한우에서 ANK1 유전자 Promoter 지역 내 단일염기변이(SNP)와 경제형질간 연관성 분석
SNPs in Promoter Region of Hanwoo ANK1 Gene with Their Effects on Economic Traits in Hanwoo
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The ANK1 (Ankyrin-1) gene, located on the bovine chromosome 27, encodes a structural protein which forms an important component of the cytoskeleton. Ankyrin belongs to a protein family that links membrane proteins to the underlying spectrin-actin cytoskeleton. Many studies on gene expression regulation have revealed that RNA polymerase binds to the ANK1 gene promoter region. The purpose of the present study was to investigate the relationship between the SNP of the ANK1 promoter region and economic traits in Hanwoo cattle. A total of seven SNPs (C-944T, C-733T, C-687G, A-672G, C-307T, A-104G, C-24T), found in 119 animals, were correlated to economic traits. One of these SNPs, A-104G, was reported for the first time in the present study. Three newly discovered haplotypes were not associated with economic traits. Significant (p<0.05) relationships were found between C-944T and carcass weight, backfat thickeness, loin muscle area and between C-733T, A-672G and intramuscular fat. These results suggest that the SNPs of ANK1 gene may be useful molecular markers for selection of meat yield and quality traits in Hanwoo
Abstract
The ANK1 (Ankyrin-1) gene, located on the bovine chromosome 27, encodes a structural protein which forms an important component of the cytoskeleton. Ankyrin belongs to a protein family that links membrane proteins to the underlying spectrin-actin cytoskeleton. Many studies on gene expression regulation have revealed that RNA polymerase binds to the ANK1 gene promoter region. The purpose of the present study was to investigate the relationship between the SNP of the ANK1 promoter region and economic traits in Hanwoo cattle. A total of seven SNPs (C-944T, C-733T, C-687G, A-672G, C-307T, A-104G, C-24T), found in 119 animals, were correlated to economic traits. One of these SNPs, A-104G, was reported for the first time in the present study. Three newly discovered haplotypes were not associated with economic traits. Significant (p<0.05) relationships were found between C-944T and carcass weight, backfat thickeness, loin muscle area and between C-733T, A-672G and intramuscular fat. These results suggest that the SNPs of ANK1 gene may be useful molecular markers for selection of meat yield and quality traits in Hanwoo
참고문헌 (21)
- Aslan, O., "Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intramuscular fat content", BMC Genetics, 11, pp.111~ (2010)
- Aslan, O., "Association between promoter polymorphisms in a key cytoskeletal gene(Ankyrin 1)and intramuscular fat and water-holding capacity in porcine muscle", Mol. Biol. Rep, 39, pp.3903~3914 (2012)
- Bennett, V., "Spectrin and ankyrin-based pathways : metazoan inventions for integrating cells into tissues", Physiol. Rev., 81(3), pp.1353~1392 (2001)
- 최창본, "한우, 앵거스 및 화우 교잡종의 등심내 콜레스테롤 함량 및 지방산 조성 비교", 한국동물자원과학회지, 50(4), pp.519~526 (2008), 한국동물자원과학회
- Chorley, B. N., "Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions : Current and developing technologies", Mutat. Res, 659(1-2), pp.147~157 (2008)
- Damon, M., "Associations between muscle gene expression pattern and technological and sensory meat traits highlight new biomarkers for pork quality assessment", Meat Science, 95(3), pp.744~754 (2013)
- Hamill, R. M., "Functional analysis of muscle gene expression profiles associated with tendernessand intramuscular fat content in pork", Meat Science, 92(4), pp.440~450 (2012)
- 김범수, "한우 Exostosin-1 유전자의 SNP 탐색 및 경제형질 관련성 분석", 한국동물자원과학회지, 53(1), pp.7~13 (2011), 한국동물자원과학회
- 이승환, "한우 FASN 유전자변이와 한우 지방형질 및 지방산조성과의 연관성 분석", Korean Journal of Agricultural Science, 38(2), pp.257~262 (2011), 농업과학연구소
- 이승환, "한우 지방산결합단백질 4(FABP4) 유전자 조절영역내 단일염기변이(SNP) 와 도체형질간 연관성 분석", Korean Journal of Agricultural Science, 38(4), pp.673~680 (2011), 농업과학연구소
- Taeheon Lee, "Genome-wide Association Study of Integrated Meat Quality-related Traits of the Duroc Pig Breed", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 27(3), pp.303~309 (2014), 아세아·태평양축산학회[DOI]
- Levine, M., "Transcription regulation and animal diversity", Nature, 424, pp.147~151 (2003)
- McClure, M. C., "A genome scan for quantitative trait loci influencing carcass, post-natal growth and reproductive traits in commercial Angus cattle", Anim. Genet, 41, pp.597~607 (2010)
- 오재돈, "한우의 ACADS 유전자내의 SNP 탐색 및 경제형질과의 연관성 분석", Korean Journal of Agricultural Science, 39(2), pp.219~226 (2012), 농업과학연구소[DOI]
- Park, B. S., "comparison of fatty acid composition among imported beef, Holetin steer beef and Hanwoo beef", Korea Food Research Institute, 36(1), pp.69~75 (1994)
- Planas, J., "Gene promoter evolution targets the center of the human protein interaction network", PLoS One, 5, pp.e11476~ (2010)
- Rubtsov, A. M., "Ankyrins", FEBS Letters, 482, pp.1~5 (2000)
- Taylor, R. G., "Effects of postmortem storage on the ultrastructure of the endomysium and myofibrils in normal and callipyge longissimus", J. Anim. Sci, 76, pp.2811~2817 (1998)
- Van Deveire, K. N., "Variants of the vnkyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults", Journal of Strength and Conditioning Research, 26(7), pp.1740~1748 (2012)
- Wang, Y. H., "Transcriptional profiling of skeletal muscle tissue from two breeds of cattle", Mammalian Genome, 16, pp.201~210 (2005)
- Wimmers, K., "Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition", Anim. Genet, 38, pp.474~484 (2007)