본문 바로가기
KERD
논문KCI 등재

티타늄 임플란트의 항균코팅 동향

An Overview of Research Trends in Antibacterial Coatings on Titanium Implants

김경남|김우현
대한치과의사협회 (korea dental association)|2010.02|대한치과의사협회지 (Journal of Korean Dental Association)|제48권 제2호|pp. 113-118|DOI 10.22974/jkda.2010.48.2.004

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

InfectionTitaniumImplantDrug deliveryAntibacterial coating
주제분류치의학

초록

티타늄 및 티타늄 합금은 우수한 기계적 성질과 생체적합성, 그리고 골유착(osseointegration) 특성으로 인해 치과와 정형외과의 임플란트 재료로서 성공적으로 이용되고 있으며, 임상적으로도 높은 성공률을 나타내고 있다1). 또한 최근에는 골유착을 촉진시키기 위하여 임플란트 표면에 조골세포(osteoblast)의초기 부착을 증진시키기 위한 다양한 표면처리들이 연구, 개발되고 있다2~4). 하지만 임플란트 사용이 증가함에 따라 이에 따른 감염으로 인한 임플란트 실패 역시 증가하고 있으며, 이러한 실패를 줄이기 위하여 현재 임플란트의 항균능력을 증진시키려는 연구들이 진행되고 있다5~7). 따라서 이번 연구에서는 티타늄 임플란트의 항균코팅의 동향에 대해서 살펴보고 각각의 특징들을 설명하고자 한다.

Abstract

Titanium and titanium alloys are the most common materials used for dental and biomedical implants, owing to their biocompatibility and favourable mechanical properties. However infection of the region surrounding a dental implant by pathogenic microorganisms is a significant factor in implant failure. Prevention and control of microbial colonization of implant surfaces is considerable interest to the biomedical community. One important strategy is to render the implant surface antibacterial by impeding the formation of biofilm. A number of approaches have been proposed for this purpose. Therefore, we reviewed the researches of antibacterial coatings on titanium implants in this articles.

참고문헌 (36)

  1. Ratner D, "An Introduction to Materials in Medicine: Biomaterials Science. 2nd Edition" (2004), Elsevier Academic Press
  2. Le Guéhennec L, "Surface treatments of titanium dental implants for rapid osseointegration", Dent Mater, 23, pp.844~854 (2007)
  3. Daugaard H, "The effect on bone growth enhancement of implant coatings with hydroxyapatite and collagen deposited electrochemically and by plasma spray", J Biomed Matter Res A, 92, pp.913~921 (2009)
  4. Kim TI, "Biomimetic approach to dental implants", Curr Pharm Des, 14(22), pp.2201~2211 (2008)
  5. Darouiche RO, "Treatment of infections associated with surgical implants", N Engl J Med, 350, pp.1422~1429 (2004)
  6. Harris LG, "Staphylococci and implant surfaces: A review", Injury, 37(2), pp.3~14 (2006)
  7. Stigter M, "Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy", J Control Release, 99, pp.127~137 (2004)
  8. Zhao L, "Antibacterial coatings on titanium implants", J Biomed Matter Res A, 91, pp.470~480 (2009)
  9. Duran LW, "Preventing medical device related infections", Med Device Technol, 11, pp.14~17 (2000)
  10. Radin S, "Calcium phosphate ceramic coatings as carriers ofvancomycin", Biomaterials, 21, pp.243~249 (1997)
  11. Aebli N, "Degradation of hydroxyapatite coating on a well-functioning femoral component", J Bone Joint Surg Br, 85(4), pp.499~503 (2003)
  12. Price JS, "Controlled release of antibiotics from coated orthopedic implants", J Biomed Mater Res, 30, pp.281~286 (1996)
  13. Gollwitzer H, "Antibacterial poly(D,Llactic acid) coating of medical implants using a biodegradable drug delivery technology", J Antimicrob Chemother, 51, pp.585~591 (2003)
  14. Harris LG, "Bacteria and cell cytocompatibility studies on coated medical grade titanium surfaces", J Biomed Mater Res, 78, pp.50~58 (2006)
  15. Edupuganti OP, "Covalent bonding of vancomycin to Ti6Al4V alloy pins provides longterm inhibition of Staphylococcus aureus colonization", Bioorg Med Chem Lett, 17, pp.2692~2696 (2007)
  16. Antoci V Jr, "The inhibition of Staphylococcus epidermidis biofilms formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection", Biomaterials, 29, pp.4684~4690 (2008)
  17. Wolf J, "Drug release of coated dental implant neck region to improve tissue integration", Biomed Tech, 54(4), pp.219~217 (2009)
  18. Melaiye AYW, "Silver and its application as an antimicrobial agent", Expert Opin Ther Pat, 15, pp.125~130 (2005)
  19. Percival SL, "Bacterial resistance to silver in wound care", J Hos Infect, 60, pp.1~7 (2005)
  20. Bosetti M, "Silver coated materials for external fixation devices: In vitro biocompatibility and genotoxicity", Biomaterials, 23, pp.887~892 (2002)
  21. Hardes J, "Lack of toxicological side-effects in silver-coated megaprotheses in humans", Biomaterials, 28, pp.2869~2875 (2007)
  22. Zhang W, "Ag and Ag", N plasma modification of polyethylene for the enhancement of antibacterial properties and cell growth, Acta Biomater, pp.2008, 4[DOI]
  23. Ewald A, "Antimicrobial titanium", siver PVD coatings on titanium, 2006, pp.5, 22~
  24. Chen W, "In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating", Biomaterials, 27, pp.5512~5517 (2006)
  25. Kakoli D, "Surface coating for improvement of bone cell materials and antimicrobial activities of Ti implant", J Biomed Mater Res, 87, pp.455~460 (2008)
  26. Nablo BJ, "In vitro cytotoxicity of nitric oxide-releasing sol-gel derived materials", Biomaterials, 26, pp.4405~4415 (2005)
  27. MacMicking J, "Nitric oxide and macrophage function", Annu Rev Immunol, 15, pp.323~350 (1997)
  28. Nablo BJ, "Nitric oxide-releasing sol-gel as antibacterial coatings for orthopedic implants", Biomaterials, 26, pp.917~924 (2005)
  29. Hetrick EM, "Antibacterial nitric oxide releasing xerogels: Cell viability and parallel plate flow cell adhesion studies", Biomaterials, 28, pp.1948~1956 (2007)
  30. Gallardo-Moreno AM, "In vitro biocompatibility and bacterial adhesion of UV irradiation", Acta Biomater, 5, pp.181~192 (2009)
  31. Legeay G, "New surfaces with hydrophilic", hydrophobic characteristics in relation to (no)bioadhesion, 2006, pp.29, 453~461
  32. Choi JY, "Photocatalystic antibacterial effect of TiO2 films formed on Ti and TiAg exposed to Lactobacillus acidophilus", J Biomed Mater Res, 80, pp.353~359 (2007)
  33. Aita H, "The effect of ultraviolet functionalization of titanium on integration with bone", Biomaterials, 30, pp.1015~1025 (2009)
  34. Del Curto B, "Decreased bacteria adhesion to surface-treated titanium", Int J Artif Organ, 28, pp.718~730 (2005)
  35. Zhang F, "Silk-functionalized titanium surface for enhancing osteoblast functions and reducing bacterial adhesion", Biomaterials, 29, pp.4751~4759 (2008)
  36. Harris LG, "Staphylococcus aureus adhesion to titanium oxide surfaces coated with nonfunctionalized and peptide-functionalized poly(Llysine)- grafted-poly(ethylene glycol) copolymer", Biomaterials, 25, pp.4135~4148 (2004)

관련 논문AI추천

치과용 임플란트 적용을 위한 항균력을 가진 티타늄 표면의 평가강민경, 김경남, 문승균한국치위생과학회 · 치위생과학회지2011 · 제11권 제5호치과용 티타늄 임플란트의 골융합 증진을 위한 체어사이드 친수성 표면처리방법이정환, 이해형, 전수경대한치과의사협회 · 대한치과의사협회지2016 · 제54권 제12호티타늄 임플란트의 골융합 증진을 위한 최신 표면처리 기술송호준대한치과의사협회 · 대한치과의사협회지2010 · 제48권 제2호Antimicrobial surfaces for craniofacial implants: state of the artJoo L. Ong, Laura Gaviria, Lisa Actis, Teja Guda대한구강악안면외과학회 · 대한구강악안면외과학회지2013 · 제39권 제2호Evaluation of antibacterial activity and osteoblast-like cell viability of TiN, ZrN and (Ti1-xZrx)N coating on titanium강인철, 김현승, 박상원, 윤귀덕, 이광민, 임현필, 지민경대한치과보철학회 · The Journal of Advanced of Prosthodontics2015 · 제7권 제2호치과 임플란트 표면의 과거, 현재, 그리고 미래김영택대한치과의사협회 · 대한치과의사협회지2021 · 제59권 제4호

이 간행물의 다른 논문 (6건)

의료전달체계 확립과 전문의 진료 영역 명확화를 위한 의료법 개정 추진 방향이수구pp. 91-94티타늄 임플란트의 골융합 증진을 위한 최신 표면처리 기술송호준pp. 96-105티타늄 임플란트 표면처리에서의 나노테크놀로지오승한pp. 106-112즉시 혹은 조기하중 임프란트에 관한 후향적 연구윤필영, 이승연, 김영균, 이양진, 여인성pp. 119-126치과병의원 안에서 고객만족을 위한 마케팅연구 -치과의사와 직원간의 기대와 만족을 중심으로-김양균, 김용태pp. 127-139
원문 보기