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Induction Patterns of Suppressor of Cytokine Signaling (SOCS) by Immune Elicitors in Anopheles sinensis

이용석|이인희|김익수|조용훈|한만덕|방인석|김흥철|한연수|노미영|서숙재|전재선|신이현
한국잠사학회 (Korean Society Of Sericultural Science)|2006.06|International Journal of Industrial Entomology and Biomaterials|제12권 제2호|pp. 57-61

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Abstract

Suppressor of cytokine signaling (SOCS) is known to be as a negative feedback regulator in Janus kinase signal transducer and activator of transcription signaling. Highly conserved SOCS box domain was cloned from a Korean malaria vector, Anopheles sinensis. Sequence analysis indicates that it has identity to Anopheles gambiae (96%), Aedes aegypti (94%), Drosophila melanogaster (78%), Mus musculus (72%) and Homo sapiens (72%), respectively. Tissue specificity RT-PCR demonstrated that the expression level of AsSOCS transcript was high at abdomen, midgut, and ovary, whereas developmental expression patterns showed that the level of AsSOCS was high at egg, early pupae, and adult female. On the other hand, RT-PCR analysis after bacterial challenge showed that SOCS mRNA was strongly induced in larvae. In addition, it was also induced by various immune elicitors such as lipoteicoic acid, CpG-DNA, and laminarin. It seems that AsSOCS, repressor of JAK-STAT pathway, is highly conserved in mosquito, and may play an important role in mosquito innate immune response.

참고문헌 (16)

  1. "The role of suppressors of cytokine signaling proteins in regulation of the immune response", 22, pp.503~529 (2004)
  2. "Anopheles gambiae Ag-STAT, a new insect member of the STAT family is activated in response to bacterial infection", 18, pp.959~967 (1999)
  3. "Mosquito immune responses and malaria transmission: lessons from insect model systems and implications for vertebrate innate immunity and vaccine development", 30, pp.429~442 (2000)
  4. "SOCS36E, a novel Drosophila SOCS protein, suppresses JAK", STAT and EGF-R signaling in the imaginal wing disc, 2002, pp.21, 4812~4821
  5. "SOCS: role in inflammation, allergy and homeostasis", 25, pp.434~440 (2004)
  6. "Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei the time bomb theory of ookinete invasion of mosquitoes", 19, pp.6030~6040 (2000)
  7. "Implications of time bomb model of ookinete invasion of midgut cells", 32, pp.1311~1316 (2002)
  8. "The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS", 12, pp.3872~3881 (1998)
  9. "Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK", STAT pathway, 2002, pp.117, 343~346
  10. "Characterization of two mosquito STATs Differential regulation of tyrosine phosphorylation and DNA binding activity by lipopolysaccharide treatment and by Japanese encephalitis virus infection", 279, pp.3308~3317 (2004)
  11. "The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide", 95, pp.5700~5705 (1998)
  12. "Two Drosophila suppressors of cytokine signaling", 5, pp.38~52 (2004)
  13. "Study on laboratory colonization and mass-rearing of Anopheles sinensis", 33, pp.267~271 (2003)
  14. "The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools", 25, pp.4876~82 (1997)
  15. "Identification of a stat gene that functions in Drosophila development", 84, pp.421~430 (1996)
  16. "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation", 96, pp.2071~2076 (1999)

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