한국인 우울 장애 환자에서 Brain-Derived Neurotrophic Factor (BDNF)의 유전자 다형성과 항우울제의 장기 치료 반응
Brain-Derived Neurotrophic Factor (BDNF) Genetic Polymorphism and the Long-term Outcome of Antidepressant Treatment in Korean Depressive Patients
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Abstract
Objective : Since some studies have shown that the brain-derived neurotrophic factor (BDNF) has an important role in the pathophysiology of depression, this study investigated the relationship between BDNF genetic polymorphism and the long-term outcome of the antidepressant treatment.Method : One hundred and eight patients with major depressive disorder were evaluated for the long-term outcome (up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression (CGI) Scale. The genotypes of BDNF 196A/G polymorphism in the patients were determined using Restriction Fragment Length Polymorphism (RFLP).Result: The genotypes of 128 patients were investigated and 95 patients of those haves been evaluated for 3 years. No significant differences were noted comparing three-genotype groups for CGI scales at baseline, 4 weeks, 8 weeks, 1 year, 2 years and 3 years.Conclusion : This result shows that BDNF polymorphism investigated in this study was not associated with in the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed.
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