Primary Thymic Mucinous Adenocarcinoma: A Case Report
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Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.
Abstract
Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.
참고문헌 (9)
- Suster S, "Thymic carcinoma: update of current diagnostic criteria and histologic types", Semin Diagn Pathol, 22, pp.198~212 (2005)
- Maeda D, "Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma", Lung Cancer, 64, pp.22~27 (2009)
- Ra SH, "Mucinous adenocarcinomas of the thymus: report of 2 cases and review of the literature", Am J Surg Pathol, 31, pp.1330~1336 (2007)
- Choi WW, "Adenocarcinoma of the thymus: report of two cases, including a previously undescribed mucinous subtype", Am J Surg Pathol, 27, pp.124~130 (2003)
- Seki Y, "Mucinous adenocarcinoma of the anterior mediastinum", Kyobu Geka, 57, pp.413~416 (2004)
- Takahashi F, "Adenocarcinoma of the thymus: mucinous subtype", Hum Pathol, 36, pp.219~223 (2005)
- Kapur P, "Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature", Arch Pathol Lab Med, 130, pp.201~204 (2006)
- Okuda M, "Clear cell carcinoma originating from ectopic thymus", Gen Thorac Cardiovasc Surg, 57, pp.269~271 (2009)
- Morikawa H, "Papillary adenocarcinoma developed in a thymic cyst", Gen Thorac Cardiovasc Surg, 58, pp.295~297 (2010)