for ADHD with 1,953 patients taking the same medication(s) as 6 monthspreviously. Common positive factors for therapy persistence and medication persistence were identified as younger age,retardation, and developmental delay, and long-acting formulations of methylphenidate as either monotherapy or in a combinationtherapy may be used. Conclusion: ADHD medications were proven to improve academic performance and social skills of children. Collaboration between patients, parents, school staffs, and prescribers is required to improve the persistent use of ADHDmedications.
Abstract
Objective: This study aimed to assess treatment persistence in Korean children and adolescents with attention deficit hyperactivitydisorder (ADHD) and the factors influencing their adherence to ADHD pharmacotherapy. Methods: The study included patientsbetween 6 and 18 years of age with ADHD who were taking various formulations of methylphenidate and atomoxetine on June 1,2014. Patients were dichotomized as “persistent” or “non-persistent”, depending on whether they continued ADHD therapy for 6months (therapy persistence). We also investigated if the patients were taking the same medication(s) as before and also classifiedthe patients as “medication persistent” or “non-persistent”. Patient’ characteristics were correlated with therapy persistence andmedication persistence. Multiple logistic regression analyses were performed to assess potential risk factors for treatmentpersistence. Results: Overall, 3,317 patients were included in the analysis. A majority of patients were taking stimulants (82.0%),16.2% were taking non-stimulants and 1.8% were taking a combination therapy of stimulants and non-stimulants. After 6 months,2,290 patients (69.0%) continued to take medication for ADHD with 1,953 patients taking the same medication(s) as 6 monthspreviously. Common positive factors for therapy persistence and medication persistence were identified as younger age,retardation, and developmental delay, and long-acting formulations of methylphenidate as either monotherapy or in a combinationtherapy may be used. Conclusion: ADHD medications were proven to improve academic performance and social skills of children. Collaboration between patients, parents, school staffs, and prescribers is required to improve the persistent use of ADHDmedications.
참고문헌 (52)
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