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Cyclooxygenase-2 Induction in Porphyromonas gingivalis-Infected THP-1 Monocytic Cells

최은경|강인철|오병호
대한구강생물학회 (Korean Academy Of Oral Biology)|2006.03|International Journal of Oral Biology|제31권 제1호|pp. 21-26

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참고문헌

주제분류치의학

초록

Abstract

Periodontopathogens including Porphyromonas gingivalis interact with host periodontal cells and the excessive subsequent host responses contribute a major part to the development of periodontal diseases. Cyclooxygenase (COX)-2-synthesized PGE2 has detrimental activities in terms of periodontal pathogenesis. The present study investigated induction of COX-2 expression by P. gingivalis in human monocytic THP-1 cells. Live P. gingivalis increased expression of COX-2, but not that of COX-1, which was demonstrated at both mRNA and protein levels. Elevated levels of PGE2 were released from P. gingivalis-infected THP-1 cells. Pharma-cological inhibition of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) substantially attenuated P. gingivalis-induced COX-2 mRNA expression. Indeed, activation of p38 MAPK and ERK was observed in P. gingivalis-infected THP-1 cells. Also, P. gingivalis induced activation of nuclear factor-B (NF-B) which is an important transcription factor for COX-2. These results suggest that COX-2 expression is upregulated in P. gingivalis-infected monocytic cells, at least in part, via p38 MAPK, ERK, and NF-B.

참고문헌 (22)

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관련 논문AI추천

Production of pro-inflammatory cytokines by Porphyromonas gingivalis in THP-1 macrophagic cells강인철, Eun-Kyoung Choi대한구강생물학회 · International Journal of Oral Biology2009 · 제34권 제2호Induction of Prostaglandin E2 by Porphyromonas gingivalis in Human Dental Pulp Cells강인철, 김소희, 백윤웅대한구강생물학회 · International Journal of Oral Biology2017 · 제42권 제4호Porphyromonas gingivalis의 각종 표면성분이 싸이토카인 형성에 미치는 영향김성조대한치주과학회 · Journal of Periodontal & Implant Science2005 · 제35권 제3호Chracterization of THP-1 Cell Death Induced by Porphyromonas gingivalis Infection정진, 김세연, 나희삼, 박미희, 송유리대한구강생물학회 · International Journal of Oral Biology2017 · 제42권 제1호Porphyromonas Gingivalis Invasion of Human Aortic Smooth Muscle Cells이성만, 이진용, 이현우대한구강생물학회 · International Journal of Oral Biology2008 · 제33권 제4호Comparison of Cytokine Gene Induction in RAW 264.7 Cells by Porphyromonas gingivalis and Escherichia coli Lipopolysaccharide정진, 나희삼, Hae-Ryoun Park, So-Yeon Jeong, Sung-Hee Jeong, Young-Hwa Lee대한구강생물학회 · International Journal of Oral Biology2010 · 제35권 제3호

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