알코올 의존 환자에서 삼대립 세로토닌 수송체 유전자 다형성과 생활사건 스트레스가 우울증에 미치는 영향
The Effects of Triallelic Serotonin Transporter Gene Polymorphism and Stressful Life Event on Depression in Patients with Alcohol Dependence
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives:The purpose of this study is to investigate the relationship between the triallelic serotonin transporter gene and stressful life events to determine their effect on depression with alcohol dependence. Methods:Ninety-five hospitalized patients with alcohol dependence (73 male, 22 female) were enrolled in this study. Thirty-two (33.7%) of the total patients were diagnosed with major depressive disorder and dysthymic disorder by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV. The characteristics of stress were evaluated using the stressful life events scale, and depressive symptoms were assessed using the depression scale (Beck Depression Inventory, BDI). Alcoholism with depression (n = 32) and alcoholism without depression (n = 63) were genotyped for the triallelic serotonin transporter gene (LA : higher expressing allele, LG/S : lower expressing allele). Results:There was no significant difference in the allele frequency between the depression group and the non-depression group (χ2 = 0.345, p = 0.619). LG/S alleles had more comorbid depression in the higher score of stressful life events scale [Mental-Haenszel (MH)-χ2 = 4.477, p = 0.034]. But there was no significant difference in the comorbidity according to the scores from the stressful life event scale in the LA alleles (MH-χ2 = 0.741, p = 0.399). In the results, alcohol-dependent individuals with LG/S alleles had more comorbid depression than those with LA alleles when they had experienced severe stressful life events (MH-odds ratio = 2.699, p = 0.028). Conclusions:These results suggest that there is no direct relationship between triallelic serotonin transporter gene and depression in the alcohol dependent patients. But alcohol dependent individuals with the lower expressing alleles of the serotonin transporter gene were more susceptible to depression than those with the higher expressing alleles in response to stressful life events.
Abstract
Objectives:The purpose of this study is to investigate the relationship between the triallelic serotonin transporter gene and stressful life events to determine their effect on depression with alcohol dependence. Methods:Ninety-five hospitalized patients with alcohol dependence (73 male, 22 female) were enrolled in this study. Thirty-two (33.7%) of the total patients were diagnosed with major depressive disorder and dysthymic disorder by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV. The characteristics of stress were evaluated using the stressful life events scale, and depressive symptoms were assessed using the depression scale (Beck Depression Inventory, BDI). Alcoholism with depression (n = 32) and alcoholism without depression (n = 63) were genotyped for the triallelic serotonin transporter gene (LA : higher expressing allele, LG/S : lower expressing allele). Results:There was no significant difference in the allele frequency between the depression group and the non-depression group (χ2 = 0.345, p = 0.619). LG/S alleles had more comorbid depression in the higher score of stressful life events scale [Mental-Haenszel (MH)-χ2 = 4.477, p = 0.034]. But there was no significant difference in the comorbidity according to the scores from the stressful life event scale in the LA alleles (MH-χ2 = 0.741, p = 0.399). In the results, alcohol-dependent individuals with LG/S alleles had more comorbid depression than those with LA alleles when they had experienced severe stressful life events (MH-odds ratio = 2.699, p = 0.028). Conclusions:These results suggest that there is no direct relationship between triallelic serotonin transporter gene and depression in the alcohol dependent patients. But alcohol dependent individuals with the lower expressing alleles of the serotonin transporter gene were more susceptible to depression than those with the higher expressing alleles in response to stressful life events.
참고문헌 (31)
- Owens MJ, "Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter", Clin Chem, 40, pp.288~295 (1994)
- Heils A, "Allelic variation of human serotonin transporter gene expression", J Neurochem, 66, pp.2621~2624 (1996)
- Lesch KP, "Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region", Science, 274, pp.1527~1531 (1996)
- Lesch KP, "The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes", J Mol Med (Berl), 74, pp.365~378 (1996)
- Nakamura M, "The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants", Mol Psychiatry, 5, pp.32~38 (2000)
- Hu X, "An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk", Alcohol Clin Exp Res, 29, pp.8~16 (2005)
- Gelernter J, "Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects", Hum Genet, 101, pp.243~246 (1997)
- Collier DA, "The serotonin transporter is a potential susceptibility factor for bipolar affective disorder", Neuroreport, 7, pp.1675~1679 (1996)
- Seretti A, "Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders", Mol Psychiatry, 4, pp.280~283 (1999)
- Caspi A, "Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene", Science, 301, pp.386~389 (2003)
- Kim JM, "Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders", BIOLOGICAL PSYCHIATRY, 62(5), pp.423~428 (2007), ELSEVIER SCIENCE INC
- Park JY, "Effects of triallelic serotonin transporter gene and stressful life events on early adulthood depression", pp.2010
- Helzer JE, "Alcoholism--North America and Asia. A comparison of population surveys with the Diagnostic Interview Schedule", Arch Gen Psychiatry, 47, pp.313~319 (1990)
- Rae AM, "The effect of a history of alcohol dependence in adult major depression", J Affect Disord, 70, pp.281~290 (2002)
- Berglund M, "The influence of alcohol drinking and alcohol use disorders on psychiatric disorders and suicidal behavior", Alcohol Clin Exp Res, 22, pp.333S~345S (1998)
- Nellissery M, "Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics", Alcohol Clin Exp Res, 27, pp.1402~1408 (2003)
- Jun KG, "Development of the life stress scale for college students, a control theory approach", Kor J Clin Psychol, 10, pp.137~158 (1991)
- Shin J, "Psychological traits and brief intervention effects on drinking problem in collge students", pp.2000
- Ohayon MM, "Prevalence of major depressive disorder in the general population of South Korea", J Psychiatr Res, 40, pp.30~36 (2006)
- Lee CK, "The nationwide epidemiological study of mental disorders in korea", J Korean Med Sci, 2, pp.19~34 (1987)
- Sakock BJ, "Kaplan & Sadock’s synopsis of psychiatry, 10th ed", pp.390~411 (2000), Lippincott Williams & Wilkins
- Billings AG, "Coping, stress, and social resources among adults with unipolar depression", J Pers Soc Psychol, 46, pp.877~891 (1984)
- Kanner AD, "Comparison of two modes of stress measurement: daily hassles and uplifts versus major life events", J Behav Med, 4, pp.1~39 (1981)
- 이철순, "한국인 집단에서 알코올 의존과 세로토닌 수송체 유전자 다형성의 연관성", 생물치료정신의학, 13(2), pp.232~238 (2007), 대한생물치료정신의학회
- Lim SW, "Serotonin transporter gene polymorphism and major depression", J Korean Neuropsychiatr Assoc, 39, pp.199~207 (2000)
- Risch N, "Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis", JAMA, 301, pp.2462~2471 (2009)
- Wilhelm K, "Life events, first depression onset and the serotonin transporter gene", Br J Psychiatry, 188, pp.210~215 (2006)
- Zalsman G, "Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression", Am J Psychiatry, 163, pp.1588~1593 (2006)
- Murphy DL, "Genetic perspectives on the serotonin transporter", Brain Res Bull, 56, pp.487~494 (2001)
- Bennett P, "The Wellcome trust UK-Irish bipolar affective disorder siblingpair genome screen: first stage report", Mol Psychiatry, 7, pp.189~200 (2002)
- Hariri AR, "Serotonin transporter genetic variation and the response of the human amygdala", Science, 297, pp.400~403 (2002)