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한국인 집단에서 알코올 의존과 Tryptophan Hydroxylase A218C 유전자 다형성의 연관성

Association between Alcohol Dependence and the Genetic Polymorphism of the Tryptophan Hydroxylase A218C in Korean Population

박철수|김봉조|손진욱|이철순|이환철|구준|한규희|윤혁진
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2006.06|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제12권 제1호|pp. 76-82

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참고문헌

주제분류정신과학

초록

목적: 알코올 의존은 환경적 요인과 생물학적 요인이 복합되어 발생하는 것으로 널리 알려진 질환으로 최근 가족, 쌍생아 및 양자 연구에서 유전적 요인의 중요성이 시사되고 있다. 본 연구는 알코올 의존의 유전적 요인을 찾기 위해 세로토닌 합성 조절 효소인 tryptophan hydroxylase (TPH) A218C 유전자 다형성 빈도를 정상 대조군과 비교하였으며 알코올 의존 환자에서 TPH A218C의 유전자 다형성과 임상적 변인과의 관련성을 알아보고자 하였다.

Abstract

Objective: Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. In this study, we explored the genetic causes of alcohol dependence by comparing the frequency of the tryptophan hydroxylase (TPH) A218C between patients with alcohol dependence and control subjects in Korean population. We also explored the association between TPH A218C polymorphism and clinical characteristics in patients with alcohol dependence.Method: The genotype and allele frequencies of TPH were investigated in 182 normal control and 162 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) criteria for alcohol dependence. We conducted clinical assessments using Alcohol Dependence Scale (ADS), Beck Depression Inventory, Beck Anxiety Inventory, and Obsessive-Compulsive Drinking Scale. Results: The frequency of AA genotype and A allele is higher in patients with alcohol dependence than in normal control. Alcoholics with the TPH CC or AC genotypes had a later age of disease onset (mean age of onset, 33.6 and 30.5 years, respectively) than those with the AA genotype (mean age of onset, 25.8 years; p< .001). Also we found the TPH AA genotype has a higher score on the Korean version of the ADS than those with CC genotypes (p= .001). Conclusion: Our results suggest that TPH polymorphism may be a crucial factor in the development of alcohol dependence and may explain, in part, the biological basis for these typologies.

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