적콜라비싹추출물의 항산화, 항염 및 미백 효과
Anti-Inflammatory, Anti-Oxidant and Melanin Synthesis Inhibitory Effects of Red Kohlrabi (Brassica oleracea var. gongylodes) Sprouts Extract
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This study is for evaluating red kohlrabi (Brassica oleracea var. gongylodes) sprouts as cosmetic ingredient. The sprouts were grown under different light conditions: white, red, blue and dark. We examined biological activities of sprouts extracts to reveal anti-oxidant, anti-inflammatory and skin-brightening effects. In DPPH radical scavenging assay, sprouts grown under the white light showed the best performance, demonstrating the optimized cultivation of raw materials. In melanin synthesis inhibition assays, red kohlrabi sprouts extracts showed concentration-dependent activity, suggesting skin whitening efficacy as a cosmetic ingredient. More interestingly, the extracts showed significantly high activities of NO suppression in macrophages, which is implicated in anti-inflammatory agents of both cosmetic and pharmaceutical industries. Decrease of NO synthesis was up to 80% in our tests, and we subsequently elucidated that TNF-α is reduced by the extracts, leading to the reduction of NO. Light conditions did not seem to modulate skin whitening and anti-inflammatory efficacies, but we could conclude that white light is the best condition given that antioxidant activity was significantly better than the other 3 conditions. With these results, we uncovered the beneficial effects of red kohlrabi sprouts extracts as a cosmetic ingredient, and demonstrated that plant factory system with different light conditions can serve to supply industry-optimized raw materials.
Abstract
This study is for evaluating red kohlrabi (Brassica oleracea var. gongylodes) sprouts as cosmetic ingredient. The sprouts were grown under different light conditions: white, red, blue and dark. We examined biological activities of sprouts extracts to reveal anti-oxidant, anti-inflammatory and skin-brightening effects. In DPPH radical scavenging assay, sprouts grown under the white light showed the best performance, demonstrating the optimized cultivation of raw materials. In melanin synthesis inhibition assays, red kohlrabi sprouts extracts showed concentration-dependent activity, suggesting skin whitening efficacy as a cosmetic ingredient. More interestingly, the extracts showed significantly high activities of NO suppression in macrophages, which is implicated in anti-inflammatory agents of both cosmetic and pharmaceutical industries. Decrease of NO synthesis was up to 80% in our tests, and we subsequently elucidated that TNF-α is reduced by the extracts, leading to the reduction of NO. Light conditions did not seem to modulate skin whitening and anti-inflammatory efficacies, but we could conclude that white light is the best condition given that antioxidant activity was significantly better than the other 3 conditions. With these results, we uncovered the beneficial effects of red kohlrabi sprouts extracts as a cosmetic ingredient, and demonstrated that plant factory system with different light conditions can serve to supply industry-optimized raw materials.
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