Micronodular Thymoma with Lymphoid Stroma in a Multilocular Thymic Cyst: A Case Study
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Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called “unusual” variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.
Abstract
Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called “unusual” variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.
참고문헌 (10)
- Suster S, "Multilocular thymic cyst: an acquired reactive process. Study of 18 cases", Am J Surg Pathol, 15, pp.388~398 (1991)
- Müller-Hermelink HK, "Tumours of the thymus, In World Health Organization classification of tumours: pathology and genetics of tumours of the lung, pleura, thymus and heart", pp.145~247 (2004), IARC Press
- Song HJ, "Micronodular thymoma with lymphoid stroma: a case report", J Lung Cancer, 10, pp.56~58 (2011)
- Rieker RJ, "Cystic thymoma", Pathol Oncol Res, 11, pp.57~60 (2005)
- Suster S, "Problem areas and inconsistencies in the WHO classification of thymoma", Semin Diagn Pathol, 22, pp.188~197 (2005)
- Moran CA, "Rhabdomyomatous thymoma", Am J Surg Pathol, 17, pp.633~636 (1993)
- Weissferdt A, "Micronodular thymic carcinoma with lymphoid hyperplasia: a clinicopathological and immunohistochemical study of five cases", Mod Pathol, 25, pp.993~999 (2012)
- El MF, "Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case", Pathology, 38, pp.586~588 (2006)
- Nakamura S, "Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation", Am J Surg Pathol, 36, pp.1857~1864 (2012)
- Sugio K, "Thymoma arising in a thymic cyst", Ann Thorac Cardiovasc Surg, 6, pp.329~331 (2000)