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아토피피부염 환아에서 요중 Leukotriene E4 와 혈청 Eosionphil Cationic Protein과 임상적 활동성과의 상관관계

Correlation between the Level of Urinary Leukotriene E4 and Seurm Eosinophil Cationic Protein and Clinical Severity of Atopic Dermatitis in Children

오재원|김정미|신수아|이하백
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)|2004.12|천식 및 알레르기|제24권 제4호|pp. 409-414

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주제분류임상병리학

초록

Abstract

Background: Atopic dermatitis is a chronic inflammatory relapsing skin disorder. It has been shown that urinary LTE4 and serum ECP level are elevated and correlated with disease activity. Objective: We performed this study to measure the urinary LTE4 and serum ECP level in atopic dermatitis, and to evaluate the correlation between their levels and the clinical severity of atopic dermatitis by using SCORAD index. Method: We recruited 65 children with atopic dermatitis and 15 children with healthy control. We classified the atopic dermatitis patients by using SCORAD and excluded any other allergic or infectious diseases. In all children, serum ECP and urine LTE4 were measured. Result: Serum ECP levels were not significantly different between atopic dermatitis (39.1±34.9μg/L) and healthy children (13.1±7.7μg/L), and were not significantly correlated with SCORAD index in atopic dermatitis children. (R2=0.097, P＜0.05) Atopic dermatitis children (212.3±135.6 mmol/mol creatinine) had significantly higher urine LTE4 levels than healthy controls (57.9±31.94 mmol/mol creatinine). Urine LTE4 levels were significantly correlated with SCORAD index (R2=0.664, P＜0.05). Conclusion: Urine LTE4 level was significantly correlated with SCORAD index in children with atopic dermatitis and may be a useful marker for disease activity in atopic dermatitis.

참고문헌 (23)

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관련 논문AI추천

소아 아토피피부염에서 중증도 및 흡입 항원 감작과 요중 leukotriene E4농도의 연관성김민지, 김봉성, 박기영, 신순정, 오미영, 정민희, 진현승, 한명기대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2012 · 제22권 제3호소아 아토피피부염에서 아토피성과 비아토피성의 중증도와 검사소견의 비교신정은, 양현종, 전유훈, 편복양대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2008 · 제18권 제3호천명이 있는 영유아에서 뇨중 Leukotriene E4와 비인두액 Eosinophil Cationic Protein에 관한 연구구본석, 권수정, 오재원, 이하백대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2004 · 제14권 제1호경증 천식 환아에서 아토피피부염의 동반이 하기도 호산구 염증에 미치는 영향강임주, 김영진, 송도영, 이세규, 이지현대한천식알레르기학회 · 천식 및 알레르기2006 · 제26권 제3호SCORing atopic dermatitis index로 평가한 아토피피부염의 중증도와 혈액 검사와의 연관성김성원, 박근화, 박종하, 성명순, 황윤하대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제1호소아 알레르기질환에서 감작 패턴에 따른 혈중 호산구와 총 IgE의 비교김현희, 김환수, 양은애, 이혜진, 전윤홍대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2024 · 제12권 제1호

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