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Effects of estrogen on the ovariectomized rat
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The aim of this study was to determine the effects of body weight, organ weight, hematological values and biochemical parameters by estrogen on the ovariectomized (OVX) rats. The animals were divided into 4groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. OVX group (n=10) received operation and no treatment. OVX+E2 (n=10)received operation and estrogen. The body weight of each group increased, but that of OVX+E2 group decreased. There were very significant differences (P⁄0.001) of body weights between OVX+E2 group and the other groups. Also, the wight of important organs such as heart, liver, spleen and kidney was measured. The heart weight was significantly lower (P⁄0.05) in the OVX+E2 group than the Intact group. The liver weight of the OVX+E2 group was significantly different in comparison with those of the other groups. On the other hand, there were no significantly differences in the organ weight of spleen and kidney between the OVX+E2 group and the other remaining groups. The hematological values of WBC, RBC,MCV, MCH and MCHC were not significantly different among the groups. The serum total protein and albumin decreased significantly in the OVX+E2 group as compared to those in the intact group. But, there were no significant differences in Ca, IP and Mg among the groups. We conclude that estrogen was significantly decreased the body weight in the ovariectomized rats. Our findings suggest that estrogen may influence the process of lipid packaging and absorption in the ovariectomized rats.
Abstract
The aim of this study was to determine the effects of body weight, organ weight, hematological values and biochemical parameters by estrogen on the ovariectomized (OVX) rats. The animals were divided into 4groups. Intact group (n=10) received no treatment and operation. Sham group (n=10) received only sham operation and no treatment. OVX group (n=10) received operation and no treatment. OVX+E2 (n=10)received operation and estrogen. The body weight of each group increased, but that of OVX+E2 group decreased. There were very significant differences (P⁄0.001) of body weights between OVX+E2 group and the other groups. Also, the wight of important organs such as heart, liver, spleen and kidney was measured. The heart weight was significantly lower (P⁄0.05) in the OVX+E2 group than the Intact group. The liver weight of the OVX+E2 group was significantly different in comparison with those of the other groups. On the other hand, there were no significantly differences in the organ weight of spleen and kidney between the OVX+E2 group and the other remaining groups. The hematological values of WBC, RBC,MCV, MCH and MCHC were not significantly different among the groups. The serum total protein and albumin decreased significantly in the OVX+E2 group as compared to those in the intact group. But, there were no significant differences in Ca, IP and Mg among the groups. We conclude that estrogen was significantly decreased the body weight in the ovariectomized rats. Our findings suggest that estrogen may influence the process of lipid packaging and absorption in the ovariectomized rats.
참고문헌 (24)
- Arjmandi BH, "Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis", J Nutr, 126(1), pp.161~167 (1996)
- Arnold S, "Effect of duration of PMSG treatment on induction of oestrus, pregnancy rates and the complications of hyper-oestrogenism in dogs", J Reprod Fertil Suppl, 39, pp.115~122 (1989)
- Arnold S, "Urinary incontinence in spayed bitches: new insights into the pathophysiology and options for medical treatment", Reprod Domest Anim, 44(2S), pp.190~192 (2009)
- Bowen RA, "Efficacy and toxicity of estrogens commonly used to terminate canine pregnancy", J Am Vet Med Assoc, 186(8), pp.783~788 (1985)
- Bradley KJ, "Dysuria resulting from an encapsulated haematoma in a recently spayed bitch", J Small Anim Pract, 41(10), pp.465~467 (2000)
- Dow SW, "Perianal adenomas and hypertestosteronemia in a spayed bitch with pituitary- dependent hyperadrenocorticism", J Am Vet Med Assoc, 192(10), pp.1439~1441 (1988)
- Eilts BE, "Pregnancy termination in the bitch and queen", Clin Tech Small Anim Pract, 17(3), pp.116~123 (2002)
- Guo HY, "Orally administered lactoferrin preserves bone mass and microarchitecture in ovariectomized rats", J Nutr, 139(5), pp.958~964 (2009)
- Houpt KA, "Taste preferences and their relation to obesity in dogs and cats", Can Vet J, 22(4), pp.77~85 (1981)
- Kalu DN, "Skeletal response of ovariectomized rats to low and high doses of 17 beta-estradiol", Bone Miner, 14(3), pp.175~187 (1991)
- Kawakami E, "High plasma estradiol-17beta levels in dogs with benign prostatic hyperplasia and azoospermia", J Vet Med Sci, 63(4), pp.407~412 (2001)
- Misner TL, "Animal behavior case of the month. Aggression that began 4 days after ovariohysterectomy", J Am Vet Med Assoc, 213(9), pp.1260~1262 (1998)
- Nelson RW, "Pyometra", Vet Clin North Am Small Anim Pract, 16(3), pp.561~576 (1986)
- Raisz LG, "Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture", Endocrinology, 122(3), pp.1083~1086 (1988)
- Ryan KJ, "Biochemistry of aromatase: significance to female reproductive physiology", Cancer Res, 42(8S), pp.3342~3344 (1982)
- Saini HK, "Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia-reperfusion", Am J Physiol Heart Circ Physiol, 288(5), pp.H2260~H2270 (2005)
- Sanpera N, "Oestrogen-induced bone marrow aplasia in a dog with a sertoli cell tumour", J Small Anim Pract, 43(8), pp.365~369 (2002)
- Sokolowski JH, "False pregnancy", Vet Clin North Am Small Anim Pract, 12(1), pp.93~98 (1982)
- Sontas HB, "Estrogeninduced myelotoxicity in dogs: A review", Can Vet J, 10, pp.1054~1058 (2009)
- Steinetz BG, "Plasma relaxin levels in pregnant and lactating dogs", Biol Reprod, 37(3), pp.719~725 (1987)
- Stöcklin-Gautschi NM, "The relationship of urinary incontinence to early spaying in bitches", J Reprod Fertil Suppl, 57, pp.233~236 (2001)
- Van Cromphaut SJ, "Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin Dreceptor-independent mechanisms", J Bone Miner Res, 18(10), pp.1725~1736 (2003)
- Wu Q, "Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia- reperfusion", Exp Physiol, 93(9), pp.1034~1043 (2008)
- Zou W, "Dietary L-carnitine enhances the lymphatic absorption of fat and alphatocopherol in ovariectomized rats", J Nutr, 135(4), pp.753~756 (2005)