두피 지루피부염에서 Home-use Light Emitting Diode (LED)의 치료효과: 예비연구
Effectiveness of Home-use Light Emitting Diode Device for Seborrheic Dermatitis of the Scalp: a Preliminary Study
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Background: Seborrheic dermatitis (SD) is a chronic, relapsing inflammatory disease, mainly affectingthe scalp and face. The pathogenesis of SD has been not fully understood yet, but may be related to theskin colonization of Malassezia species, lipophilic yeasts. Phototherapy with light emitting diode (LED)device has been become a new therapeutic modality for some skin diseases such as acne. Objective: To evaluate effectiveness and safety of phototherapy with home-use LED in the treatmentof patients with SD of the scalp. Methods: Eight patients with mild-to-moderate SD of the scalp participated. The patients used ahome-use LED device combined 395 nm blue light with 660 nm red light for 6~7 min twice daily for 8weeks. Patients' assessments were made by clinical findings including erythema (0~15), scales (0~15),itching (0~10), and lesional extent (0~15). And clinical photographs were taken at 0, 2, 4 and 8 weeks,respectively. Results: At 8 weeks after LED treatment, erythema (7.75 to 5.13, p=0.018), scales (7.38 to 4.13,p=0.017), itching (6 to 3, p=0.011) and lesional extent (8.25 to 5.25, p=0.017) were significantlydecreased, respectively. Satisfactory scores were also relatively high (mean 8.13 of 10). No severeadverse reaction was reported, excepting hair dryness (n=1) and brief stinging sense (n=1). Conclusion: Home-use LED was effective and safe in the treatment of SD of the scalp. These resultssuggest the LED device might be an adjuvant therapeutic tool in the treatment of Malassezia speciesassociated diseases such as dandruff and SD. Further long-term and large-scale studies are required toassess the efficacy and safety of home-use LED.
Abstract
Background: Seborrheic dermatitis (SD) is a chronic, relapsing inflammatory disease, mainly affectingthe scalp and face. The pathogenesis of SD has been not fully understood yet, but may be related to theskin colonization of Malassezia species, lipophilic yeasts. Phototherapy with light emitting diode (LED)device has been become a new therapeutic modality for some skin diseases such as acne. Objective: To evaluate effectiveness and safety of phototherapy with home-use LED in the treatmentof patients with SD of the scalp. Methods: Eight patients with mild-to-moderate SD of the scalp participated. The patients used ahome-use LED device combined 395 nm blue light with 660 nm red light for 6~7 min twice daily for 8weeks. Patients' assessments were made by clinical findings including erythema (0~15), scales (0~15),itching (0~10), and lesional extent (0~15). And clinical photographs were taken at 0, 2, 4 and 8 weeks,respectively. Results: At 8 weeks after LED treatment, erythema (7.75 to 5.13, p=0.018), scales (7.38 to 4.13,p=0.017), itching (6 to 3, p=0.011) and lesional extent (8.25 to 5.25, p=0.017) were significantlydecreased, respectively. Satisfactory scores were also relatively high (mean 8.13 of 10). No severeadverse reaction was reported, excepting hair dryness (n=1) and brief stinging sense (n=1). Conclusion: Home-use LED was effective and safe in the treatment of SD of the scalp. These resultssuggest the LED device might be an adjuvant therapeutic tool in the treatment of Malassezia speciesassociated diseases such as dandruff and SD. Further long-term and large-scale studies are required toassess the efficacy and safety of home-use LED.
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