수면과 알츠하이머 치매의 관계
Relationship Between Sleep and Alzheimer’s Dementia
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초록
현재까지 수면과 인지 기능에 관련된 많은 연구들이 발표되고 있다. 수면의 질이 나쁠수록 인지기능에 나쁜 영향을 미친다는 연구 결과는 많다. 그러나 이에 대한 정확한 기전 은 아직은 일치된 견해가 없는 실정이다. 수면은 뇌의 기능을 복원시켜주는 중요한 기능을 하고 있으며, 수면의 초기에 주로 나타나는 서파 수면과 후기에 주로 나타나는 REM 수 면이 각각 서술 기억과 비서술기억의 강화에 중요한 역할을 하는 것과 동시에 순차 가설에 의하면 상호보완적으로 기억을 강화시켜주는데 기능을 하고 있다. 또한 적절하지 못한 수면이 아밀로이드 베타와 타우 단백질의 축적을 증가시키는 것으로 나타났다. 이에 따라 대표적인 노인성 질환인 치 매를 비롯한 인지기능 장애를 예방하는 데에 있어 적절히 수면을 취하는 것이 중요하다 할 수 있으며, 향후 이에 관한 대규모의 연구가 절실히 필요하다.
Abstract
Sleep is associated with Alzheimer’s dementia. Many previous researches have shown that inadequate sleep is one of the risk factors that predict Alzheimer’s dementia. The causal mechanism of this association is not clear. Slow wave sleep and REM sleep are critical stages in memory consolidation, and by sequential hypothesis both stages are important. Deposition of amyloid beta and tau, the main pathology of Alzheimer’s dementia, are also associated with sleep. This review provides the association of sleep and Alzheimer’s dementia, and future research is necessary to examine the specific mechanism of this association between sleep and Alzheimer’s dementia, which may lead to an early intervention in sleep.
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