골관절염 유발이 흰쥐의 에너지소비량 및 에너지 기질 이용에 미치는 영향
Effects of Osteoarthritis Induction on Energy Expenditure and Energy Substrate Utilization in White Rats
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본 연구의 목적은 골관절염 유발이 흰쥐의 에너지소비량과 에너지기질이용에 미치는 영향을 확인하고자 실시하였다. 흰쥐의 무릎 관절강 내에 Monosodium iodoacetate(MIA)를 주입하여 2주 동안 관절염을 유발시켰고, 이후 족적평가와 더불어 대사챔버에 넣어 에너지소비량과 에너지 기질 이용을 평가했다. 본 연구의 결과 첫째, 골관절염 모델은족적평가 시 통증 및 보행 문제로 대조군에 비해 족적 강도가 낮은 것으로 나타났다(p<.001). 둘째, 골관절염 모델은대조군에 비해 산소섭취량과 에너지소비량이 더 낮은 것으로 나타났다(p<.01, p<.05). 셋째, 골관절염 모델은 대조군에 비해 탄수화물 산화량이 높았으며 지방 산화량의 경우 더 낮은 것으로 나타났다(p<.05, p<.01). 결론적으로 골관절염 유발은 전체적인 활동량을 줄어들게 하여 총에너지 소비량을 감소를 가져오는 것으로 나타났으며, 이 때 사용되는에너지원은 주로 탄수화물로써 세포의 복구와 생산 메커니즘인 것으로 사료된다. 향후 골관절염 모델에서 혈액분석및 에너지대사에 관여하는 유전자의 생화학분석을 통해 골관절염 시 에너지섭취와 소비에 대한 추가적 연구가 필요할것으로 판단된다.
Abstract
The purpose of this study was to investigate the effect on energy expenditure and energy substrate utilization for 24 hours in an osteoarthritis model. In the MIA group, arthritis was induced for 2 weeks by injecting MIA into the joint cavity of the knee, followed by foot print evaluation. In addition, energy expenditure and energy substrate utilization were measured for 24 hours in metabolic chamber. As a result of this study, first, the osteoarthritis model showed lower footprint intensity than the control group due to pain and gait problems during foot evaluation (p<.001). Second, the osteoarthritis model showed lower oxygen uptake and energy expenditure than the control group (p<.01, p<.05). Third, the osteoarthritis model showed higher carbohydrate oxidation and lower fat oxidation compared to the control group (p<.05, p<.01). In conclusion, it was shown that osteoarthritis induction reduces overall activity and thus reduces total energy expenditure, and the energy substrate used at this time is mainly carbohydrate, which is thought to be the result of the cell's recovery and production mechanism.
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