Effects of L-carnitine on the orchidectomized rats
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This was conducted to determine the effects of body weight, organ weight, hematological values and biochemical parameters by L-carnitine (Carn) on the orchidectomized (Orch) rats. The animals were divided into 4 groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. Orch group received operation and no treatment. Orch＋Carn received operation and L-carnitine. The body weights of each group increased, but that of the Orch＋Carn group were significantly lower than those in all the other groups. There were significant differences (P＜0.05, P＜0.001) of body weights between Orch＋Carn group and all the other groups. Also, organ weights such as heart, liver, spleen and kidney were measured. The heart weights were significantly lower (P＜0.001) in the Orch＋Carn group than those in Intact and Sham groups, respectively. The weights of liver and kidney in the Orch＋Carn group showed significant differences (P＜0.001) in comparison with those in all the other groups. Also, the spleen weights were significantly lower (P＜0.05) in the Orch＋Carn group than those in Intact and Sham groups, respectively. The hematological values of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were significant differences (P＜0.05, P＜0.01, P＜0.001) in comparison with those in all the other groups. On the other hand, the hematological values of white blood cell (WBC), red blood cell (RBC) and mean corpuscular hemoglobin concentration (MCHC) resulted in no significant differences in any other groups. The concentrations of total cholesterol (T-chol), triglyceride (TG) and high density lipoprotein (HDL) decreased significantly (P＜0.05) in the Orch＋Carn group as compared to those in the Orch group. We conclude that L-carnitine was significantly decreased the body weight in the orchidectomized rats. Our findings suggest that L-carnitine may influence the process of lipid packaging and absorption in the orchidectomized rats.
Abstract
This was conducted to determine the effects of body weight, organ weight, hematological values and biochemical parameters by L-carnitine (Carn) on the orchidectomized (Orch) rats. The animals were divided into 4 groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. Orch group received operation and no treatment. Orch＋Carn received operation and L-carnitine. The body weights of each group increased, but that of the Orch＋Carn group were significantly lower than those in all the other groups. There were significant differences (P＜0.05, P＜0.001) of body weights between Orch＋Carn group and all the other groups. Also, organ weights such as heart, liver, spleen and kidney were measured. The heart weights were significantly lower (P＜0.001) in the Orch＋Carn group than those in Intact and Sham groups, respectively. The weights of liver and kidney in the Orch＋Carn group showed significant differences (P＜0.001) in comparison with those in all the other groups. Also, the spleen weights were significantly lower (P＜0.05) in the Orch＋Carn group than those in Intact and Sham groups, respectively. The hematological values of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were significant differences (P＜0.05, P＜0.01, P＜0.001) in comparison with those in all the other groups. On the other hand, the hematological values of white blood cell (WBC), red blood cell (RBC) and mean corpuscular hemoglobin concentration (MCHC) resulted in no significant differences in any other groups. The concentrations of total cholesterol (T-chol), triglyceride (TG) and high density lipoprotein (HDL) decreased significantly (P＜0.05) in the Orch＋Carn group as compared to those in the Orch group. We conclude that L-carnitine was significantly decreased the body weight in the orchidectomized rats. Our findings suggest that L-carnitine may influence the process of lipid packaging and absorption in the orchidectomized rats.
참고문헌 (12)
- Bremer J, "Carnitine-metabolism and functions", Physiol Rev, 63(4), pp.1420~1480 (1983)
- Broderick TL, "Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart", J Biol Chem, 267(6), pp.3758~3763 (1992)
- Costa ND, "Case report: efficacy of oral carnitine therapy for dilated cardiomyopathy in boxer dogs", J Nutr, 124(12), pp.2687~2692 (1994)
- Dayanandan A, "Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats", J Nutr Biochem, 12(5), pp.254~257 (2001)
- Derin N, "L-carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation", J Physiol Pharmacol, 55(3), pp.595~606 (2004)
- Guyton AC, "Textbook of medical physiology", pp.869~899 (1996), Saunders
- Holloway GP, "Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle", J Physiol, 582(1), pp.393~405 (2007)
- Keene BW, "Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy", J Am Vet Med Assoc, 198(4), pp.647~650 (1991)
- Keene BW, "L-Carnitine deficiency in canine dilated cardiomyopathy, In: Current Veterinary Therapy XI: Small Animal Practice", pp.780~783 (1992), WB Saunders
- 박태선, "A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet", Genes And Nutrition, 2(4), pp.353~358
- Rebouche CJ, "Kinetic compartmental analysis of carnitine metabolism in the dog", Arch Biochem Biophys, 220(1), pp.60~70 (1983)
- 노상규, "Dietary L-carnitine enhances the lymphatic absorption of fat and α-tocopherol in ovariectomized rats", Journal of Nutrition, 135(4), pp.753~756, American Society for Nutritional Sciences