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주요우울증 환자에서 세로토닌 6 (5-HT6) 수용체 C267T 다형성과 citalopram 치료반응에 대한 연구

No association between the 5-HT6 receptor C267T polymorphism and response to citalopram treatment in patient with major depressive disorder

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참고문헌

주제분류정신과학

초록

Abstract

The serotonin 6 (5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 90 patients who completed study. We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with citalopram treatment response. Key WordsMajor depressive disorder, 5-HT6 receptor , C267T polymorphism, citalopram.

참고문헌 (35)

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관련 논문AI추천

한국인 주요우울증 환자에서의 세로토닌 5A 수용체의 유전자 다형성 및 citalopram 치료반응과의 관련성강이헌, 백종우, 심진현, 오정웅, 이민수, 이화영대한생물정신의학회 · 생물정신의학2008 · 제15권 제4호한국인 주요 우울증 환자의 세로토닌 수송체 유전자 다형성과 혈소판 [3H]-세로토닌 흡수양상김도관, 김성환, 김혜란, 서민영, 임신원대한신경정신의학회 · 신경정신의학2003 · 제42권 제1호한국인 우울 장애 환자에서 Brain-Derived Neurotrophic Factor (BDNF)의 유전자 다형성과 항우울제의 장기 치료 반응강이헌, 구재우, 백종우, 이민수, 이화영대한생물정신의학회 · 생물정신의학2006 · 제13권 제3호정신분열병환자에서 만발성 운동장애와 5-HT6 수용체 유전자 다형성(267C/T)과의 관계김동현, 전용호, 한상우대한생물정신의학회 · 생물정신의학2004 · 제11권 제1호Relationship between the Polymorphism of Cytochrome P-450 2D6 and Theclinical Outcomes of Paroxetine in Korean Patients with Depressive DisordersKang Seob Oh, Min Soo Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2003 · 제1권 제1호정신분열병 환자의 비정형 항정신병약물 반응과 세로토닌 2A 및 도파민 D3 수용체 유전자 다형성의 관련연구김병수, 김창윤, 박지홍, 송규영, 주연호, 한오수대한신경정신의학회 · 신경정신의학2002 · 제41권 제3호

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