방사선 유도 돌연변이체 블랙베리로 제조한발효음료의 간 손상 회복 효과
Effect of Fermented Blackberry Drinks Formed from Radiation-induced Mutant on Liver Repair Capacity in Rats
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초록
This study was conducted to investigate the effect of fermented blackberry drinks (BD)on carbon tetrachloride (CCl4)-induced liver injury in rats. Male Sprague-Dawley rats were randomlydivided into four groups with 6 rats per group: control, CCl4, CCl4 plus BD 3 ml kg-1, andCCl4 plus BD 6 ml kg-1. We found that the levels of serum aspartate aminotransferase (AST) andalanine aminotransferase (ALT) were significantly increased and the activity of antioxidant enzymeglutathione peroxidase (GPx) in the liver was decreased in rats treated with CCl4 alone when comparedwith the control group. However, the administration of BD attenuated the levels of serumAST and ALT in CCl4-treated rats. Moreover, the administration of BD significantly increasedthe activity of GPx in CCl4-treated rat livers. Taken together, these results suggest that BD couldprotect the liver from CCl4-induced hepatic damage.
Abstract
This study was conducted to investigate the effect of fermented blackberry drinks (BD)on carbon tetrachloride (CCl4)-induced liver injury in rats. Male Sprague-Dawley rats were randomlydivided into four groups with 6 rats per group: control, CCl4, CCl4 plus BD 3 ml kg-1, andCCl4 plus BD 6 ml kg-1. We found that the levels of serum aspartate aminotransferase (AST) andalanine aminotransferase (ALT) were significantly increased and the activity of antioxidant enzymeglutathione peroxidase (GPx) in the liver was decreased in rats treated with CCl4 alone when comparedwith the control group. However, the administration of BD attenuated the levels of serumAST and ALT in CCl4-treated rats. Moreover, the administration of BD significantly increasedthe activity of GPx in CCl4-treated rat livers. Taken together, these results suggest that BD couldprotect the liver from CCl4-induced hepatic damage.
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