Normal data on axonal excitability in Koreans
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Background: Automated nerve excitability testing is used to assess various peripheral neuropathies and motor neuron diseases. Comparing these excitability parameters with normal data provides information regarding the axonal excitability properties and ion biophysics in diseased axons. This study measured and compared normal values of axonal excitability parameters in both the distal motor and sensory axons of normal Koreans. Methods: The axonal excitability properties of 50 distal median motor axons and 30 distal median sensory axons were measured. An automated nerve excitability test was performed using the QTRACW threshold-tracking software (Institute of Neurology, University College London, London, UK) with the TRONDF multiple excitability recording protocol. Each parameter of stimulus–response curves, threshold electrotonus, current–voltage relationship, and recovery cycle was measured and calculated. Results: Our Korean normal data on axonal excitability showed ranges of values and characteristics similar to previous reports from other countries. We also reaffirmed that there exist characteristic differences in excitability properties between motor and sensory axons: compared to motor axons, sensory axons showed an increased strength–duration time constant, more prominent changes in threshold to hyperpolarizing threshold electrotonus (TE) and less prominent changes in threshold to depolarizing TE, and more prominent refractoriness and less prominent subexcitability and superexcitability. Conclusions: We report normal data on axonal excitability in Koreans. These data can be used to compare various pathological conditions in peripheral nerve axons such as peripheral neuropathies and motor neuron disease.
Abstract
Background: Automated nerve excitability testing is used to assess various peripheral neuropathies and motor neuron diseases. Comparing these excitability parameters with normal data provides information regarding the axonal excitability properties and ion biophysics in diseased axons. This study measured and compared normal values of axonal excitability parameters in both the distal motor and sensory axons of normal Koreans. Methods: The axonal excitability properties of 50 distal median motor axons and 30 distal median sensory axons were measured. An automated nerve excitability test was performed using the QTRACW threshold-tracking software (Institute of Neurology, University College London, London, UK) with the TRONDF multiple excitability recording protocol. Each parameter of stimulus–response curves, threshold electrotonus, current–voltage relationship, and recovery cycle was measured and calculated. Results: Our Korean normal data on axonal excitability showed ranges of values and characteristics similar to previous reports from other countries. We also reaffirmed that there exist characteristic differences in excitability properties between motor and sensory axons: compared to motor axons, sensory axons showed an increased strength–duration time constant, more prominent changes in threshold to hyperpolarizing threshold electrotonus (TE) and less prominent changes in threshold to depolarizing TE, and more prominent refractoriness and less prominent subexcitability and superexcitability. Conclusions: We report normal data on axonal excitability in Koreans. These data can be used to compare various pathological conditions in peripheral nerve axons such as peripheral neuropathies and motor neuron disease.
참고문헌 (22)
- Bae JS, "Subclinical diabetic neuropathy with normal conventional electrophysiological study", J Neurol, 254, pp.53~59 (2007)
- Kuwabara S, "Axonal ionic pathophysiology in human peripheral neuropathy and motor neuron disease", Curr Neurovasc Res, 1, pp.373~379 (2004)
- Nodera H, "Nerve excitability testing and its clinical application to neuromuscular diseases", Clin Neurophysiol, 117, pp.1902~1916 (2006)
- Kiernan MC, "Multiple measures of axonal excitability : a new approach in clinical testing", Muscle Nerve, 23, pp.399~409 (2000)
- Burke D, "Excitability of human axons", Clin Neurophysiol, 112, pp.1575~1585 (2001)
- Jankelowitz SK, "Changes in measures of motor axon excitability with age", Clin Neurophysiol, 118, pp.1397~1404 (2007)
- Bae JS, "Effects of age on excitability properties in human motor axons", Clin Neurophysiol, 119, pp.2282~2286 (2008)
- Paeing SH, "Relative sparing of the second lumbrical muscle in carpal tunnel syndrome is not associated with regional differences in axonal membrane potential", Clin Neurophysiol, 127, pp.905~910 (2016)
- Bae JS, "Altered nerve excitability in subclinical", early diabetic neuropathy: evidence for early neurovascular process in diabetes mellitus?, 2011, pp.91, 183~189
- Mogyoros I, "Strength-duration properties of human peripheral nerve", Brain, 119(Pt 2), pp.439~447 (1996)
- Z'Graggen WJ, "Nerve excitability changes in critical illness polyneuropathy", Brain, 129(Pt 9), pp.2461~2470 (2006)
- Murray JE, "A comparison of the excitability of motor axons innervating the APB and ADM muscles", Clin Neurophysiol, 122, pp.2290~2293 (2011)
- Jankelowitz SK, "Axonal excitability in the forearm : normal data and differences along the median nerve", Clin Neurophysiol, 120, pp.167~173 (2009)
- Kiernan MC, "Effects of temperature on the excitability properties of human motor axons", Brain, 124(Pt 4), pp.816~825 (2001)
- Mogyoros I, "Excitability changes in human sensory and motor axons during hyperventilation and ischaemia", Brain, 120(Pt 2), pp.317~325 (1997)
- Krishnan AV, "Altered motor nerve excitability in end-stage kidney disease", Brain, 128(Pt 9), pp.2164~2174 (2005)
- Bostock H, "Threshold tracking techniques in the study of human peripheral nerve", Muscle Nerve, 21, pp.137~158 (1998)
- Kiernan MC, "Clinical evaluation of excitability measures in sensory nerve", Muscle Nerve, 24, pp.883~892 (2001)
- Kuwabara S, "Physiological differences in excitability among human axons", Clin Neurophysiol, 120, pp.1~2 (2009)
- Lin CS, "Accommodation to depolarizing and hyperpolarizing currents in cutaneous afferents of the human median and sural nerves", J Physiol, 2, pp.483~492 (2000)
- Bae JS, "Automated nerve excitability test by utilizing threshold tracking technique", Korean J Clin Neurophysiol, 16(Suppl 1), pp.82~86 (2014)
- Krishnan AV, "Nerve excitability properties in lower-limb motor axons : evidence for a length-dependent gradient", Muscle Nerve, 29, pp.645~655 (2004)