Effects of Paraprobiotic Limosilactobacillus fermentum HDB1098 on Hangover Improvement in Humans: A Randomized Double-Blind Placebo-Controlled Crossover Clinical Trial
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Hangover refers to various mental and physical side effects following alcohol consumption. This study investigated the efficacy of paraprobiotic Limosilactobacillus fermentum HDB1098 (MB-LFH1098, Pharmavio ALC) on improving hangover symptoms and was designed as a randomized double-blind crossover placebo-controlled clinical trial conducted with 28 participants. Participants consumed 42.8% whiskey with equivalent to 90 g of alcohol and serum alcohol and acetaldehyde levels were measured at 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption. Both serum alcohol (p < 0.01) and acetaldehyde (p < 0.05) levels over time, AUC, Cmax, and Tmax for serum acetaldehyde level were significantly lower (p < 0.05) in the HDB1098 group compared to the placebo group. Furthermore, the total scores of AHS and AHSS were significantly lower (p < 0.0001) in the HDB1098 group than the placebo group, with improvement of several indicators in each questionnaire. These findings indicate that HDB1098 administration can effectively contribute to relief of hangover symptoms.
Abstract
Hangover refers to various mental and physical side effects following alcohol consumption. This study investigated the efficacy of paraprobiotic Limosilactobacillus fermentum HDB1098 (MB-LFH1098, Pharmavio ALC) on improving hangover symptoms and was designed as a randomized double-blind crossover placebo-controlled clinical trial conducted with 28 participants. Participants consumed 42.8% whiskey with equivalent to 90 g of alcohol and serum alcohol and acetaldehyde levels were measured at 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption. Both serum alcohol (p < 0.01) and acetaldehyde (p < 0.05) levels over time, AUC, Cmax, and Tmax for serum acetaldehyde level were significantly lower (p < 0.05) in the HDB1098 group compared to the placebo group. Furthermore, the total scores of AHS and AHSS were significantly lower (p < 0.0001) in the HDB1098 group than the placebo group, with improvement of several indicators in each questionnaire. These findings indicate that HDB1098 administration can effectively contribute to relief of hangover symptoms.