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Metallo-β-lactamase 생성 그람음성 간균

Metallo-β-lactamase Producing Gram-negative Bacilli

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참고문헌

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초록

여러 항균제에 동시에 내성을 보이는 세균이 원내외에 증가하고 있는 현실에서 carbapenem 제제는 임상적으로 매우 중 요하다고 할 수 있다. MBL은 β-lactamase 중 carbapenem 제제를 분해할 수 있는 중요한 효소로서 매우 다양한 분포와 구조를 보인다. 따라서 MBL 생성세균에 대한 연구는 지대한 관심을 받고 있다. 병원감염관리 혹은 환자 치료를 위하여 MBL의 성상, 전파 및 생성 세균에 대한 연구가 계속적으로 요구된다고 판단된다

Abstract

Among gram-negative bacteria, rate of antibiotic resistance has been increasing. As a result, carbapenem is now considered as a last resort of therapeutic regimens for gram-negative bacterial infections. The choice of antibiotics has been impeded by the spread of organisms producing metallo-β-lactamases (MBL), which can confer resistance to nearly all β-lactams. MBLs have extremely diverse structures and are carried by various organisms including human pathogens. This review will focus on the classification and current status of MBL reported in Korea.

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