안정 시 심박수와 이상지질혈증 및 당뇨병과의 관련성
Association of Resting Heart Rate and Dyslipidemia and Diabetes in 2018 National Health and Nutrition Examination Survey
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연구배경: 당뇨병의 위험요인으로 거론되는 요인 중 높은안정 시 심박수와 관련성을 분석해 안정 시 심박수가 당뇨병에 미치는 영향을 파악하고자 하였다. 방법: 본 연구의 대상은 제7기 3차년도(2018) 국민건강영양조사에 참여한 사람 중 공복혈당 검사 자료가 있는 6,622명을 대상으로 분석을 하였다. 공복혈당은 126 mg/dL 이상일때 당뇨병군으로 정의하고 다중 로지스틱회귀분석을 이용하여 일반적 특성, 생활습관, 혈액 화학적 검사 결과를 보정하여 안정 시 심박수 수준에 따른 당뇨병과의 관련성을 알아보았다. 결과: 안정 시 심박수 수준에 따른 교차비는 2nd에서는1.434배, 3rd에서는 1.714배, 4th에서는 1.785배로 안정 시심박수가 증가함에 따라 당뇨병 발생률이 증가하였으며, 다른 관련 변수들을 모두 통제한 상태에서 분석된 model 4에서도 통계적으로 유의하지 않았던 2nd를 제외한 3rd, 4th에서 발생할 확률은 각각 2.364배, 3.477배로 안정 시 심박수가증가함에 따라 발생률이 증가하는 것으로 나타났다. 결론: 높은 안정 시 심박수는 당뇨병 증가와 관련이 있음을 보여주며, 당뇨병 위험을 예측하는 데 유용한 도구가 될수 있음을 시사한다
Abstract
Background: As a risk factor for diabetes, there are many evidences for physical characteristics and lifestyle habits. There are studies showing that resting heart rate is also related, but evidence is still lacking. Therefore, this study attempted to determine the effect of resting heart rate on diabetes. Methods: The subject of this study was analyzed with 6,622 people who had fasting blood glucose test data out of a total of 7,993 people who participated in the 7th National Health and Nutrition Survey. Fasting blood glucose above 126 mg/dL was defined as a diabetic group and a multiple logistic regression analysis was used. General characteristics, lifestyle and blood chemistry test results were adjusted to investigate the association with diabetes according to the resting heart rate level in the subjects. Results: The risk of diabetes according to the resting heart rate level was 1.434 times in the 2nd quartile, 1.714 times in the 3rd and 1.785 times in the 4th, compared to the 1st quartile. In model 4, except for the 2nd, which was not significant the analysis with all related variables adjusted for the risk rate in the 3rd and 4th order showed that the risk rate increased to 2.364 times and 3.477 times, respectively as the resting heart rate increased. Conclusions: This study shows that high resting heart rate is associated with increased diabetes, and suggests that high heart rate, along with other known risk factors, may be a useful tool in predicting diabetes risk
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